Differential sensitisation to central cardiovascular effects of angiotensin II in rats with a myocardial infarct: relevance to stress and interaction with vasopressin

The purpose of the present study was to elucidate if rats with myocardial infarction manifest altered responsiveness to central cardiovascular effects of low doses of angiotensin II (ANG II), and if ANG II and vasopressin (VP) cooperate in the central regulation of cardiovascular functions at rest and during stress. Conscious Sprague-Dawley rats with myocardial infarction induced by left coronary artery ligation, or sham-ligated (SL) controls were infused intracerebroventricularly with artificial cerebrospinal fluid (aCSF), ANG II, ANG II + VP or ANG II + V1a receptor antagonist (V1ANT) 4 weeks after cardiac surgery. In the infarcted but not in the SL rats, the resting mean arterial blood pressure (MABP) was significantly elevated by infusions of ANG II and ANG II + VP, while infusion of ANG II + V1ANT was not effective. During administration of aCSF, the pressor, and tachycardic responses to an air-jet stressor were significantly greater in the infarcted than in the SL rats. In the SL rats, the pressor responses to the stressor were significantly greater during infusions of ANG II, ANG II + VP and ANG II + V1ANT than during infusion of aCSF. The tachycardic response in the SL rats was enhanced only by the combined infusion of ANG II + VP. In the infarcted rats, the pressor and the tachycardic responses to the stressor were similar in all groups. It is concluded that: (1) under resting conditions the infarcted rats manifest sensitisation to the central pressor effect of ANG II and that this effect depends on concomitant stimulation of V1a VP receptors, (2) central ANG II may enhance the pressor response to an alarming stressor in the SL rats through an action which does not depend on the concomitant stimulation of V1a receptors, (3) the cooperative action of ANG II and VP is required for intensification of the tachycardic response to the alarming stressor in the SL rats and (4) exaggeration of the cardiovascular responses to the alarming stressor in the infarcted rats cannot be further augmented by an additional stimulation of central ANG II receptors or combined stimulation of ANG II and VP receptors.     

Explanation and Understanding: Action as “Historical Structure”

The first part of this essay is basically historical. It introduces the explanation–understanding divide, focusing in particular on the general–unique distinction. The second part is more philosophical and it presents two different claims on action. In the first place, I will try to say what it means to understand an action. Secondly, we will focus on the explanation of action as it is seen in some explanatory sciences. I will try to argue that in some cases these sciences commit what I call an “external contradiction”.

Women are not less field independent than men—the role of stereotype threat

Prior research has shown that females are less field independent (FI) than males. However, when gender identity is salient, performance on tests assessing constructs similar to FI may be hindered, because of stereotype threat. This study examined the impact of stereotype threat on gender differences in FI. We expected that (a) reporting one's own gender prior to FI testing and (b) having an opposite‐gender experimenter would activate stereotype threat, and in turn result in lower performance on a test of FI among females. Overall, 170 participants were randomly assigned to one of eight conditions in a between‐participants design varying the participant's gender, experimenter's gender and timing of the gender question (before vs. after test). Results showed that reporting one's gender before the FI test led to lower FI performance among females. Furthermore, females achieved higher FI when experimenters were females and gender questions were administered after the FI test.     

Philosophical parrhesia as aesthetics of existence

According to some interpreters, Foucault's encounter with the Greek and Roman ethics led him to reconsider his earlier work and to turn away from politics. Drawing mostly from Foucault's last and hitherto unpublished lecture course, this paper argues that Foucault's turn to ethics should not be interpreted as a turn away from his previous work, but rather as its logical continuation and an attempt to resolve some of the outstanding questions. I argue that the 1984 lectures on parrhesia should be interpreted as Foucault's philosophical apology, as an attempt to defend himself against the charges of moral and epistemological nihilism, which were raised in response to his earlier work. In his last lectures, the Nietzschean Foucault somewhat surprisingly describes his earlier work as authentic Socratic philosophy and as ethical practice of freedom. In the conclusion, I assess the plausibility of Foucault's apology and speculate in which direction his work might have developed, had it not been cut off by his death.     

Naïve realism about unconscious perception

Synthese - Recently, it has been objected that naïve realism is inconsistent with an empirically well-supported claim that mental states of the same fundamental kind as ordinary conscious...     

The effect of navigation method and visual display on distance perception in a large-scale virtual building

Cognitive Processing - Immersive virtual reality (VR) technology has become a popular method for fundamental and applied spatial cognition research. One challenge researchers face is emulating...     

Location,Location, Location: Effects of Cross-Religious Primes on Prosocial Behavior

Priming with religious concepts is known to have a positive effect on prosocial behavior; however, the effects of religious primes associated with outgroups remain unknown. To explore this, we conducted a field experiment in a multicultural, multireligious setting (the island of Mauritius). Our design used naturally occurring, ecologically relevant contextual primes pertinent to everyday religious and secular life while maintaining full experimental control. We found that both ingroup and outgroup religious contexts increased generosity as measured by a donation task. In accordance with previous research, we also found an interaction between individual religiosity and the efficacy of the religious primes. We discuss these findings and their interpretation, and we suggest potential avenues for further research.     

Working Memory Mechanism in Proportional Quantifier Verification

The paper explores the cognitive mechanisms involved in the verification of sentences with proportional quantifiers (e.g. “More than half of the dots are blue”). The first study shows that the verification of proportional sentences is more demanding than the verification of sentences such as: “There are seven blue and eight yellow dots”. The second study reveals that both types of sentences are correlated with memory storage, however, only proportional sentences are associated with the cognitive control. This result suggests that the cognitive mechanism underlying the verification of proportional quantifiers is crucially related to the integration process, in which an individual has to compare in memory the cardinalities of two sets. In the third study we find that the numerical distance between two cardinalities that must be compared significantly influences the verification time and accuracy. The results of our studies are discussed in the broader context of processing complex sentences.     

Eschewing Community: Black Metal

There is a great deal of literature that examines community orientations, in particular consumption‐based subcultures rooted in the appreciation of music scenes such as heavy metal and its subgenres. Much of this literature focuses on aspects of community maintenance, reaffirmation of shared identities and building of social bonds. In the present article, we report a study in which consumption of, and fandom in a specific scene in extreme metal, namely black metal, may lead to very unique consumer cultural orientations. Our analyses reveal that black metal fans' identities reside in a realm outside of a desired collective identification and tightly knit community, but rather one that uses signification, or representational means to convey meaning and belonging, as a way to signal repugnance with society and a reverence of individuality. The study engages a mixed qualitative approach utilizing interviews, observational research and content analysis to demonstrate how self‐identity related to the black metal music scene can thrive through an ideological and semiotic rejection of traditional community orientations seen in the majority of other extreme metal music scenes. This paper challenges traditional conceptualizations of group identity in music scenes by closely examining aspects of signification and fandom in black metal that represent a unique system of shared identities devoid of community building. Copyright © 2014 John Wiley & Sons, Ltd.     

Entrepreneurial Risk Taking Is Related to Mental Imagery: A Fresh Look at the Old Issue of Entrepreneurship and Risk

This paper contributes to the debate concerning determinants of willingness to take entrepreneurial risks and proposes a new approach to this issue. Our theoretical model predicts that entrepreneurs differ from non-entrepreneurs in their willingness to accept business risks because the former produce more vivid and more positive mental images of the consequences of risk taking than the latter. We investigated the psychological processes behind willingness to take business and non-business risks in groups of entrepreneurs and non-entrepreneurs. First, we measured basic risk attitudes. Next, participants were presented with risky scenarios and asked to: (1) produce mental images; (2) evaluate their positivity and vividness; and (3) assess fearfulness evoked by the scenarios as well as risk level and willingness to take risk. Entrepreneurs did not differ from non-entrepreneurs in either their basic risk attitudes or willingness to take non-business risks. However, entrepreneurs declared a greater readiness to take business risks and produced more positive and vivid mental images of business risks. We found that an indirect effect of vividness of mental imagery on declared business risk taking only occurred for entrepreneurs. On a theoretical level, our results show that mental imagery might determine entrepreneurs’ willingness to take business risk.