黑色素瘤内科治疗的新进展

黑色素瘤的生物学知识在对这种疾病的药物研发上发挥了重要的作用。在过去的10年中,黑色素瘤进入了靶向治疗的新时代,这种疾病的治疗方法发生了革命性的改变。从2011年,已有4种新药被批准应用于转移性黑色素瘤的治疗,包括：伊匹单抗、维罗菲尼、达拉菲尼和曲美替尼。目前几种新药正处于3期临床试验阶段,以期更多的药物被批准用于这种...     

幼儿父母婚姻冲突与教养方式的关系:父母情绪调节策略的调节作用

以285名幼儿家长为被试,采用问卷法考察婚姻冲突对权威教养和专制教养的差别效应以及父母情绪调节策略在其中的调节作用。结果发现:(1)幼儿父母的婚姻冲突能显著负向预测其权威教养,显著正向预测其专制教养,婚姻冲突对两类教养的预测作用大小无显著差异;(2)父母情绪调节策略对婚姻冲突与权威教养关系的调节作用显著,且这种调节作用不存在家长性别的差异:较少使用认知重评或较多使用表达抑制的家长,其婚姻冲突能显著负向预测权威教养;经常使用认知重评或较少使用表达抑制的家长,其婚姻冲突对权威教养的影响不显著。父母情绪调节策略对婚姻冲突与专制教养关系的调节作用不显著。     

Bayesian analysis of mixtures in structural equation models with non‐ignorable missing data

Structural equation models (SEMs) have become widely used to determine the interrelationships between latent and observed variables in social, psychological, and behavioural sciences. As heterogeneous data are very common in practical research in these fields, the analysis of mixture models has received a lot of attention in the literature. An important issue in the analysis of mixture SEMs is the presence of missing data, in particular of data missing with a non‐ignorable mechanism. However, only a limited amount of work has been done in analysing mixture SEMs with non‐ignorable missing data. The main objective of this paper is to develop a Bayesian approach for analysing mixture SEMs with an unknown number of components and non‐ignorable missing data. A simulation study shows that Bayesian estimates obtained by the proposed Markov chain Monte Carlo methods are accurate and the Bayes factor computed via a path sampling procedure is useful for identifying the correct number of components, selecting an appropriate missingness mechanism, and investigating various effects of latent variables in the mixture SEMs. A real data set on a study of job satisfaction is used to demonstrate the methodology.     

心力衰竭国内外指南浅析

近几年随着循证医学证据的不断增加,各国对心力衰竭指南进行了更新.主要是2012年欧洲心脏病学会(ESC)与心衰学会公布的心力衰竭新指南、2011年澳大利亚和新西兰慢性心力衰竭诊治指南、2010年英国国立健康与临床优化研究所(NICE)慢性心力衰竭诊治指南、2009美国心脏病学会(ACC)/美国心脏协会(AHA)实践指南工作组成人心力衰竭诊疗指南及2010年我国的急性心力衰竭指南等.各国指南对心力衰竭的诊断和治疗都提出了具体的意见和建议,其中不乏亮点,如对慢性心力衰竭患者更加重视血运重建的治疗作用、推荐心力衰竭治疗的一种新型β受体阻滞剂奈必洛尔等等.我们对以上几个指南做了浅要分析,以取长补短更规范的诊治心力衰竭患者.     

国外护理硕士教育与临床实践效果的研究现状

通过文献分析法,一方面探讨美国、英国、日本、泰国护理硕士研究生的招收条件、培养目标与课程设置、综合评定考核方法等,了解国外护理硕士培养机制;另一方面分析国外护理硕士课程对临床护理的影响,以及毕业后从事临床护理的实践效果和临床工作中面临的挑战,以期为我国护理硕士教育的发展提供借鉴.     

腹腔镜在女性盆底修复术中的应用

随着社会老龄化的加剧,盆底功能障碍性疾病的发病率日益上升.之前热门的盆底重建术随着时间的推移,并发症相继出现.美国食品药品管理局(FDA)连续两次发布了关于经阴道网片的警告,使专家们认识到了问题的严重性.经过30余年的发展,腹腔镜技术已经被广泛地应用于各类妇科手术中.腹腔镜在女性盆底修复术中的应用重新得到了关注.自1991年腹腔镜技术首次应用于女性盆底修复手术中以来,国内外不断有新的腹腔镜下盆底修复术式的报道.现就各种腹腔镜下盆底修复手术做一综述.     

海峡两岸大学生生命意义比较研究——以广州市与台中市为例

该研究以广州市与台中市大学生为被试,抽取500人为预测样本及800人为正式施测样本,通过探索性因素分析和验证性因素分析编制生命意义量表,并通过t检验和潜在剖面分析考察两岸大学生生命意义现况的差异.结果表明：（1）编制的生命意义量表由存在意义、追寻意义、存在盈实、苦难接纳、死亡接纳以及求意义的意志等6个维度组成,具有良好的信度和效度.（2）两岸大学生生命意义总体无显著差异;存在盈实、苦难接受与死亡接纳维度有显著或非常显著的差异.（3）潜在剖面分析结果显示,两岸大学生生命意义类型相似.Wald检验结果表明,对于“死亡接纳”维度,台湾与大陆学生在各潜在类别的均分上存在显著的差异.     

Intuitive Conceptions of Dead Persons' Mentality: A Cross-Cultural Replication and More

Jesse Bering (2002) investigated how American university students in an interview task conceived of dead persons' mentality immediately after death. He found that different categories of mental states or capacities were conceived differently: psychobiological and perceptual states ceased, whereas emotional, desire, and epistemic states continued. Our Study 1 was a replication of Bering's experiment in a different cultural setting, in which the subjects were Chinese undergraduate students. A similar pattern of results was found. In Study 2, instead of being asked about a dead person's various mental states immediately following the death, participants were asked to judge a dead person's mental states after the person had been dead for 2 days. The overall pattern of participants' responses was not affected by this manipulation, but they did show an increase in attributions of certain mental states to dead agnostics. In addition, a more refined breakdown of responses revealed that individuals tended to judge that, upon death, visual and auditory perception continued, whereas olfactory and gustatory sensation ceased.     

The development of social value orientation across different contexts

This study aimed to explore Chinese children's social value orientation across different ages and contexts. Revised decomposed games were used to measure the social value orientation of 9‐, 11‐, and 14‐year‐old children and college students as an adult group. About half of them were assigned to the hypothetical context of “equal payment group,” providing equal compensation for participation in the study, and the others to the “real payment group,” who got payment according to their own choices in the games. Results showed that 9‐ and 11‐year‐old children's choices differed between the two contexts: They made more prosocial choices in the hypothetical context, and more competitive choices in the “real payment” context. The 14‐year‐olds’ and adults’ choices were not significantly different in the two contexts. These results may imply that by 14 years of age, children have stable social value orientation, and their behavior reflects this value.