环境雌激素双酚A对成年小鼠学习记忆和突触结构的影响*

双酚A (bisphenol, BPA)是一种广泛存在的环境内分泌干扰物,它可与雌激素受体结合干扰内源性雌激素对中枢神经系统的调控作用。本研究通过将10周龄小鼠灌胃染毒BPA (0.4、4、40 mg/kg/day)3个月,研究长期BPA暴露对成年小鼠记忆行为和突触可塑性的影响。开场行为测试结果表明, BPA (0.4、4、40 mg/kg/day)增加雄性的站立次数和理毛频率, BPA (4 mg/kg/day)却显著减少雌鼠的站立次数。水迷宫和被动回避行为模型检测显示, BPA主要损伤雄鼠的空间学习记忆和被动回避记忆。通过制备海马CA1区超薄切片后,电镜观测发现, BPA (0.4、40 mg/kg/day)暴露降低雄鼠海马CA1区突触数密度,缩短雄鼠突触前活性带长度,减小雄鼠突触后致密体(PSD)厚度,增加雄鼠突触间隙宽度。进一步用Western blot方法检测突触前、后的标志性蛋白Synapsin I和PSD95以及兴奋性氨基酸NMDA受体NR1亚基和AMPA受体GluR1亚基蛋白的表达,发现BPA暴露致雄鼠Synapsin I、PSD95、NR1蛋白表达水平下调。而BPA对雌鼠的记忆行为、突触形态、突触蛋白和受体蛋白均没有明显作用。以上结果提示长期B PA暴露性别特异性地影响成年小鼠的活动性和探究行为,损伤雄鼠的学习记忆,这些作用可能通过下调突触蛋白和NMDA受体的表达而负性影响突触结构可塑性,最终影响雄鼠的学习记忆功能。     

跨文化判断与决策(英文)

本文对判断和决策研究领域所发现的跨文化差异进行了回顾。鉴于大多数判断和决策的跨文化研究都集中于对亚洲和西方文化的比较,本文也主要关注这方面的研究发现。具体来说,本文回顾了在概率判断及信心、风险知觉、冒险行为、消费者行为以及经济判断和决策中所存在的跨文化差异。综述结果表明尽管亚洲人和西方人的判断和决策行为存在很大的跨文化差异,研究也发现了显著的文化内差异。目前关于判断和决策的跨文化差异的研究还相对匮乏,未来还需要更多的研究来进一步了解判断和决策行为的跨文化差别及机制。     

试论高校隐性德育课程设计

高校学生工作即德育工作,虽高等教育质量的生命线,这对于培养新世纪高素质人才具有十分重要的现实意义。高校德育主要是通过德育课程来完成的。高校德育课程由显性德育课程与隐性德育课程两部分构成。实施高校隐性德育课程设计必须深刻理解其内涵及特征,客观确定其价值取向,科学设计其课程内容。     

Social Contagion and Multiplexity Communication Networks as Predictors of Commitment and Role Ambiguity

This research compares two contrasting perspectives of social contagion processes associated with the organizational outcome variables of commitment and role ambiguity in organizations. The two perspectives are structural equivalence (which focuses on the positions of individuals in social networks) and cohesion (which focuses on an individual's direct communication contacts). It was hypothesized that structural equivalence would be more associated with role ambiguity and that commitment would be more associated with cohesion. The relationship between these variables and multiplex content networks was also studied. It was hypothesized that commitment was a much more broadly based concept in the sense that a number of functional content networks systematically relate to it. On the other hand, role ambiguity was hypothesized to be more closely associated with uniplex networks, especially those related to job duties and organizational goals. While there were exceptions, generally the research results supported the hypotheses relating to multiplexity. The hypotheses that structural equivalence was more associated with role ambiguity and that commitment was more associated with cohesion also were supported in this research.     

VALIDITY AND TEST-RETEST STABILITY OF THE NASH MANAGERIAL EFFECTIVENESS SCALE ON THE REVISED FORM OF THE STRONG VOCATIONAL INTEREST BLANK1

Managers ’motives (preferences for different activities or outcomes) probably determine, in part, their relative job effectiveness. This hypothesis was tested and confirmed by Nash (1966) when he developed and cross-validated a Managerial Effectiveness Key for the 1937 edition of the Strong Vocational Interest Blank (SVIB). We revised the Nash SVIB key for those items retained in the recently-revised form of SVIB (Campbell, 1966). The new key has the same validity as Nash's key and high test-retest stability for lengthy periods of time (up to twenty-two years). Validity of the key is not extremely high (about .30), but its content does denote a pattern of stable and distinct manager motives which merit study along with cognitive, aptitude, and temperament factors as potential determiners of effective managing.     

疼痛恐惧对疼痛的影响及其认知机制

疼痛恐惧是把将要出现的疼痛刺激视为主要威胁而产生的一种恐惧,它会影响与疼痛相关的感知觉、注意、回避行为以及安慰剂止痛的效果.疼痛恐惧的认知模型主要有活动回避模型、恐惧-回避模型以及内感受性恐惧条件模型.未来的研究要进一步探究疼痛恐惧的认知机制,完善疼痛恐惧的认知模型并扩展疼痛恐惧的研究方法.     

母亲抑郁对青少年抑郁的影响:亲子关系的中介作用与青少年消极情绪性的调节作用

对1708名八年级青少年（平均年龄14.30±0.48岁,男生852名）及其母亲（平均年龄39.17±2.47岁）的抑郁症状、母子关系和青少年消极情绪性进行测量,考察了母亲抑郁对青少年抑郁的影响机制。结果发现：（1）母亲抑郁能够正向预测青少年的抑郁;（2）母子关系在母亲抑郁与青少年抑郁之间起中介作用,母亲抑郁既能增加母子冲突的强度,也能降低母子亲合水平,进而导致青少年的抑郁;（3）青少年消极情绪性在母亲抑郁影响青少年抑郁的中介机制中起调节作用,仅在高消极情绪性的青少年中,母子冲突能够显著预测青少年的抑郁;但消极情绪性不能调节母子亲合对青少年抑郁的影响;（4）母亲抑郁影响青少年抑郁的有调节的中介模型不存在性别差异。     

从不同高血压防治指南的比较看高血压治疗策略的变化

为减少因高血压造成的各种心血管事件,世界不同地区制定或修订了适合自己的高血压防治指南.通过对JNC7、ESH/ESC及2004年中国高血压防治指南的比较及分析,以便能更全面、正确地理解和发展我国新的高血压指南,并将该指南灵活运用于实际工作.     

从循证医学看目前冠心病的药物治疗

为使冠心病患者尽可能达到最优化的药物治疗,结合最近几年出现的大型临床研究,分析了不同冠心病患者应采取的合理药物治疗措施及可能带来的益处,并针对我国现状,提出了相应的解决方案.