A simple histological technique for localizing electrode tracks and lesions within the brain.

Histological procedures are necessary in brain stimulation or lesion work to determine the neural area which has been stimulated or damaged. Preparation of brain tissue often involves embedding and staining techniques that require specialized training, and the expense of a technician and a large assortment of special apparatus and supplies. In addition, the results of such techniques are unavailable for at least several days. A photographic method, which requires little special skill and a minimal amount of apparatus, is described here. Results can be available within minutes after the subject is sacrificed. This method has been shown to be adequate for the gross determination of lesion boundaries and electrode or cannula tip loci in brains of rats, cats, and squirrel monkeys.     

A comparison of four methods of constructing factor scores

Four least-squares methods for constructing factor scores have been described in the literature. The formal properties of these scores are developed, and they are compared in terms of four generally desirable properties of constructed factor scores. In particular, it is shown that two of the methods yield scores that are conditionally unbiassed, and univocal in the sense of Guilford and Michael, though not orthogonal, while one of the other methods yields orthogonal scores.It is shown that constructed factor scores cannot be simultaneously univocal and orthogonal, unless we choose the special basis in factor space given by Canonical Factor Analysis.The general problem of choosing between the methods is discussed, on the basis of the theoretical relations obtained.EDITOR'S NOTE: The reader will quickly discover that this article develops several of the generalizations given in the second part of the preceding article, On Factors and Factor Scores. Independent development of the same generalizations is, of course, not a new phenomenon. Because the Presidential Address automatically is accepted for publication and given space in the December issue, it was decided that the only fair thing to do was to print this article in the same issue.