Vagueness as closeness

This paper presents and defends a definition of vagueness, compares it favourably with alternative definitions, and draws out some consequences of accepting this definition for the project of offering a substantive theory of vagueness. The definition is roughly this: a predicate ‘F’ is vague just in case for any objects a and b, if a and b are very close in respects relevant to the possession of F, then ‘Fa’ and ‘Fb’ are very close in respect of truth. The definition is extended to cover vagueness of many-place predicates, of properties and relations, and of objects. Some of the most important advantages of the definition are that it captures the intuitions which motivate the thought that vague predicates are tolerant, without leading to contradiction, and that it yields a clear understanding of the relationships between higher-order vagueness, sorites susceptibility, blurred boundaries, and borderline cases. The most notable consequence of the definition is that the correct theory of vagueness must countenance degrees of truth.     

Differential effects of post-training muscimol and AP5 infusions into different regions of the cingulate cortex on retention for inhibitory avoidance in rats.

Adult male Wistar rats were bilaterally implanted with indwelling cannulae in four different coordinates of the cingulate cortex: (1) the anterior cingulate (AC), (2) the rostral region of the posterior cingulate (RC), (3) the upper portion of the caudal region of the posterior cingulate (UC), and (4) the lower portion of the caudal region of the posterior cingulate (LC). After recovery, animals were trained in a step-down inhibitory avoidance task (3.0-s, 0.4-mA foot shock). Either immediately, or 90 or 180 min after training, animals received a 0.5-microl infusion of vehicle (phosphate buffer, pH 7.4), of muscimol (0.5 microg), or of AP5 (5.0 microg). Retention testing was carried out 24 h after training. Muscimol was amnestic when given into any of the three coordinates of the posterior cingulate cortex 90 min after training, and when given into LC immediately post-training. In addition, AP5 was amnestic when given into UC 90 min post-training, but not when given into any other region and/or at any other time. None of the treatments had any effect when given into AC. The results suggest that memory processing of the inhibitory avoidance task is regulated by the posterior but not by the anterior cingulate cortex, through muscimol-sensitive synapses, relatively late after training. AP5-sensitive synapses appear to play a very limited role in these processes, restricted to UC.     

Time-dependent modulation of inhibitory avoidance memory by spermidine in rats

The polyamines, spermine, spermidine, and putrescine, are a group of aliphatic amines that may act as physiological modulators of N-methyl-D-aspartate (NMDA) receptors. Although the modulatory role of polyamines in NMDA receptor function has long been known, the effects of polyamines on learning and memory only recently began to be unraveled. In the present study, we investigated the effect of bilateral infusions of spermidine (0.02-2 nmol), a polyamine agonist, into the CA1 region of the rat dorsal hippocampus on inhibitory avoidance learning 30 min pre-training, immediately post-training, 6 h post-training, or 10 min pre-test. Bilateral microinjections of 0.2 nmol spermidine prolonged step-down latencies compared to the respective control group when administered 30 min pre-training or immediately post-training. These results provide evidence that the modulatory effects of spermidine on the acquisition and/or early consolidation of memory of inhibitory avoidance tasks in the hippocampus occur within a limited time window.     

The attractiveness-positivity link: Let’s contextualize it

The statement “what is beautiful is good” reflects a persuasive heuristic that may be supported either by a general association of attractiveness with positivity or by a specific association with the perceived credibility of an attractive source. In one study (N = 58), we approach this question using an explicit and an implicit measure (Stroop Task) to assess whether attractiveness is more likely associated with valenced words when these are related (vs. unrelated) to credibility. Results show that this effect occurs but only for the implicit measure. When the word-face associations were made at an explicit level, we found a general association between positivity and attractiveness, unrestricted to the dimension of credibility. We discuss how these results inform about attractiveness as a shortcut to judgments of validity.     

Combining total laparoscopic hysterectomy and bilateral salpingo-oophorectomy with subcutaneous mastectomy in trans men: The effect on safety outcomes

Abstract

Background: Masculinizing mastectomy is the most requested gender affirming surgery (GAS) in trans men, followed by genital GAS. Mastectomy and total laparoscopic hysterectomy, with or without bilateral salpingo-oophorectomy (TLH?±?BSO), can both be performed in one single operation session. However, data on complication rates of the combined procedure is scarce and no consensus exists on the preferred order of procedures.

Aims: To compare safety outcomes between mastectomy performed in a single procedure with those when performed in a combined procedure and assess whether the order of procedures matters when they are combined.

Methods: A retrospective chart review was performed of trans men who underwent masculinizing mastectomy with or without TLH?±?BSO in a combined session. The effects of the surgical procedure on complication and reoperation rate of the chest were assessed using logistic regression.

Results: In total, 480 trans men were included in the study. Of these, 212 patients underwent the combined procedure. The gynecological procedure was performed first in 152 (71.7%) patients. In the total sample, postoperative hematoma of the chest occurred in 11.3%; 16% in the combined versus 7.5% in the single mastectomy group (p?=?0.001). Reoperations due to hematoma of the chest were performed in 7.5% of all patients; 10.8% in the combined versus 4.9% in the single mastectomy group (p?=?0.017). The order of procedures in the combined group had no significant effect on postoperative hematoma of the chest (p?=?0.856), and reoperations (p?=?0.689).

Conclusion: Combining masculinizing mastectomy with TLH?±?BSO in one session was associated with significantly more hematoma and reoperations compared with separately performing mastectomy. This increased risk of complications after a combined procedure should be considered when deciding on surgical options. The order of procedures in a combined procedure did not have an effect on safety outcomes.     

THE PAST,PRESENT, AND FUTURE ALL MATTER: HOW TIME PERSPECTIVE IS ASSOCIATED WITH OPTIMISM AND SENSATION SEEKING AMONG YOUNG ADULTS

We used a multidimensional model of time perspective to examine how feelings and thoughts about the past, present, and future were related to optimism and sensation seeking among young adults. The dimensions of time perspective assessed were time feelings, the positive and negative emotions one has about the past, present, and future; time frequency, the amount of thinking about each time period; and time orientation, the relative emphases toward the time periods. Optimism and sensation seeking were self-reported and participants included 463 young adults. Variable-based analyses indicated that reporting more positive and less negative feelings about the time periods or emphasizing the present and future simultaneously were associated with greater optimism. For sensation seeking, boredom susceptibility was especially associated with the time perspective dimensions. Person-centered analyses based on time feelings and time frequency yielded four profiles (i.e., Mindful, Discontent, Bleak, and Indifferent) that were associated with both optimism and sensation seeking.     

A CONSTRUCT MATURES: TIME PERSPECTIVE’S MULTIDIMENSIONAL,DEVELOPMENTAL, AND MODIFIABLE QUALITIES

Human development approaches to time perspective that are life-span and include multiple developmental periods are largely lacking in the literature even though the topic has received wide attention from many scholars. Extant studies have focused on specific age groups or have compared younger and older adults. This introduction addresses these issues and provides on overview of the multidimensional, developmental, and modifiable qualities of time perspective. The four contributions focus on distinct age groups including adolescents, young adults, middle-aged adults, and older adults. The papers comprised several conceptualizations of time perspective, diverse participants, and age-specific outcomes. Collectively, this work sets the stage for the next era of age-related research on time perspective.