颈动脉病变的治疗现状

颈动脉病变尤其是颈动脉狭窄治疗上的分歧,颈动脉内膜切除术受欧美学者推崇,颈动脉支架成形技术受国内学者青睐,本文就近年来的文献复习发现颈动脉内膜切除术和颈动脉支架成形术各有相宜的适应证.各有优缺点,根据各自医院的设备条件、医师对颈动脉内膜切除术和颈动脉支架成形术熟悉程度来开展工作,对颈动脉狭窄治疗均有益处,存在的问题和困难还需进一步完善.     

Measuring Parenting in Community and Public Health Research Using Brief Child and Parent Reports

The use of multi-method, multi-informant assessment is a hallmark of research in child development and mental health; however, many research strategies such as population surveys require brief assessment tools. The Alabama Parenting Questionnaire (APQ) is a popular measure of empirically identified aspects of positive and negative parenting styles important to conduct problems in children. A brief version exists, however it does not measure all relevant parenting domains, and it has not been validated for child reports. We evaluated validity of the brief parent and child report version of the complete five subscale version of the APQ in a sample of 208 children aged between 9 and 17, at risk for conduct problems and antisocial behaviour. The results showed that all five dimensions of parenting can be measured using a brief 15 item version; specifically child and parent reports converged as expected and discriminated high from low conduct problem children using parent and teacher reports. Only child reports converged with independent observations of parenting behaviour, supporting previous research showing that child reports of parenting are particularly important. Finally, results did not support the typical methods used for combining child and parent reports into one index.     

Visual perceptual learning

Perceptual learning refers to the phenomenon that practice or training in perceptual tasks often substantially improves perceptual performance. Often exhibiting stimulus or task specificities, perceptual learning differs from learning in the cognitive or motor domains. Research on perceptual learning reveals important plasticity in adult perceptual systems, and as well as the limitations in the information processing of the human observer. In this article, we review the behavioral results, mechanisms, physiological basis, computational models, and applications of visual perceptual learning.     

Block of glucocorticoid synthesis during re-activation inhibits extinction of an established fear memory

BackgroundThe pharmacology of traumatic memory extinction has not been fully characterized despite its potential as a therapeutic target for established, acquired anxiety disorders, including post-traumatic stress disorder (PTSD). Here we examine the role of endogenous glucocorticoids in traumatic memory extinction.MethodsMale C57BL/6J mice were injected with corticosterone (10 mg/kg, i.p.) or metyrapone (50 mg/kg, s.c.) during re-activation of a contextual fear memory, and compared to vehicle groups (N = 10–12 per group). To ensure that metyrapone was blocking corticosterone synthesis, we measured corticosterone levels following re-activation of a fear memory in metyrapone- and vehicle-treated animals.ResultsCorticosterone administration following extinction trials caused a long-lasting inhibition of the original fear memory trace. In contrast, blockade of corticosteroid synthesis with metyrapone prior to extinction trials enhanced retrieval and prevented extinction of context-dependent fear responses in mice. Further behavioral analysis suggested that the metyrapone enhancement of retrieval and prevention of extinction were not due to non-specific alterations in locomotor or anxiety-like behavior. In addition, the inhibition of extinction by metyrapone was rescued by exogenous administration of corticosterone following extinction trials. Finally, we confirmed that the rise in corticosterone during re-activation of a contextual fear memory was blocked by metyrapone.ConclusionsWe demonstrate that extinction of a classical contextual fear memory is dependent on endogenous glucocorticoid synthesis during re-activation of a fear memory. Our data suggest that decreased glucocorticoids during fear memory re-activation may contribute to the inability to extinguish a fear memory, thus contributing to one of the core symptoms of PTSD.     

Intentional self-regulation, ecological assets, and thriving in adolescence: a developmental systems model

The positive youth development (PYD) perspective emphasizes that thriving occurs when individual ?context relations involve the alignment of adolescent strengths with the resources in their contexts. The authors propose that a key component of this relational process is the strength that youth possess in the form of self-regulatory processes; these processes optimize opportunities to obtain ecological resources that enhance the probability of PYD. They use the selection, optimization, and compensation (SOC) model of intentional self-regulation to discuss the role of self-regulation in the PYD perspective among diverse youth.     

What Matters for Well-Being: Individual Perceptions of Quality of Life Before and After Important Life Events

In recent decades, what matters for individual quality of life (QoL) has increasingly been the focus of empirical social science research. However, individuals are rarely asked directly what is important for their quality of life as part of large-scale surveys. The present analysis studies perceptions of what matters for QoL in a large-scale longitudinal dataset—the British Household Panel Survey—which includes an open-ended question on QoL in three waves spanning ten years. We find that concepts of QoL change over the life course and differ between men and women. We hypothesize that changes in perceptions of QoL are related to important life events, such as the birth of a first child and retirement. These life events constitute ’turning points’ after which individuals often shift their priorities of what matters for their QoL. We further explore whether such shifts in priorities are stable or disappear more than five years after the life event.     

A Pilot Study of Psychotherapist Trainees' Alpha-Amylase and Cortisol Levels During Treatment of Recently Suicidal Clients With Borderline Traits

Psychotherapists often experience stress while providing psychotherapy, in particular when working with difficult presentations such as suicidality. As part of a larger study on the treatment of recently suicidal college students with borderline traits, 6 therapists in training collected their own salivary samples for alpha-amylase (AA) and cortisol (C) analyses immediately before and after sessions with 2 selected clients. On average, samples were collected for the same therapist-patient dyad throughout the year-long study to ensure that data reflected therapist responses across stages of treatment. Therapists also completed a working alliance questionnaire and rated perceived session difficulty immediately after each selected session. Contrary to expectations, therapists demonstrated elevated levels of stress as measured by AA and C at presession relative to postsession levels. Greater session difficulty was related to more pronounced declines in AA, whereas a stronger working alliance was linked to more pronounced reductions in C. Results suggest that physiological stress responses while working with recently suicidal clients with borderline traits occur primarily in terms of session anticipatory anxiety, whereas AA and C changes may be affected differently by factors such as session difficulty and working alliance. This is a pilot study, limited by its sample size, but the design, findings, and inclusion of physiological measures present an initial step in an essential line of research.     

回族穆斯林"尔曼里"文化解析

尔曼里作为回族文化的一部分,有着多元的文化类型,是伊斯兰教中国本土化的产物,在中国回族多元教派门宦的社会中,尔曼里具有着地域性和教派门宦的特征,其多元的文化类型是回族人多元认同的中国化表达。笔者认为,尔曼里作为一种回族民俗与宗教兼顾的族群行为,其形成的特定场景和历程决定着这一华俗存在的合理性。     

康德遗著——遗世手稿、康德的工作方式和遗稿新编

康德的《遗著》包含着康德的从自然的理性形而上学向经验科学过渡的未完成的哲学计划,《康德全集》中原有的非批判的版本存在着诸多欠缺,因此新的版面采用发生学的结构分析,通过对康德的工作方式的考察,重现了康德的凌乱而又被密集书写的手稿上的文字产生的时间顺序和逻辑关系,从而最大限度地还原了康德对这一问题的整个思考过程。     

脑信号导向蛋白Semaphorins3F与难治性癫痫

在神经发育过程中Semaphorins为轴突导向和神经细胞的迁移提供导向信息。这些导向分子通过抑制自发的或异常的轴突生长来维持己建立的神经连接,并参与突触可塑性以及中枢神经受损后抑制神经再生与神经细胞的死亡。目前,虽然对Semaphorins在神经发育、成熟及受损不同阶段中的功能己有初步的了解,但Semaphorins其受体多样,尚无法预测Sema-phorins与其受体的结合将产生的生物学效应以及Semaphorins在神经系统中起作用的分子机制。进一步研究Semaphorins对癫痫、精神分裂、老年痴呆症等神经系统性疾病的治疗具有深远意义。