The synergy of working memory and inhibitory control: behavioral, pharmacological and neural functional evidences

Concomitant deficits in working memory and behavioral inhibition in several psychiatric disorders like attention-deficit/hyperactivity disorder, addiction or mania, suggest that common brain mechanisms may underlie their etiologies. Based on the theoretical assumption that a continuum exists between health and mental disorders, we explored the relationship between working memory and inhibition in healthy individuals, through spontaneous inter individual differences in behavior, and tested the hypothesis of a functional link through the fronto-striatal dopaminergic system. Rats were classified into three groups, showing good, intermediate and poor working memory and were compared for their inhibitory abilities. These two functions were simultaneously modulated by a dose-effect of d-amphetamine and in situ hybridization was used to quantify dopaminergic receptor (RD1) mRNAs in prefrontal cortex and striatal areas. A functional relationship between working memory and inhibition abilities was revealed. Both functions were similarly modulated by d-amphetamine according to an inverted-U shaped relationship and depending on initial individual performances. D-amphetamine selectively improved working memory and inhibition of poor and intermediate performers at low doses whereas it impaired both processes in good performers at a higher dose. D1 receptors were less expressed in prelimbic, infralimbic and anterior cingulate cortices of good compared to intermediate and poor performers, whereas no difference was observed between groups in striatal areas. The synergy of working memory and inhibitory abilities, observed in both healthy and psychiatric populations, may originate from endogenous variability in dopaminergic prefrontal cortex activity. Such findings confirm the validity of a dimensional approach, based on the concept of continuity between health and mental disorders for identifying endophenotypes of mental disorders.     

Collaborative partner or social tool? New evidence for young children’s understanding of joint intentions in collaborative activities

Some children’s social activities are structured by joint goals. In previous research, the criterion used to determine this was relatively weak: if the partner stopped interacting, did the child attempt to re‐engage her? But re‐engagement attempts could easily result from the child simply realizing that she needs the partner to reach her own goal in the activity (social tool explanation). In two experiments, 21‐ and 27‐month‐old children interacted with an adult in games in which they either did or did not physically need the partner to reach a concrete goal. Moreover, when the partner stopped interacting, she did so because she was either unwilling to continue (breaking off from the joint goal) or unable to continue (presumably still maintaining the joint goal). Children of both age groups encouraged the recalcitrant partner equally often whether she was or was not physically needed for goal attainment. In addition, they did so more often when the partner was unable to continue than when she was unwilling to continue. These findings suggest that young children do not just view their collaborative partners as mindless social tools, but rather as intentional, cooperative agents with whom they must coordinate intentional states.     

When local processing increases the appeal of healthy options

People often encounter self-control challenges in complex everyday environments in which objects that promote a given goal (e.g., to eat healthily) are mixed together with objects that obstruct that goal. For example, healthy and unhealthy food choices are often mixed together in restaurant menus. Because local processing facilitates attention to low-level details, we expect that it may play an important role in these complex situations. In the present studies, we test the hypothesis that local processing supports self-control when goal items and temptations are contextually paired. As predicted, our findings revealed that local processing (relative to global processing) increased evaluations of healthy items when those items were presented together with unhealthy items. As hypothesized, this effect of local processing only occurred when healthy and unhealthy foods were presented as complementary – not competing – options, suggesting that local processing may increase evaluations of healthy options by decreasing the extent to which individuals accept environmental cues that healthy and unhealthy foods belong together. These findings support recent research demonstrating that despite strong evidence of the advantages of global processing for self-control, local processing may also support self-control efforts in some important everyday situations.     

Lower extremity strength and hopping and jumping ground reaction forces in children with neurofibromatosis type 1

The purpose of this study was to (1) extend the research findings of decreased muscular force production in grip strength to the lower extremity strength of children with NF1 and (2) to determine if there was a relationship between isometric strength and functional activities in children with NF1. Force production was assessed using a hand held dynamometer (HHD) and a functional task (hopping and jumping) on a force plate. Data from twenty-six children with NF1 were compared to data from 48 typically developing children of similar sex, weight and height. Children with NF1 demonstrated statistically significant lower force production with HHD (p<0.01) during hip extension, but similar force production for knee extension and ankle plantar flexion compared to the control group. A relationship existed between the ground reaction forces at take-off from both hopping and jumping and the force generated from knee extensor strength in the NF1 group. The addition of a functional task to hand held dynamometry is useful for determining a relationship between common clinical measures and functional activities.     

Identity construction and career development interventions with emerging adults

Today's wealthy societies are more fluid, varied and complex than they were just a few decades ago. As a consequence, what were “vocational choices” at the beginning of the 20th century now appear as “life designing issues”. In this context, contemporary research stresses the plurality and relative malleability of human subjects as well as their ability to take reflexive stances on their current and past experiences. Fitting in such an epistemology, a self-constructing model is proposed as a basis for a life designing counseling interview. This model describes self-identity as a dynamic system of (past, present and expected) subjective identity forms (SIF), the synthesis and dynamism of which originate in a tension between two kinds of reflexivity. Counseling interviews with emerging adults show that the elicitation of some expected SIF allows them to re-read their current and past experiences from such a perspective and constitutes a compelling incentive to act.     

Lunacy and Scepticism: Notes on the Logic of Doubt Concerning the Existence of an External World

This article develops a logical (or semantic) response to scepticism about the existence of an external world. Specifically, it is argued that any doubt about the existence of an external world can be proved to be false, but whatever appears to be doubt about the existence of an external world that cannot be proved to be false is nonsense, insofar as it must rely on the assertion of something that is logically impossible. The article further suggests that both G. E. Moore and Ludwig Wittgenstein worked towards the same solution but left their work unfinished.

     

Correction to: A psychophysiological investigation of mourning: There are two sides to the story

Motivation and Emotion - Mourning constitutes an important human emotion, which might cause—among other things—major depressive symptoms when lasting for too long. To date, no study...     

The interplay of math anxiety and math competence for later performance

Social Psychology of Education - Math anxiety’s negative effects on performance are well-documented. The interplay of math anxiety and mathematical competence regarding later performance is...