Providers’ Perceptions and Practices Regarding <Emphasis Type="BoldItalic">BRCA1/2</Emphasis> Genetic Counseling and Testing in African American Women

We examined healthcare providers’ perceptions of genetic counseling and testing in African American women at moderate to high-risk of carrying a BRCA1/2 mutation. We conducted 20 in-depth interviews with genetic counselors (n = 5), medical oncologists (n = 8), obstetrician/gynecologists (n = 2) and surgeons (n = 5). Interviews were audiotaped, transcribed and independently coded by two individuals using a content analysis approach. Seven themes emerged relevant to providers’ perceptions of African American women’s use of BRCA1/2 genetic services: access factors, cultural beliefs and preferences, effects of testing, patient motivators for genetic counseling and testing, patient-provider communication, reasons for provider referral, and reasons for patient refusal. Providers identified individual- and system-level barriers to African American women’s use of genetic services, including lack of follow-up after referrals to genetic specialists and challenges to obtaining financial coverage for under- and uninsured high-risk women. Results have implications for physician and patient education regarding appropriate referrals to and uptake of genetic services in at-risk African American women.     

Evaluating risk propensity using an objective instrument

Risk propensity is the stable tendency to choose options with a lower probability of success, but greater rewards. Its evaluation has been approached from various perspectives: from self-report questionnaires to objective tests. Self-report questionnaires have often been criticized due to interference from voluntary and involuntary biases, in addition to their lack of predictive value. Objective tests, on the other hand, require resources that make them difficult to administer to large samples. This paper presents an easy-to-administer, 30-item risk propensity test. Each item is itself an objective test describing a hypothetical situation in which the subject must choose between three options, each with a different gain function but equivalent in expected value. To assess its psychometric fit, the questionnaire was administered to 222 subjects, and we performed a test of its reliability as well as exploratory factor analysis. The results supported a three-factor model of risk (Sports and Gambling, Long-term Plans, and Loss Management). After making the necessary adjustments and incorporating a global factor of risk propensity, confirmatory factor analysis was done, revealing that the data exhibited adequate goodness of fit.     

The interplay of spatial attention and memory: evidence for memory-driven spatial compatibility effects, but not for a facilitating role of attention in memory retrieval

The visual indexing theory proposed by Zenon Pylyshyn (Cognition, 32, 65-97, 1989) predicts that visual attention mechanisms are employed when mental images are projected onto a visual scene. Recent eye-tracking studies have supported this hypothesis by showing that people tend to look at empty places where requested information has been previously presented. However, it has remained unclear to what extent this behavior is related to memory performance. The aim of the present study was to explore whether the manipulation of spatial attention can facilitate memory retrieval. In two experiments, participants were asked first to memorize a set of four objects and then to determine whether a probe word referred to any of the objects. The results of both experiments indicate that memory accuracy is not affected by the current focus of attention and that all the effects of directing attention to specific locations on response times can be explained in terms of stimulus-stimulus and stimulus-response spatial compatibility.     

Reliability and acceptability of web-based administration of Spanish ages and stages questionnaires third edition®

to analyse the reliability of 6 age intervals of Spanish web-based Ages and Stages Questionnaires Third Edition (WB-ASQ-3) and parents' acceptability, in a clinical practice context, during COVID-19 pandemic and lockdown in Chile. Cross-sectional study with a longitudinal component. Internal consistency was analysed by Cronbach's alpha and Pearson product–moment correlation, Pearson's correlations between intervals questionnaires were analysed. Acceptability was determined using a parental satisfaction survey. 1061 children completed 2318 validated questionnaires. Scores were compared with normative sample, except for Gross motor at 8 and 12 months, and Communication at 12, 18 and 24 months, without differences to the previous Chileans sample. In domain analysis, Cronbach's alpha ranged from 0.36 to 0.80 and reached 0.74 to 0.81 for the overall test. Strong positive correlation between the domain and overall score was obtained. Correlation between most questionnaires at different ages was positive and significant. Parental surveys show high satisfaction; parents were thankful for being able to monitor children's development. WB-ASQ-3 is a reliable and feasible screening system, particularly when the test is taken as a whole, rather than by domains. It is remarkably high acceptability among parents, especially in complex times such as the lockdown and the COVID-19 pandemic.     

Serotonin transporter (5-HTTLPR) genotype, childhood abuse, and suicide attempts in adult psychiatric inpatients

There is growing evidence that a functional polymorphism in the serotonin transporter gene (5-HTTLPR) moderates the impact of negative life events (e.g., childhood abuse) on the development of depression. However, it is unclear whether the gene x environment interaction predicts suicide attempts specifically. In addition, previous studies have not examined different forms of childhood abuse separately. In the current study, we found that 5-HTTLPR genotype moderated the link between childhood physical and sexual, but not emotional, abuse and adult psychiatric inpatients' histories of suicide attempts.     

Further examination of the psychometric properties of the comprehensive effects of alcohol questionnaire

Although the expectancies component of the Comprehensive Effects of Alcohol Questionnaire has previously been shown to be factorially valid, the factor structure of its valuations component has not previously been examined. The aims of this paper were: (i) to replicate the factor structure of the expectancies items; (ii) to explore the factor structure of the valuations items; and (iii) to investigate the utility of using the Comprehensive Effects of Alcohol Questionnaire to predict drinking behavior. The questionnaire was administered to 1004 university students along with measures of quantity and frequency of alcohol consumption. Fromme, Stroot, and Kaplan's (1993) factor structure of the expectancies scales was replicated. The factor structures of the negative valuations scales were characterized by 2 rather than 3 factors. Negative expectancies improved upon the prediction of drinking quantity and frequency over-and-above positive expectancies, and valuations further improved prediction over-and-above expectancies. Theoretical and clinical implications are discussed.     

The Five-Factor model of personality and work behaviour in Greece

This study explores the validity of the five-factor model of personality (FFM) in occupational settings in Greece, examining its relationship to employees' overall job performance, job satisfaction, organizational citizenship behaviour, and generic work competencies. Two hundred and twenty-seven employees from various Greek SMEs participated in the study completing a personality and a job satisfaction measure. Their supervisors completed three questionnaires assessing their performance and their work competencies. Some of the most significant results of this study were the strong links identified between personality and job satisfaction and the moderating effect of job type on the criterion-related validity of some personality dimensions. These results are discussed in terms of the FFM literature taking into consideration the strong effect of Greek culture. The theoretical and practical implications for research and practice in Greece are also discussed.     

The integration problem for naive realism

This paper makes explicit the basic problem perfect hallucinations pose for perceptual naive realists, more fundamental than the well-trodden Screening-off Problem. The deeper problem offers the basis for an overarching classification of the available naive- realist-friendly approaches to perfect hallucinations. In the course of laying out the challenges to the different types of response, the paper makes a case for the superiority of a particular approach to perfect hallucinations, on which they would be understood as a special kind of perceptual anomaly—arising from a secondary mode of perceptual processing.     

Social support as a predictor of variability: an examination of the adjustment trajectories of recent widows

The variability pattern of emotional well-being in recent widows across a 98-day period beginning in the first month post-loss has previously been modeled by dynamical systems and shown to be an oscillating process that damps across time. The goal of the present study was to examine how variables that comprise the social support network predict characteristics of these emotional shifts in 28 recent widows. In the present study, emotional support seeking led to a steeper overall trend, whereas perceived control for social support led to a shallower overall trend. When examining intraindividual variability, instrumental support seeking predicted a slower damping rate. Understanding the individual differences in the variability patterns of recent widows is a necessary step in identifying the etiology of adjustment to widowhood.