Evaluation of a Heredofamilial Cancer Unit in Increasing Family History Collection and Genetic Counseling Referrals Among Spanish Oncologists at a University Hospital

A comprehensive family history is essential to identify patients at risk for hereditary cancer who could benefit from genetic counseling (GC). In a previous study, we observed a low occurrence of family history record (FHR) collection rate and GC referral among oncologists at our institution. The present work analyzes whether the implementation of a heredofamilial cancer unit (HFCU) would improve these parameters. We retrospectively compared the FHR rate in clinical records, National Cancer Institute (NCI) general criteria for hereditary cancer suspicion, GC referrals and FHR quality in two cohorts: cohort 1 (patients diagnosed before HFCU creation) and cohort 2 (after HFCU creation). Of 1,175 patients (590 cohort 1 and 585 cohort 2), FHRs were consigned in 27.3 % and 52.5 % of patients, respectively (p?<?0.001). The GC referral of patients with any NCI criterion was 13.6 % xin cohort 1 vs. 40.5 % in cohort 2 (p?<?0.001). FHR quality improved in terms of the total number of relatives (164 vs. 314, p?=?0.1, N.S.) and number of healthy relatives consigned (80 vs. 191, p?<?0.01). Nine mutations (6 BRCA, 1 MEN1, 2 Lynch), 4 unknown significance variants (all in BRCA) and 2 with no mutation were identified among patients referred from cohort 2. We conclude that the creation of a heredofamilial cancer unit has changed both FHR and GC referrals among oncologists at our institution, although continuous educational efforts are required.     

Personalized Genomic Results: Analysis of Informational Needs

Use of genomic information in healthcare is increasing; however data on the needs of consumers of genomic information is limited. The Coriell Personalized Medicine Collaborative (CPMC) is a longitudinal study investigating the utility of personalized medicine. Participants receive results reflecting risk of common complex conditions and drug—gene pairs deemed actionable by an external review board. To explore the needs of individuals receiving genomic information we reviewed all genetic counseling sessions with CPMC participants. A retrospective qualitative review of notes from 157 genetic counseling inquiries was conducted. Notes were coded for salient themes. Five primary themes; “understanding risk”, “basic genetics”, “complex disease genetics”, “what do I do now?” and “other” were identified. Further review revealed that participants had difficulty with basic genetic concepts, confused relative and absolute risks, and attributed too high a risk burden to individual single nucleotide polymorphisms (SNPs). Despite these hurdles, counseled participants recognized that behavior changes could potentially mitigate risk and there were few comments alluding to an overly deterministic or fatalistic interpretation of results. Participants appeared to recognize the multifactorial nature of the diseases for which results were provided; however education to understand the complexities of genomic risk information was often needed.     

Social anxiety and interpretation of ambiguous smiles

This study investigated whether social anxiety facilitates the discrimination between genuine and ambiguous smiles. Socially anxious (N=20) and nonanxious (N=20) participants categorized as “happy” or “not happy” faces with either (1) a truly happy expression (i.e., happy eyes and a smile), (2) truly nonhappy expressions (e.g., angry eyes and an angry mouth), or (3) blended expressions with a smiling mouth and nonhappy (e.g., angry, sad, etc.) eyes. Results indicated that, relative to nonanxious participants, those high in social anxiety were more likely to judge as “not happy” any blended expression with nonhappy eyes, and they were faster in judging as “not happy” the blended expressions with angry, fearful, or disgusted eyes (but not those with sad, surprised, or neutral eyes). These results suggest, respectively, that social anxiety inhibits a benign interpretation of all the ambiguous expressions with a smile, and speeds up the detection of threatening eyes in such expressions. Importantly, no differences appeared as a function of social anxiety for truly happy or nonhappy faces. This rules out a response-bias explanation, and also reveals that social anxiety does not affect sensitivity in the recognition of prototypical expressions.     

The Relationships Among Parental Anxiety, Parenting, and Children’s Anxiety: The Mediating Effects of Children’s Cognitive Vulnerabilities

Theoretical models have emphasized the roles played by parental anxiety and behavior in the development of childhood anxiety problems. Little is known regarding the differential impacts of mothers and fathers or regarding the processes that mediate these influences. The present study examines the relationships between maternal and paternal trait anxiety, overprotection, and emotional support on the one hand and anxiety symptoms in children on the other hand. This study also explores the mediating role of children’s cognitive vulnerabilities to anxiety disorders in the relationship between parental variables and children’s anxiety. A sample of 80 children and their parents (fathers and mothers), selected from an initial screening of 905 school-aged children, participated in this study. The results indicate that both parents had unique influences on children’s anxiety symptoms: maternal trait anxiety and paternal overprotection and concern were found to independently and positively contribute to children’s anxiety. Furthermore, children’s interpretative biases mediated the relation between maternal trait anxiety and children’s anxiety symptoms. The results of this study underline the importance of considering both paternal and maternal factors in the development of children’s anxiety problems. These findings also have implications for theoretical models of the etiology of anxiety and for the treatment of these problems in children.     

William J. Morgan’s ‘conventionalist internalism’ approach. Furthering internalism? A critical hermeneutical response

Several authors, such as William J. Morgan, John S. Russell and R. Scott Kretchmar, have claimed that the limits between the diverse normative theories of sport need to be revisited. Most of these works are philosophically grounded in Anglo-American philosophical approaches. For instance, William J. Morgan’s proposal is mainly based on Richard Rorty’s philosophy. But he also discusses with some European philosophers like Jürgen Habermas. However, Habermas’ central ideas are rejected by Morgan. The purpose of this paper is to analyse Morgan’s rejection of Habermas’ thought and show that a more appropriate normative of sport that explains better our current sporting world can be achieved by drawing on the German philosopher’s ideas. The plan of this paper is the following. It shall analyse the limits of the distinction between broad internalism and externalism by taking Morgan’s work as its starting point. To do so, firstly, the conventionalist way in which Morgan criticises the limits of interpretivism shall be explained (§2). Secondly, the relationship between Morgan’s proposals and the hermeneutical theories which are at the roots of his proposal shall be brought to light. Thirdly, since Morgan takes Habermas’ hermeneutical ethics to be an example of externalism, the relationship between his theory and Habermas’ ethical account shall be clearly defined. Moreover, Morgan’s proposal shall be criticised in the light of Habermas’ discourse ethics (§3). To conclude, a Habermasian approach in sport ethics shall be described (§4).     

Temperament and Personal Wellbeing in a Sample of 12 to 16 Year-Old Adolescents

Working on the basis that temperament – understood as the root from which personality traits emerge – is related to subjective wellbeing, a study was conducted on a sample of 1.483 students in compulsory secondary education aged between 12 and 16, half of whom attended schools in a rural or semiurban area and half in an urban setting. The aims of the study were as follows: a) to determine the level of personal wellbeing in a sample of 12 to 16 year-old adolescents measured using scores obtained from the Personal Wellbeing Index (PWI), and b) to analyse the relationship between temperament, measured using the Early Adolescent Temperament Questionnaire (EATQ-R), and personal wellbeing. Results indicate, among other things, that those temperament dimensions which best predict a high level of personal wellbeing are activity level, affiliation, shyness (with a negative weight), inhibitory control and activation control.     

The effect of spatial organization of targets and distractors on the capacity to selectively memorize objects in visual short-term memory

We conducted a series of experiments to explore how the spatial configuration of objects influences the selection and the processing of these objects in a visual short-term memory task. We designed a new experiment in which participants had to memorize 4 targets presented among 4 distractors. Targets were cued during the presentation of distractor objects. Their locations varied according to 4 spatial configurations. From the first to the last configuration, the distance between targets’ locations was progressively increased. The results revealed a high capacity to select and memorize targets embedded among distractors even when targets were extremely distant from each other. This capacity is discussed in relation to the unitary conception of attention, models of split attention, and the competitive interaction model. Finally, we propose that the spatial dispersion of objects has different effects on attentional allocation and processing stages. Thus, when targets are extremely distant from each other, attentional allocation becomes more difficult while processing becomes easier. This finding implicates that these 2 aspects of attention need to be more clearly distinguished in future research.     

Gender‐typing of leadership: Evaluations of real and ideal managers

This research focuses on female underrepresentation in managerial positions. Specifically, two studies examine gender‐typing for managerial roles in Spain using ratings for real and ideal managers. In addition, we analyse the existence of same‐gender bias on evaluations of the behavior of actual leaders. In the first study, 195 Spanish workers evaluate the extent to which gender‐stereotypical traits are important for becoming a successful middle manager in three conditions (female managers, male managers, and managers in general). In the second study, we explore the degree to which the behavior of real Spanish managers is gender‐typed and the existence of same‐gender bias on leadership styles – transformational, transactional and avoidant/passive – and on leadership outcomes – effectiveness, extra effort and satisfaction – from the perspective of subordinates (N = 605). Overall, the results demonstrate that masculine characteristics were rated as more important than feminine characteristics for managerial positions, and they were more often assigned to male managers than to female managers. Unexpectedly, this manager‐male association is stronger among female participants than among male participants. Our findings also demonstrate that women subordinates evaluate their same‐sex supervisors more favorably in transformational leadership, effectiveness, and extra effort. The negative consequences derived from gender‐typing managerial positions are highlighted according to the role congruity theory of prejudice toward female leaders. The positive effects of in‐group female bias on behavior ratings are also noted. The mixed implications of these results for women's advancement to leadership positions are discussed.     

Suicide attempts and stressful life events among female victims of intimate partner violence living in poverty in Nicaragua

This article describes a study of 136 female intimate partner violence victims living in poverty in Nicaragua. The paper aimed to analyze the relationship between experiencing stressful life events (SLE) and perceived social support with suicide attempts, and to evaluate the differences in the SLE experienced by female suicide attempters versus non‐attempters. The results showed the existence of a high level of SLE among the interviewees, and that women who have attempted suicide have experienced substantially more of these events. Experiences of violence and less social support were especially related to suicide attempts among the interviewees.     

How orthographic transparency affects morphological processing in young readers with and without reading disability

This study investigates how orthographic modifications to the stems of complex words affect morphological processing in proficient young Spanish readers and children with reading deficits. In a definition task all children, irrespective of their reading skill, were worse at defining derived words that had an orthographic alteration of the base stem than words with no orthographic alteration. In a go/no‐go lexical decision task, an interaction between base frequency and orthographic alteration was found: base frequency affected derived words with no orthographic alteration more than words with alterations, irrespective of reading skill. Overall, results show that all children benefit from a high frequency base, skilled children outperform children with reading deficits and morphological processing is affected by orthographic alterations similarly in proficient and impaired readers.