现代科学技术对大肠癌微转移诊断的推进作用及启示

大肠癌是最常见的恶性肿瘤之一,转移和复发依然是影响大肠癌患者预后的重要因素,肿瘤细胞在血液、骨髓及淋巴结中的微转移是肿瘤转移和复发的基础;随着现代科学技术的发展,出现了通过逆转录聚合酶链式反应(RT-PCR)来检测细胞角蛋白20(CK20)mRNA的表达,从而诊断大肠癌微转移的高度敏感与特异的方法,并引发了关于如何看待事物、认识事物及如何科学思维的几点思考.     

科学是中医的“紧箍咒”吗？——中医与科学相关问题的思考

中医的科学属性近年来备受争论,从辩证哲学、科学观念、中医的人文哲学特色等角度剖析中医的哲学内涵和科学隶属,澄清观念,得出结论,中医本身就是一门人文与科学交融的古代科学,传统文化与现代科技的互融互动,合而不同,新世纪发展中医的认识观需要与时俱进。     

中国传统的音乐治疗研究

音乐是人心理活动的产物,同时音乐还具有一定的治疗作用。音乐疗法是集心理学、医学、生理学、哲学、音乐、艺术于一体的综合性的新兴学科,作为一门应用科学,逐渐被社会所接受,并日趋成熟。中国有丰富的音乐治疗的思想。特别是五音疗法,反映了传统的“天人合一”思想。五音疗法整合了人与自然、社会的相互作用和影响;体现了对音乐与情绪及脏腑之间的互动关系;突现了音声与人格情志、脏气等的关系。五音疗法匹配了人体的不同脏腑,把五音、五行、五脏、人格配属用于音乐治疗实践。     

The malleability of executive function in early childhood: Effects of schooling and targeted training

Executive function (EF), its importance for scholastic achievement and the question of whether or not EF is malleable, have become a topic of intense interest. Education or schooling is often seen as effective approaches to enhance EF due to the specific school‐related requirements as compared to kindergarten or pre‐school. However, no study to date has investigated whether targeted training focusing on those domains might be comparable with regular schooling in improving EF and fluid intelligence (Gf). The aim of the present study was to replicate and extend the previously demonstrated schooling effects on EF by using a school‐cutoff design, and to further investigate whether a theoretically motivated intervention targeting specific EF, i.e., working memory (WM) or inhibitory control (IC), could achieve comparable effects with schooling in both, WM and IC, as well as Gf. 91 6‐year‐old kindergarteners and first‐graders with similar chronological age participated the study. We compared the performance of a first‐grade schooling group with that of two kindergarten training groups as well as a business‐as‐usual kindergarten control group. Participants were assessed in WM, IC and Gf at baseline, immediately after the intervention (posttest), as well as 3 months after training completion (follow‐up). The results showed that the schooling group indeed outperformed the kindergarten groups at baseline in several cognitive tasks. Furthermore, both the WM and IC training showed pronounced gains in the trained tasks, as well as varying degrees of improvement in non‐trained outcome measures. Most importantly, both training groups achieved comparable performance with the schooling group, which was especially apparent in Gf at follow‐up. Our findings provide further evidence for the malleability of EF demonstrating that both, long‐term and short‐term interventions can facilitate the acquisition of those important skills, and as such, our work has important implications for educational practice.     

9～11岁儿童形式运思能力发展的ERP研究

关于儿童认知发展的静息电位研究支持儿童发展的连续性与阶段性的统一,但诱发电位研究没能提供类似的证据,可能因为以往研究采用的oddball任务不够敏感.本研究通过改编形式运思任务来继续深入探讨儿童认知发展与大脑发育的关系.31名儿童(9岁组11人.10岁组10人,11岁组10人)完成形式运思任务,并同时记录脑电.结果发现:随着年龄增长,反应时逐渐缩短,正确率逐渐增高;三组儿童中,10岁组N380波幅最低,10岁组350-400毫秒的电位图较其他两组更为弥散.     

冲动性消费行为内在机制研究述评 ———提升调节点在冲动性消费行为中所起作用

有关冲动性消费行为研究的文献众多,但难以从内在联系上进行统一。最近,利用提升调节点对冲动性消费行为内在机制的揭示是该领域的一个突破,从而有望把一些相关文献统一起来。作者介绍了冲动性消费行为内在过程;综述了用于冲动性消费行为内在机制研究的相关理论;从内在机制这个角度对有关冲动性消费行为文献进行评述。文章的最后提出了冲动性消费行为内在机制的进一步研究方向：利用调节点等相关理论,特别是调节适应理论对冲动性消费行为内在机制做进一步探讨     

阻断内侧前额叶皮质TrkB受体对大鼠认知和海马BDNF表达的影响

脑源性神经营养因子(brain-derived neurotrophic factor, BDNF)广泛参与了个体学习和记忆等认知功能, 通过与其酪氨酸激酶受体(tyrosine kinase, TrkB)特异性结合, 实现其多种神经生化功能。本研究观察了TrkB受体阻断剂ANA-12的慢性内侧前额叶皮质(medial prefrontal cortex, mPFC)注射对大鼠旷场行为、Morris水迷宫空间学习和逆反学习的影响。研究结果表明, mPFC的慢性BDNF阻断显著降低了大鼠在逆反学习测试中的逃离潜伏期和运动距离即增强了大鼠的逆反学习能力, 但不影响其旷场行为和水迷宫空间学习能力。同时, 慢性阻断mPFC-TrkB受体也并未导致大鼠海马BDNF蛋白含量的显著改变。这些结果提示, 对于大鼠的Morris水迷宫空间学习和逆反学习, mPFC-BDNF主要在逆反学习调节中发挥重要作用。这对于进一步探索海马和mPFC在调节个体认知功能中各自的作用及其潜在的相互关系提供了有力的证据和支持。     

享乐适应理论的发展及应用

随着全民关注幸福的时代到来, 享乐适应理论作为研究幸福的钥匙, 引起了多学科的广泛关注。文章首先从享乐适应的内涵、与幸福感的关系、发生机制、减缓方式出发进行文献梳理与评述, 接着重点探讨享乐适应理论在消费行为学、经济学、组织行为学等领域的应用研究, 以期为个体提升幸福感及企业通过提升消费者与员工的幸福感来强化他们对企业的正面认知提供帮助。未来应不断扩展享乐适应理论的应用范围, 重点关注各领域中变动的主体及形式对享乐适应的影响。     

低地位群体的外群体偏好

内群体偏好是群际关系中较为普遍现象。但是, 近来研究发现, 在低地位群体中存在着外群体偏好现象。社会认同理论、社会优势理论和系统公正理论从不同角度对这一现象进行了解释。社会认同理论关注情境因素的作用, 它描述了在何种情境下, 外群体偏好可能会出现。社会优势理论认为, 低地位群体成员的社会优势取向水平会决定其究竟是反抗现状还是接受现状。系统公正理论提出, 系统公正动机会使低地位群体成员支持与其内群体利益相违背的现存等级系统。每个理论各有优劣之处, 将各理论进行整合是值得考虑的研究方向。本文提出, 在解释低地位群体的外群体偏好现象时, 社会认同与社会优势取向之间可能会存在交互作用。     

What Does It Mean to Be an American? Patriotism,Nationalism, and American Identity After 9/11

The period of heightened nationalism in the United States that followed the terrorist attacks of 11 September 2001 provided unusual conditions for investigating issues surrounding the distinction between patriotism and nationalism and the relationship between national identification and pluralistic values. In a survey of national identity and social attitudes conducted in late September 2001, two different definitions of national unity were inserted in the introduction to the questionnaire in an attempt to prime activation of different conceptualizations of nationality. Results demonstrated that the priming conditions did have an effect on the pattern of interrelationships among measures of patriotism, nationalism, and tolerance for cultural diversity.