The neurobiology of postpartum depression

Postpartum psychiatric changes can range from maternity blues to psychosis. Causality is still undetermined, but explanations for these disturbances often focus on hormonal changes and dysregulation. Researchers have begun the process of delineating what neurobiological factors may be associated with depressive disorders in pregnancy and the postpartum. This article reviews the current literature on the roles of gonadal and pituitary hormones in the psychopathophysiology of postpartum mood disorders. Other biological factors, such as biogenic amines, neuroactive steroids, cholesterol, and fatty acids, are also discussed. The potential benefits of neuroimaging to aid in understanding neuropsychiatric changes that occur in the context of postpartum depression are also considered.     

Teaching for adaptive expertise in biomedical engineering ethics

This paper considers an approach to teaching ethics in bioengineering based on the How People Learn (HPL) framework. Curricula based on this framework have been effective in mathematics and science instruction from the kindergarten to the college levels. This framework is well suited to teaching bioengineering ethics because it helps learners develop “adaptive expertise”. Adaptive expertise refers to the ability to use knowledge and experience in a domain to learn in unanticipated situations. It differs from routine expertise, which requires using knowledge appropriately to solve routine problems. Adaptive expertise is an important educational objective for bioengineers because the regulations and knowledge base in the discipline are likely to change significantly over the course of their careers. This study compares the performance of undergraduate bioengineering students who learned about ethics for stem cell research using the HPL method of instruction to the performance of students who learned following a standard lecture sequence. Both groups learned the factual material equally well, but the HPL group was more prepared to act adaptively when presented with a novel situation.     

Pancultural self-enhancement reloaded: a meta-analytic reply to Heine (2005)

C. Sedikides, L. Gaertner, and Y. Toguchi (2003) reported findings favoring the universality of self-enhancement. S. J. Heine (2005) challenged the authors' research on evidential and logical grounds. In response, the authors carried out 2 meta-analytic investigations. The results backed the C. Sedikides et al. (2003) theory and findings. Both Westerners and Easterners self-enhanced tactically. Westerners self-enhanced on attributes relevant to the cultural ideal of individualism, whereas Easterners self-enhanced on attributes relevant to the cultural ideal of collectivism (in both cases, because of the personal importance of the ideal). Self-enhancement motivation is universal, although its manifestations are strategically sensitive to cultural context. The authors respond to other aspects of Heine's critique by discussing why researchers should empirically validate the comparison dimension (individualistic vs. collectivistic) and defending why the better-than-average effect is a valid measure of self-enhancement.     

The Group Home Workplace and the Work of Know-How

This paper is concerned with the everyday practice of authority and knowledge in a group home for adults with intellectual disability. Based on fieldwork, the group home is understood as a workplace, which provides a model of organizational participation as a dilemma of freedom rather than a problem of power. Three kinds of work are observed in the everyday know-how of counselors and residents. First, Michael Lipskys concept of street-level bureaucracy is used to understand the inherently indeterminate and conflictual nature of counselor work. Second, the competent participation of residents is also organized as work, often explicitly, as the work they must do to become more independent. The group home is therefore understood as a setting of governmentality because it reflects the indirect practice of authority characteristic of contemporary liberal societies. Finally, the ethnomethodological insight about the accomplished character of local order is the basis for the observation of everyday life itself as a third kind of work.     

Compelling untruths: content borrowing and vivid false memories

False memories are sometimes accompanied by surprisingly vivid experiential detail that makes them difficult to distinguish from actual memories. Such strikingly real false memories may be produced by a process called content borrowing in which details from presented items are errantly borrowed to corroborate the occurrence of the false memory item. In 2 experiments using think-out-loud protocols at both study and test, evidence for content borrowing occurred for more than half of the false remember judgments participants reported. The present study also provides evidence consistent with recollection rejection and distinctiveness playing a role in false-memory editing.     

Assessment of Reading and Learning Disabilities A Research-Based Intervention-Oriented Approach

Assessment practices for children with learning disabilities (LD) in reading are driven by the three primary components of the federal definition of LD: discrepancy, heterogeneity, and exclusion. This article reviews the implications of these three components for the assessment of children with reading disabilities and other forms of LD. We propose a rationale and procedures for more efficient approaches to the identification of children as learning disabled in reading or at-risk for these disabilities that are aligned with research on reading disabilities and other forms of LD. This approach emphasizes the assessment of academic skills and their components in an effort to develop intervention plans. Intelligence tests are not necessary for the identification of children as learning disabled and do not contribute to intervention planning.     

The "I," the "we," and the "when": a meta-analysis of motivational primacy in self-definition

What is the primary motivational basis of self-definition? The authors meta-analytically assessed 3 hypotheses: (a) The individual self is motivationally primary, (b) the collective self is motivationally primary, and (c) neither self is inherently primary; instead, motivational primacy depends on which self becomes accessible through contextual features. Results identified the individual self as the primary motivational basis of self-definition. People react more strongly to threat and enhancement of the individual than the collective self. Additionally, people more readily deny threatening information and more readily accept enhancing information when it pertains to the individual rather than the collective self, regardless of contextual influences. The individual self is the psychological home base, a stable system that can react flexibly to contextual influences.     

Spatial updating of locations specified by 3-d sound and spatial language

Blind and blindfolded sighted observers were presented with auditory stimuli specifying target locations. The stimulus was either sound from a loudspeaker or spatial language (e.g., "2 o'clock, 16 ft"). On each trial, an observer attempted to walk to the target location along a direct or indirect path. The ability to mentally keep track of the target location without concurrent perceptual information about it (spatial updating) was assessed in terms of the separation between the stopping points for the 2 paths. Updating performance was very nearly the same for the 2 modalities, indicating that once an internal representation of a location has been determined, subsequent updating performance is nearly independent of the modality used to specify the representation.     

Cerebrospinal fluid concentrations of biogenic amines and corticotropin-releasing factor in adolescent non-human primates as a function of the timing of adverse early rearing

Adolescent bonnet macaques nursed as infants by mothers facing unpredictable requirements for food procurement (variable foraging demand, VFD) display persistent neurobiological disturbances. This study examined the long-term neurochemical and behavioral effects of adverse rearing initiated later in infancy than in previous cohorts of subjects to test the hypothesis that the timing of an early adverse experience would influence patterns of biobehavioral outcome. Cisternal cerebrospinal fluid (CSF) monoamine and corticotropin-releasing factor (CRF) concentrations were obtained from 20 bonnet macaques (11 VFD-reared and 9 normally reared controls) approximately 2 years after the end of differential rearing. VFD-reared primates displayed on multiple samplings significantly lower CSF CRF concentrations and higher CSF 5-hydroxyindoleacetic acid (5-HIAA) concentration compared to controls. In the VFD-reared, significant inverse correlations between CRF and all three monoamines were found (5-HIAA, 3-methoxy-4-hydroxyphenethyleneglycol and homovanillic acid), most prominently for 5-HIAA. In controls, but not VFD-reared subjects, CSF CRF was positively correlated with changes in "gregariousness" upon presentation of a fear stimulus. VFD-reared subjects displayed greater baseline hierarchical engagement than controls. In contrast to prior findings, in which rearing under VFD conditions at an earlier age led to increased CSF CRF compared with controls, CSF CRF was lower after later exposure to VFD rearing than in controls. Thus, the timing of exposure to VFD conditions early in life evidently determines whether CSF CRF was found to be elevated or decreased, within the context of increased serotonin metabolism, during the course of primate maturation.