Phosphorylation of ERK/MAP kinase is required for long-term potentiation in anatomically restricted regions of the lateral amygdala in vivo

We have previously shown that the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/ MAPK) is transiently activated in anatomically restricted regions of the lateral amygdala (LA) following Pavlovian fear conditioning and that blockade of ERK/MAPK activation in the LA impairs both fear memory consolidation and long-term potentiation (LTP) in the amygdala, in vitro. The present experiments evaluated the role of the ERK/MAPK signaling cascade in LTP at thalamo-LA input synapses, in vivo. We first show that ERK/MAPK is transiently activated/phosphorylated in the LA at 5 min, but not 15 or 60 min, after high-frequency, but not low-frequency, stimulation of the auditory thalamus. ERK activation induced by LTP-inducing stimulation was anatomically restricted to the same regions of the LA previously shown to exhibit ERK regulation following fear conditioning. We next show that intra-LA infusion of U0126, an inhibitor of ERK/MAPK activation, impairs LTP at thalamo-LA input synapses. Collectively, results demonstrate that ERK/MAPK activation is necessary for synaptic plasticity in anatomically defined regions of the LA, in vivo.     

Meditation,mindfulness and cognitive flexibility

This study investigated the link between meditation, self-reported mindfulness and cognitive flexibility as well as other attentional functions. It compared a group of meditators experienced in mindfulness meditation with a meditation-naïve control group on measures of Stroop interference and the “d2-concentration and endurance test”. Overall the results suggest that attentional performance and cognitive flexibility are positively related to meditation practice and levels of mindfulness. Meditators performed significantly better than non-meditators on all measures of attention. Furthermore, self-reported mindfulness was higher in meditators than non-meditators and correlations with all attention measures were of moderate to high strength. This pattern of results suggests that mindfulness is intimately linked to improvements of attentional functions and cognitive flexibility. The relevance of these findings for mental balance and well-being are discussed.     

Business ethics and computer ethics: The view from Poland

An Aristotelian approach to understanding and teaching business ethics is presented and defended. The newly emerging field of computer ethics is also defined in an Aristotelian fashion, and an argument is made that this new field should be called “information ethics”. It is argued that values have their roots in the life and practices of a community; therefore, morality cannot be taught by training for a special way of reasoning. Transmission of values and norms occurs through socialization — the process by which an individual absorbs not only values but also the whole way of life of his or her community. It follows that business ethics and information ethics can be considered kinds of socialization into a profession: role learning and acquiring a new self-identification. This way of understanding fields of applied ethics is especially important for their proper development in Central-Eastern Europe because of endemic factors which are the result of recent political developments there.     

Evaluation of drug toxicity in clinical trials

An increasing number of drugs removed from the market because of unacceptable toxicity raises concerns regarding preapproval testing of drug safety. In the present paper it is postulated that the non-inferiority type of trial should be abandoned in favor of the superiority trial with active controls and less stringent (p<0.1, both for efficacy and toxicity) statistics. This approach will increase sensitivity of detection of drug-induced adverse effects at the expense of increasing false positive results regarding the difference in efficacy between the tested and reference drug. Such a move will increase the protection of future patients. In addition, the proposed design is far more acceptable from the clinical (e.g. no need to specify the statistically expected “unimportant” number of deaths) and ethical points of view, as well as being favored by the strong incentive of involved parties. In the second part of this paper arguments are presented in favor of the hypothesis that placebo (still used in some superiority trials) does not induce adverse effects. The assertion that placebo may induce adverse effects is probably biased by the nature of the clinical experiment. Such a conclusion is supported by studies indicating that placebo-induced adverse effects are disease — and treatment — specific. The modification of clinical trials according to the proposed changes may increase the trials’ sensitivity at detecting adverse effects of drugs. A lecture on the subject of this paper was presented at the 6th International Bioethics Conference on the subject of ‘The Responsible Conduct of Basic and Clinical Research’, held in Warsaw, Poland, 3–4 June 2005.     

On the degree of complexity of sentential logics. A couple of examples

The first part of the paper is a reminder of fundamental results connected with the adequacy problem for sentential logics with respect to matrix semantics. One of the main notions associated with the problem, namely that of the degree of complexity of a sentential logic, is elucidated by a couple of examples in the second part of the paper. E.g., it is shown that the minimal logic of Johansson and some of its extensions have degree of complexity 2. This is the first example of an exact estimation of the degree of natural complex logics, i.e. logics whose deducibility relation cannot be represented by a single matrix. The remaining examples of complex logics are more artificial, having been constructed for the purpose of checking some theoretical possibilities.The paper was presented to the Polish Philosophical Society, Wrocaw Branch, at its meeting on March 27^th, 1980.The authors wish to thank both the referees of Studia Logica for their helpful and very insightful remarks. Following their criticism, we have been able to improve the style and structure of our presentation. In particular, we are indebted to the referees for pointing out a gap in the original proof of Theorem 2, and we have incorporated into the revised text a corrected proof of step (2.1) which one of them was kind enough to supply in detail.     

Degrees of maximality of Klukasiewicz-like sentential calculi

The paper is concerned with the problem of characterization of strengthenings of the so-called Lukasiewicz-like sentential calculi. The calculi under consideration are determined byn-valued Lukasiewicz matrices (n>2,n finite) with superdesignated logical values. In general. Lukasiewicz-like sentential calculi are not implicative in the sense of [7]. Despite of this fact, in our considerations we use matrices analogous toS-algebras of Rasiowa. The main result of the paper says that the degree of maximality of anyn-valued Lukasiewicz-like sentential calculus is finite and equal to the degree of maximality of the correspondingn-valued Lukasiewicz calculus. Allatum est die 15 Octobris 1976     

On the degree of complexity of sentential logics.II. An example of the logic with semi-negation

In this paper being a sequel to our [1] the logic with semi-negation is chosen as an example to elucidate some basic notions of the semantics for sentential calculi. E.g., there are shown some links between the Post number and the degree of complexity of a sentential logic, and it is proved that the degree of complexity of the sentential logic with semi-negation is 20. This is the first known example of a logic with such a degree of complexity. The results of the final part of the paper cast a new light on the scope of the Kripke-style semantics in comparison to the matrix semantics.In memory of Roman Suszko