EAR DIFFERENCES IN EVALUATING EMOTIONAL OVERTONES OF UNFAMILIAR SPEECH BY JAPANESE AND ISRAELIS

Forty Japanese and 31 Israeli students evaluated the intensity of positive and negative emotional overtones of unfamiliar speech passages delivered to one ear, while hearing white noise in the other ear. The results indicated that (1) the Israelis evaluated as more intense the negative overtones, while the Japanese evaluated both positive and negative overtones as being about equally intense; (2) that the emotional overtones were evaluated as more intense in the left ear by the Japanese, and in the right ear by the Israelis; and (3) that females evaluated as relatively more intense the negative overtones, while males evaluated both overtones as being equally intense. The findings are discussed in terms of possible cultural effects on cerebral function.     

A method for calibrating an eye-monitoring system for use with infants

An algorithm for calibrating data from an infrared corneal reflection eye movement monitor is described. The algorithm is designed for use with infants and other noninstructable subjects.     

Errorless establishment of visual discrimination using fading procedures

A visual discrimination task involved presenting a triangle briefly as a sample. When it was withdrawn, this triangle and two others differing slightly in degree of rotation were presented in different positions, with S required to locate the sample that had been presented. Discrimination proved difficult for preschool children. When only the correct triangle was illuminated, discrimination was readily established. The brightness difference between correct and incorrect matches was gradually faded out by increasing the intensity of the incorrect matches, until they were equal in brightness to the correct match. The discrimination established by brightness difference was maintained in its absence, thereby transferring stimulus control from brightness to form, in an almost errorless sequence.     

Machine definition of ongoing silent and oral reading rate

A procedure is described by which a machine defines the ongoing silent and oral reading rates, and thus subjects them to environmental control and experimental analysis. Reading is considered as a form of monitoring in which response sequences are linear and successive. Applications for other types of monitoring are considered.

A page is projected on a screen, and the subject is required to read, aloud or silently. Through the same optical system, an opaque loop is presented that masks the projection, and a transparent slit on the opaque loop exposes part of a line of type. With each frame, the slit moves linearly and sequentially, exposing successive reading material. Recycling the loop triggers the presentation of another page. The subject controls the loop by pressing a micro-switch to advance the frame, thereby explicitly defining a monitoring response. The procedure is sensitive to variables such as signal-noise ratio, item difficulty, transient and long-term effects, reinforcement schedules (pay-offs), and age. Monitoring rates are extremely steady, suggesting their use as a base line.

Procedures are suggested for training subjects to be differentially attentive to different parts of a complex display.

     

The effect of pre-cueing on spatial attention across perception and action

It is well established that processes of perception and action interact. A key question concerns the role of attention in the interaction between perception-action processes. We tested the hypothesis that spatial attention is shared by perception and action. We created a dual-task paradigm: In one task, spatial information is relevant for perception (spatial-input task) but not for action, and in a second task, spatial information is relevant for action (spatial-output task) but not for perception. We used endogenous pre-cueing, with two between-subjects conditions: In one condition the cue was predictive only for the target location in the spatial-input task; in a second condition the cue was predictive only for the location of the response in the spatial-output task. In both conditions, the cueing equally affected both tasks, regardless of the information conveyed by the cue. This finding directly supports the shared input-output attention hypothesis.     

Stress modulation of cognitive and affective processes

This review summarizes the major discussion points of a symposium on stress modulation of cognitive and affective processes, which was held during the 2010 workshop on the neurobiology of stress (Boulder, CO, USA). The four discussants addressed a number of specific cognitive and affective factors that are modulated by exposure to acute or repeated stress. Dr David Morilak discussed the effects of various repeated stress situations on cognitive flexibility, as assessed with a rodent model of attentional set-shifting task, and how performance on slightly different aspects of this test is modulated by different prefrontal regions through monoaminergic neurotransmission. Dr Serge Campeau summarized the findings of several studies exploring a number of factors and brain regions that regulate habituation of various autonomic and neuroendocrine responses to repeated audiogenic stress exposures. Dr Kerry Ressler discussed a body of work exploring the modulation and extinction of fear memories in rodents and humans, especially focusing on the role of key neurotransmitter systems including excitatory amino acids and brain-derived neurotrophic factor. Dr Israel Liberzon presented recent results on human decision-making processes in response to exogenous glucocorticoid hormone administration. Overall, these discussions are casting a wider framework on the cognitive/affective processes that are distinctly regulated by the experience of stress and some of the brain regions and neurotransmitter systems associated with these effects.     

Hippocampal PKA/CREB pathway is involved in the improvement of memory induced by spermidine in rats

Spermidine (SPD) is an endogenous polyamine that modulates N-methyl-D-aspartate (NMDA) receptor function, and has been reported to facilitate memory formation. In the current study we determined whether or not the PKA/CREB signaling pathway is involved in SPD-induced facilitation of memory of inhibitory avoidance task in adult rats. The post-training administration of the cAMP-dependent protein kinase (PKA) inhibitor, N-[2-bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide [H-89, 0.5 ρmol intrahippocampal (ih)] or the antagonist of the NMDA receptor polyamine-binding site (arcaine, 0.02 nmol ih) with SPD (0.2 nmol ih) prevented memory improvement induced by SPD. Intrahippocampal administration of SPD (0.2 nmol) facilitated PKA and cAMP response element-binding protein (CREB) phosphorylation in the hippocampus 180 min, but not 30 min, after administration, and increased translocation of the catalytic subunit of PKA into the nucleus. Arcaine (0.02 nmol) and H-89 (0.5 ρmol) prevented the stimulatory effect of SPD on PKA and CREB phosphorylation. These results suggest that memory enhancement induced by the ih administration of SPD involves the PKA/CREB pathways in rats.