Basolateral amygdala inactivation impairs learned (but not innate) fear response in rats

Numerous studies have suggested that the amygdala is involved in the formation of aversive memories, but the possibility that this structure is merely related to any kind of fear sensation or response could not be ruled out in previous studies. The present study investigated the effects of bilateral inactivation of the amygdaloid complex in rats tested in the plus-maze discriminative avoidance task. This task concomitantly evaluates aversive memory (by discrimination of the two enclosed arms) and innate fear (by open-arm exploration). Wistar rats (3-5 months-old) were implanted with bilateral guide cannulae into basolateral amygdala. After surgery, all subjects were given 1 week to recover before behavioral experiments. Afterwards, in experiment 1, 15 min prior to training, 0.5 μl of saline or muscimol (1 mg/ml) was infused in each side via microinjection needles. In experiment 2 the animals received injections immediately after the training session and in experiment 3 rats were injected prior to testing session (24 h after training). The main results showed that (1) pre-training muscimol prevented memory retention (evaluated by aversive arm exploration in the test session), but did not alter innate fear (evaluated by percent time in open arms); (2) post-training muscimol impaired consolidation, inducing increased percent in aversive arm exploration in the test session and (3) pre-testing muscimol did not affect retrieval (evaluated by aversive enclosed arm exploration in the test session). The results suggest that amygdala inactivation specifically modulated the learning of the aversive task, excluding a possible secondary effect of amygdala inactivation on general fear responses. Additionally, our data corroborate the hypothesis that basolateral amygdala is not the specific site of storage of aversive memories, since retention of the previously learned task was not affected by pre-testing inactivation.     

Brazelton Neonatal Behavioral Assessment Scale: A psychometric study in a Portuguese sample

BackgroundThe Neonatal Behavioral Assessment Scale (NBAS, Brazelton &; Nugent, 1995) is an instrument conceived to observe the neonatal neurobehavior. Data analysis is usually performed by organizing items into groups. The most widely used data reduction for the NBAS was developed by Lester, Als, and Brazelton (1982).ObjectiveExamine the psychometric properties of the NBAS items in a sample of 213 Portuguese infants.MethodThe NBAS was performed in the first week of infant life (3 days ± 2) and in the seventh week of life (52 days ± 5).ResultsPrincipal component analyses yielded a solution of four components explaining 55.13% of total variance. Construct validity was supported by better neurobehavioral performance of 7-week-old infants compared with 1-week-old infants.ConclusionChanges in the NBAS structure for the Portuguese sample are suggested compared to Lester factors in order to reach better internal consistency of the scale.     

Grammatical and nongrammatical contributions to closed-class word selection

Closed-class word selection was investigated by focusing on determiner production. Native speakers from three different languages named pictures of objects using determiner plus noun phrases (e.g., in French "la table" [the-sub(feminineA) table], while ignoring distractor determiners printed on the pictures (e.g., "le" [the-sub(masculine)]. The target and distractor expressed either shared or different grammatical and nongrammatical features (gender, number, and definiteness). A gender-facilitation effect was observed and attributed to noun processing. Crucially, across five experiments, distractors that shared a feature with the target determiner never resulted in longer naming latencies than distractors that were more different. These results indicate that activating related candidates is not detrimental for determiner retrieval, suggesting a noncompetitive mechanism of closed-class word selection.     

Does bilingualism hamper lexical access in speech production?

In the present study, we tested the hypothesis that bilingualism may cause a linguistic disadvantage in lexical access even for bilinguals' first and dominant language. To this purpose, we conducted a picture naming experiment comparing the performance of monolinguals and highly-proficient, L1-dominant bilinguals. The results revealed that monolinguals name pictures faster than bilinguals, both when bilinguals perform picture naming in their first and dominant language and when they do so in their weaker second language. This is the first time it has been demonstrated that bilinguals show a naming disadvantage in their L1 in comparison to monolingual speakers.     

Personality trait similarity between spouses in four cultures

We examined patterns of trait similarity (assortative mating) in married couples in four cultures, using both self-reports and spouse ratings on versions of the Revised NEO Personality Inventory. There was evidence of a subtle but pervasive perceived contrast bias in the spouse-rating data. However, there was strong agreement across methods of assessment and moderate agreement across cultures in the pattern of results. Most assortment effects were small, but correlations exceeding .40 were seen for a subset of traits, chiefly from the Openness and Agreeableness domains. Except in Russia, where more positive assortment was seen for younger couples, comparisons of younger and older cohorts showed little systematic difference. This suggested that mate selection, rather than convergence over time, accounted for similarity. Future research on personality similarity in dyads can utilize different designs but should assess personality at both domain and the facet levels.     

Systemic administration of a nitric oxide synthase inhibitor impairs fear sensitization in the plus-maze

The aim of the present study was to evaluate the occurrence of fear sensitization in rats previously treated with an inhibitor of the NO syntheses and submitted to Trial1/Trial2 plus-maze (PM) procedure. Male Wistar rats received a systemic treatment with N(omega)-nitro-L-Arginine-methyl ester (L-NAME; 5, 10 or 50 mg kg(-1)) and were submitted to PM Trial1. In the following day the animals were re-exposed to the PM with no drug administration (Trial2). Some standards spatial-temporal measures, such as the percentage of entries (% Open arm entries) and time spent (% Open arm time) in the open arms and risk assessment frequency were recorded and used to estimate the animal level of fear sensitization in PM Trial2. The results showed that animals receiving L-NAME (50 mg kg(-1)) displayed increased % Open arm entries and % Open arm time in Trial2 in relation to the group receiving 0.9% saline, which is compatible with impaired fear/anxiety acquisition during Trial1/Trial2 PM procedure. In addition, rats treated with L-NAME (50 mg kg(-1)) exhibited low level of risk assessment in Trial2 in relation to the group treated with 0.9% saline, which indicates low level of fear/anxiety during PM re-exposure. The number of entries into the enclosed arms was not changed by any L-NAME treatment, which suggests no bias of the drug treatments on animal locomotor activity. The data suggest that NO synthesis may mediate the fear sensitization process in the PM.     

CONCURRENT RESURGENCE AND BEHAVIORAL HISTORY

The contribution of past experiences to concurrent resurgence was investigated in three experiments. In Experiment 1, resurgence was related to the length of reinforcement history as well as the reinforcement schedule that previously maintained responding. Specifically, more resurgence occurred when key pecks had been reinforced on a variable-interval 1-min schedule than a variable-interval 6-min schedule, but this effect may have been due either to the differential reinforcement rates or differential response rates under the two schedules. When reinforcement rates were similar (Experiment 2), there was more resurgence of high-rate than low-rate responding. When response rates were similar (Experiment 3), resurgence was not related systematically to prior reinforcement rates. Taken together, these three experimental tests of concurrent resurgence illustrate that prior response rates are better predictors of resurgence than are prior reinforcement rates.     

Rabbis and Health: A Half-Century Review of the Mental and Physical Health Care Literature:1950–1999

Electronic searches were conducted on PubMed and the American Psychological Association's database (PsycINFO) for articles that discussed the role of rabbis in relation to some aspect of healthcare. The two searches were conducted in each electronic database using the search-terms: (1) (rabbi OR rabbinical OR synagogue) OR (2) (Judaism OR Jewish) AND (clergy OR chaplain). Articles were classified by the year of their publication, professional discipline, type of journal (either religious or secular), and type of article: either research, or narrative and expositional. Rabbis were discussed most often in psychology, psychiatry, and behavior-related fields, and close to two-thirds of the articles dealt with mental health concerns. A statistically significant increase in articles across decades was found in the secular journals, r=.98, p≤.01, with over 70% of the articles about rabbis in the secular journals being published between 1980 and 1999. Many of the articles addressed collaboration between rabbis, psychiatrists, and other and mental health professionals and discussed previously identified themes related to professional collaboration and referral.     

Person‐factors in the California Adult Q‐Set: closing the door on personality trait types?

To investigate recent hypotheses of replicable personality types, we examined data from 1540 self‐sorts on the California Adult Q‐Set (CAQ). Conventional factor analysis of the items showed the expected Five‐Factor Model (FFM). Inverse factor analysis across random subsamples showed that none of the previously reported person‐factors were replicated. Only two factors were replicable, and, most importantly, these factors were contaminated by mean level differences in item endorsement. Results were not due to sample size or age heterogeneity. Subsequent inverse factor analysis of standardized items revealed at least three replicable factors; when five person‐factors were extracted, they could be aligned precisely with the dimensions of the FFM. The major factors of person similarity can be accounted for entirely in terms of the FFM, consistent with the hypothesis that there are no replicable personality types in the CAQ. Published in 2006 John Wiley & Sons, Ltd.     

The Quality of Home Environment in Brazil: An Ecological Model

Based on Bronfenbrenner's (1999) ecological perspective, a longitudinal, prospective model of individual differences in the quality of home environment (Home Observation for Measurement of the Environment—HOME) was tested in a sample of 179 Brazilian children and their families. Perinatal measures of family socioeconomic status (SES) and child birth weight had direct effects on HOME at preschool age. As either family SES or child birth weight increased, HOME also increased through diminished emotional distress in the mother a month following childbirth. SES had a negative effect on number of children in the household, which in turn had a long-term negative impact on HOME. Compared to mothers who had reported not to plan their pregnancy, those who did were more likely to have fewer children, to report more spouse support during childbearing, and to show less emotional distress a month after childbirth, all of which also influenced HOME at preschool age. These findings are discussed in light of the broader socio-ecological Brazilian context, with direct implications to clinical practice aimed at improving the quality of home environment.