Hyperactivity and Learning Deficits in Transgenic Mice Bearing a Human Mutant Thyroid Hormone β1 Receptor Gene

Resistance to thyroid hormone (RTH) is a human syndrome mapped to the thyroid receptor β (TRβ) gene on chromosome 3, representing a mutation of the ligandbinding domain of the TRβ gene. The syndrome is characterized by reduced tissue responsiveness to thyroid hormone and elevated serum levels of thyroid hormones. A common behavioral phenotype associated with RTH is attention deficit hyperactivity disorder (ADHD). To test the hypothesis that RTH produces attention deficits and/or hyperactivity, transgenic mice expressing a mutant TRβ gene were generated. The present experiment tested RTH transgenic mice from the PV kindred on behavioral tasks relevant to the primary features of ADHD: hyperactivity, sustained attention (vigilance), learning, and impulsivity. Male transgenic mice showed elevated locomotor activity in an open field compared to male wild-type littermate controls. Both male and female transgenic mice exhibited impaired learning of an autoshaping task, compared to wild-type controls. On a vigilance task in an operant chamber, there were no differences between transgenics and controls on the proportion of hits, response latency, or duration of stimulus tolerated. On an operant go/no-go task measuring sustained attention and impulsivity, there were no differences between controls and transgenics. These results indicate that transgenic mice bearing a mutant human TRβ gene demonstrate several behavioral characteristics of ADHD and may serve a valuable heuristic role in elucidating possible candidate genes in converging pathways for other causes of ADHD.     

Nietzsche and decadence: The revaluation of morality

The creation of moralities is necessary for the enhancement of the species, yet, the assigning of values is a sign of decadence. According to Nietzsche, this is the problem of decadence with which human beings (in particular philosophers) must contend: they must place a value on life, but placing a value on life (even on one's individual life) is problematic because it involves fracturing the whole of life into pieces. The primary objective in this paper is to address Nietzsche's own battle with the problem of decadence as it applies to individuals. I will argue that in this battle, Nietzsche carried out a revaluation of decadence and transformed himself into a strong decadent. In calling himself a strong decadent, Nietzsche not only admitted to his own decadence, but also provided himself as an example for how other strong types might contend with the problem of decadence.     

Memory in reading and listening to discourse

After reading or listening to short passages, Ss attempted to recognize semantically changed sentences and paraphrases (syntactically and lexically changed sentences). The intervals between the original presentation and test ranged from 1 to 23 sec. In general, paraphrases were poorly detected after a brief time, supporting earlier findings that the exact wording of sentences is not stored in long-term memory. An exception was the high recognition of active-passive changes with the visual presentation. Recognition at the first test interval was significantly better after listening than after reading, although the eventual level of recognition memory was not different in the two modes. This result, consistent with other studies of modality effects in short-term memory, suggests that acoustic-phonetic memory played a role in the storage of the auditorally presented material.     

Dynamic Relational Group Psychotherapy: A Neurobiologically Informed Model of Change

In this article, we introduce a preliminary, neurobiologically informed model of group therapy that links the timing and nature of specific group interventions with hypothesized changing neurobiological needs of the group. We suggest that the observed phases of group development reflect an underlying reorganization of neuronal circuitry that occurs as members progress through a hierarchically organized treatment, and that this reorganization involves the integration and homeostatic rebalancing of subcortical and neural networks. Our preliminary Dynamic Relational Model suggests that an understanding of the neurobiological processes involved in group development may help inform and direct effective group-based psychotherapy interventions.     

Inheriting the Shadow: Unlived Lives,Unshed Tears

The determination and courage of those whose lives were destroyed by terror, whether the Holocaust or extermination, to move forward in a new life modeled for us, the children, an unspoken mandate to live in the present and to bury the shadows of the past. It has left many of us to face the challenge of finding our center, the anchoring of our being in our lives: personally, professionally, collectively, and culturally. The next generation is not able to mourn lives lost, and being in the present without a past, without links to ethnic cultures or heritage, isolates individuals and affects the collective—indeed, there is no collective except in the communal silences. This article explores the impact of dismembered personal and collective bonds and the need to re-member, resulting in relationships that can move into the future, into the center.     

The association of tanning behavior with psycho-tropic medication use among young adult women

Despite its known association with skin cancer, tanning remains popular among young adult women. Indoor tanning behavior has been found to be associated with affective and addictive disorders. To better understand potential psychological and biological mechanisms of tanning behavior, we investigated associations between tanning and medication (psychotropic and other) use among young women. Two hundred and fifty-three women age 18–29 years old were recruited from two northeastern university campus communities. Women self-reported tanning frequency and chronic medication use. In both univariate and multivariate analyses, indoor tanning ≥12 times last year was significantly associated with use of psychotropic medication and anti-depressants in particular. Sunbathing was not associated with medication use. Potential reasons for associations between tanning and psychotropic medication use are discussed. Indoor tanners should be warned that some psychotropic medications are photosensitizing, thus increasing risk for burns and other skin damage from indoor tanning.     

Tú velas por los tuyos: Weak Labor Markets and the Importance of Social Networks

Literature on the economic incorporation of immigrants to new destinations has been missing a discussion on how the strength of the local economy affects immigrants’ need for social networks and how it might also affect the relative importance of strong versus weak ties for immigrant job seekers. Through the use of in-depth interviews, the role and importance of social networks in the labor market incorporation of Hispanic immigrants in economically weak cities is examined, as well as the consequences to those immigrants who are unable to command or lack access to social networks and/or ethnic resources. This paper contextualizes the importance of strong ties for immigrants in economically weak new destinations and argues that in places with such a constricted labor market and stagnant economies, it is imperative for recent arrivals to access and/or construct these strong ties in order to more effectively gain entry into the host society’s labor market.     

Spatial Proportional Reasoning Is Associated With Formal Knowledge About Fractions

Proportional reasoning involves thinking about parts and wholes (i.e., about fractional quantities). Yet, research on proportional reasoning and fraction learning has proceeded separately. This study assessed proportional reasoning and formal fraction knowledge in 8- to 10-year-olds. Participants (N = 52) saw combinations of cherry juice and water in displays that highlighted either part–whole or part–part relations. Their task was to indicate on a continuous rating scale how much each mixture would taste of cherries. Ratings suggested the use of a proportional integration rule for both kinds of displays, although more robustly and accurately for part–whole displays. The findings indicate that children may be more likely to scale proportional components when being presented with part–whole as compared with part–part displays. Crucially, ratings for part–whole problems correlated with fraction knowledge, even after controlling for age, suggesting that a sense of spatial proportions is associated with an understanding of fractional quantities.