Effects of chronic variable stress and antidepressant drugs on behavioral inactivity during an uncontrollable stress: interaction between both treatments.

Rats submitted to a chronic variable stress regime exhibited more inactivity during inescapable shock as compared with unstressed rats. Besides, chronic treatments with desipramine, imipramine, clomipramine, or phenelzine reduce the amount of inactivity exhibited during this aversive experience. Furthermore, the combination of both chronic treatments--stress and antidepressants--resulted in a potentiation of the antidepressant effect alone. This higher antidepressant efficacy may result from the interaction of the neural mechanisms triggered by chronic stress exposure and antidepressant drugs.     

A flavor paired with lithium chloride blocks the formation of a pentobarbital-lithium chloride association

Thirsty rats were used in order to determine whether a vinegar solution, which had been paired with an injection of lithium chloride, could block the formation of an association between a pentobarbital- and a lithium chloride-induced state. During phase 1 the rats in the blocking group had a 2.0% vinegar solution paired with an injection of 240 mg/kg of lithium chloride, during phase 2 these rats were reexposed to the vinegar prior to each injection of 20 mg/kg of pentobarbital and 240 mg/kg of lithium chloride, and during phase 3 these rats were given access to a novel 0.75% saccharin solution and were injected with pentobarbital after saccharin removal. Animals with this history did not form an association between the pentobarbital- and lithium chloride-induced states during phase 2 as evidenced by their refusal to consume the saccharin solution over repeated pairings of saccharin with pentobarbital during phase 3. Control groups that received forward pairings of pentobarbital and lithium chloride, in the absence of a previously conditioned vinegar solution during phase 2, formed an association between pentobarbital and lithium chloride. These findings indicate that drug states and flavors can interfere with each others' capacity to predict the occurrence of lithium chloride.     

Semantic congruity effects in perceptual comparisons

Semantic congruity effects occur when, as in Experiment 1, for example, the time to select the shorter of two relatively short lines is faster than the time to select the longer; conversely, selection of the longer of two relatively long lines is faster than selection of the shorter. Semantic congruity effects are also demonstrated in experiments requiring comparisons of the heaviness of weights (Experiment 2) and horizontal extent (Experiment 3). In Experiment 1, the magnitude of the semantic congruity effect was larger under conditions emphasizing accuracy rather than speed and when the comparison was difficult. In fact, when comparisons were errorless, the effect was minimal (20 msec), thereby replicating previous failures to obtain the effect with supraliminal perceptual comparisons (Banks, Mermelstein, & Yu, 1982; Marschark & Paivio, 1981; Petrusic & Baranski, 1988a). In confirmation of Henmon's (1911) introspective analyses of psychophysical comparisons, Experiments 2 and 3 extend the range of the semantic congruity effect to include judgments of confidence. However, in each of the three experiments, semantic congruity effects were not evident with the response-accuracy measure. Finally, using highly confusable stimuli, in Experiment 3 the magnitude of the semantic congruity effect was shown to be larger for error than for correct response times. The implications of these findings for a decisional locus of the effect and for the semantic coding theory are discussed.     

Patterns of movement in the first 6 months of life: new directions

The field of infant perceptual development has relied heavily on the preferential-looking and habituation paradigms. Despite the obvious advantages of employing standardized methodologies, there is a need to study how perceptual variables give rise to and guide action beginning in the neonatal period. It is argued here that, in the first 5 months of life, it is important to distinguish reflexive patterns of movement from voluntary and cortically controlled patterns. Some criteria are defined. This paper describes three experiments which utilized movement counters to record developmental changes in the frequency and synchrony of limb movements in infants under 5 months. The results show that there is a general increase in frequency of limb movements from 1 to 5 months, but with a plateau or even a decrease in activity from the middle of the third month to the end of the fourth month. It was also demonstrated that synchrony scores (co-activation) for pairs of limbs showed significant increases from 1 month to 5 months. Finally, in all three experiments the presentation of an attractive toy resulted in suppression of activity. The results of the three experiments are interpreted to measure a gradual increase in cortically controlled movement patterns.     

An exploratory study of planning, attention, simultaneous, and successive cognitive processes

Although there has been a considerable amount of research on simultaneous and successive processing (Luria's second functional unit) by Das and others, there have been relatively few investigations into the measurement of attention and planning (the first and third functional units, respectively). The purpose of this investigation was to examine the factorial validity of tasks designed to measure cognitive processing in each of Luria's three functional units. A sample of 112 normal fourth- and fifth-grade students were administered nine experimental tasks chosen or developed according to the theoretical components of planning, attention, simultaneous, and successive processes. Principal factor analyses (orthogonal and oblique) with rotation of four factors resulted in solutions that closely matched the anticipated groupings based on a structural analysis of the tasks. General support for the feasibility of measurement of Luria's cognitive processing model, and the need to further develop and refine these and other experimental tasks, was obtained.     

Topographic electroencephalographic alpha in recovered depressed elderly

Late-middle-aged and elderly normal volunteers with past histories of Major Depression according to the Diagnostic and Statistical Manual of Mental Disorders (third edition-revised) criteria were compared with sex- and age-matched control subjects using topographic electroencephalographic (EEG) indices. Healthy, euthymic recovered depressed subjects showed greater alpha amplitudes than controls. Delta, theta, and beta amplitudes did not reliably distinguish the groups. Considered in the context of previous research indicating that actively depressed subjects exhibit elevated EEG alpha compared to controls, these findings raise questions concerning state and trait conceptualizations of depression and EEG alpha.     

Eyewitness accuracy and confidence: within- versus between-subjects correlations

Previous researchers using between-subjects comparisons have found eyewitness confidence and accuracy to be only negligibly correlated. In this study, we examined the predictive power of confidence in within-subject terms. Ninety-six subjects answered, and made confidence ratings for, a series of questions about a crime they witnessed. The average between-subjects and within-subject accuracy-confidence correlations were comparably low: r = .14 (p less than .001) and r = .17 (p less than .001), respectively. Confidence is neither a useful predictor of the accuracy of a particular witness nor of the accuracy of particular statements made by the same witness. Another possible predictor of accuracy, response latency, correlated only negligibly with accuracy (r = -.09 within subjects), but more strongly with confidence (r = -.27 within subjects). This pattern was obtained for both between-subjects and within-subject comparisons. The theoretical and practical implications of these results are discussed.