Neural functions of calcineurin in synaptic plasticity and memory

Major brain functions depend on neuronal processes that favor the plasticity of neuronal circuits while at the same time maintaining their stability. The mechanisms that regulate brain plasticity are complex and engage multiple cascades of molecular components that modulate synaptic efficacy. Protein kinases (PKs) and phosphatases (PPs) are among the most important of these components that act as positive and negative regulators of neuronal signaling and plasticity, respectively. In these cascades, the PP protein phosphatase 2B or calcineurin (CaN) is of particular interest because it is the only Ca(2+)-activated PP in the brain and a major regulator of key proteins essential for synaptic transmission and neuronal excitability. This review describes the primary properties of CaN and illustrates its functions and modes of action by focusing on several representative targets, in particular glutamate receptors, striatal enriched protein phosphatase (STEP), and neuromodulin (GAP43), and their functional significance for synaptic plasticity and memory.     

Elaboration et validation de tests de jugement situationnel comme outil de sélection professionnelle : guide méthodologique

Current views in personnel selection recognize the necessity for situational judgements tests (SJT) which are closed to the real work context of companies. The SJTs have also become a popular selection tool across Europe. SJTs are attractive because they show good validity, positive applicants reactions and can be cost effective to test large group of applicants at once. The aim of this paper is to describe a structured methodology for the elaboration of such test. Each stage is illustrated by examples and psychometrics validation issues are discussed.     

L’évaluation de la formation à l’harmonisation travail-vie personnelle : bilan et perspectives de recherche

The present article offers a review of the literature evaluating work-life balance training (which includes work-family balance training). The research, spanning over 43 databases, allowed the identification of 17 pertinent peer-reviewed articles. The selected studies are analysed in light of their main characteristics (design, sample, intervention, outcomes, etc.). The analysis shows that the offering of work-life balance training benefits both employees and managers. The methodological presuppositions and limitations of the selected studies are then critically examined. Lastly, possible topics for further research, such as the importance of conducting comparative researches and of adopting quasi-experimental and experimental protocols, are suggested in manner of conclusion.     

Sentiments d’efficacité personnelle et dynamique du projet professionnel

The present study explored the relations of emotional self-efficacy, career indecision and motivation in a sample of 200 French university students. Results from standard multiple regression analyses showed that emotional self-efficacy appeared the best predictor of intrinsic motivation toward education. The three dimensions of career indecision, as measured by CDDQ, do not revealed good predictors of intrinsic motivation. Concerning amotivation, inconsistent information (due to unreliable information, internal and external conflicts) is the best predictor of amotivation. Emotional self-efficacy also explains amotivation. The theoretical and practical implications of these findings are discussed.     

A critical evaluation of c as a measure of mnemonic resolution

It is known that visual working memory capacity is limited, but the nature of this limit remains a subject of controversy. Increasingly, two factors are thought to limit visual memory: an object-based limit associated with so-called "slots" models, and an information-based limit associated with resource models. Recently, Barton, Ester, and Awh (2009) introduced a measure of mnemonic resolution, which they dubbed c. We show here that c is critically flawed, and cannot be interpreted as a measure of resolution. We recommend strongly against its use and interpretation, and suggest alternatives approaches for researchers who want to explore mnemonic resolution.     

Parent attachment, childrearing behavior, and child attachment: Mediated effects predicting preschoolers' externalizing behavior

Attachment theory provides an interesting background for thinking about externalizing behavior (EB) in early childhood and for understanding how parenting influences the child's outcomes. The study examined how attachment and parenting could be combined to explain preschoolers' EB. Data were collected from 117 preschoolers aged from 4 to 6 clinically referred for EB and their parents from a middle-high income population. Child attachment was measured with the Attachment Q-set; parent's remembered attachment in the family of origin with the CaMir. Child attachment played a crucial role in mediating the link between parent attachment and EB as well as the link between parenting and EB. Paternal attachment displayed a direct and an indirect effect through controlling parenting and child attachment on child EB. Maternal attachment was a distal predictor associated with EB through child attachment, and independent of controlling parenting. These results are discussed with their applied and scientific implications.     

Is it dangerous? The role of an emotional visual search strategy and threat-relevant training in the detection of guns and knives

Counter-terrorism strategies rely on the assumption that it is possible to increase threat detection by providing explicit verbal instructions to orient people's attention to dangerous objects and hostile behaviours in their environment. Nevertheless, whether verbal cues can be used to enhance threat detection performance under laboratory conditions is currently unclear. In Experiment 1, student participants were required to detect a picture of a dangerous or neutral object embedded within a visual search display on the basis of an emotional strategy ‘is it dangerous?’ or a semantic strategy ‘is it an object?’. The results showed a threat superiority effect that was enhanced by the emotional visual search strategy. In Experiment 2, whilst trainee police officers displayed a greater threat superiority effect than student controls, both groups benefitted from performing the task under the emotional than semantic visual search strategy. Manipulating situational threat levels (high vs. low) in the experimental instructions had no effect on visual search performance. The current findings provide new support for the language-as-context hypothesis. They are also consistent with a dual-processing account of threat detection involving a verbally mediated route in working memory and the deployment of a visual template developed as a function of training.     

Review of Teresa Obolevitch: Faith and Science in Russian Religious Thought

Studies in East European Thought -