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91.
Coulehan J 《The Journal of medical humanities》2004,25(3):223-233
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Substantial evidence suggests that alterations in noradrenergic function contribute to the cognitive impairments of schizophrenia. Activation of post-junctional alpha 2a-adrenergic receptors in the prefrontal cortex by the alpha 2a-selective agonist guanfacine has demonstrated some preliminary benefit in subjects with schizophrenia treated with atypical antipsychotics. alpha 1-adrenergic receptor activity may be less important in mediating the cognitive impairments of schizophrenia. beta-adrenergic receptors may serve as another potential target for cognitive remediation in schizophrenia. However, the potential increase in memory consolidation in schizophrenia patients produced by beta-adrenergic agonists may be outweighed by the impairment in cognitive flexibility and executive functioning produced by beta-adrenergic agonists. Finally, norepinephrine reuptake inhibitors, such as atomoxetine, hold promise as potential cognitive enhancers in schizophrenia because of their ability to indirectly but selectively increase extracellular dopamine concentrations in the prefrontal cortex. 相似文献
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Sex differences for selective forms of spatial memory 总被引:1,自引:0,他引:1
In the present study, a systematic comparison of sex differences for several tests of spatial memory was conducted. Clear evidence for more accurate male performance was obtained for precise metric positional information in a wayfinding task and in an object location memory task. In contrast, no sex difference characterized topological information processing (object-to-position assignment). Together, these findings provide further insight in the specificity of sex differences in spatial memory and in the functional architecture of spatial memory. Implications for the relevant evolutionary basis are discussed. 相似文献
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The authors examined whether three indicators of Schizotypy, the Revised Social Anhedonia Scale (RSAS), Magical Ideation Scale (MIS), and Perceptual Aberration Scale (PAS), identify a common latent class or taxon as conceptualized by P. E. Meehl (1962, 1990). The separate and joint latent structures of these scales were evaluated using taxometric methods in two large, independent samples. Replicating prior findings, the RSAS and PAS each identified latent taxa with base rates approximating.10. Results for the taxonicity of the MIS were less consistent. Analyses of joint latent structure indicated that the RSAS-identified taxon was essentially independent of constructs measured by the PAS or MIS. Measures commonly thought to tap the same latent class, conjectured to be schizotypy, do not share this property. 相似文献