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61.
A literature search was conducted on studies of new drugs used with patients with schizophrenia reported by U.S. and non-U.S. researchers from 1966–1993, yielding 41 U.S., and a total of 24 other non-U.S. studies, among them 11 British studies. Results of the U.S. and non-U.S. studies were pooled separately and compared. Among several comparable conditions discussed, the lack of any data on suicides in the U.S. studies was observed. For a second statistical analysis of suicide rates ‘person-years’ were calculated to adjust for differing washout durations. The results obtained include findings that the percentage of patients relapsing in U.S. studies was slightly lower (37.9%) than in non-U.S. studies (46%); the percentage of patients dropping out in U.S. studies (10.5%) was higher than in non-U.S. studies (7.6%); known location of dropout patients in U.S. studies was 1.7%, compared to 2.6% in non-U.S. studies. The most interesting finding was that no suicides were reported in U.S. studies, compared to 0.6% of patients reported in British studies. Some U.S. studies used ‘challenge doses’, such as amphetamines or L-dopa; no non-U.S. studies reported their use. Compared to U.S. studies, those by non-U.S., and particularly British, researchers appeared to report adverse events in their studies. ‘Challenge’ drugs were not used; suicides were reported. It is estimated that the probability that no patients suicided who participated in the U.S. is small—one in 500. 相似文献
62.
Clinical pragmatism: a method of moral problem solving 总被引:3,自引:0,他引:3
This paper presents a method of moral problem solving in clinical practice that is inspired by the philosophy of John Dewey. This method, called "clinical pragmatism," integrates clinical and ethical decision making. Clinical pragmatism focuses on the interpersonal processes of assessment and consensus formation as well as the ethical analysis of relevant moral considerations. The steps in this method are delineated and then illustrated through a detailed case study. The implications of clinical pragmatism for the use of principles in moral problem solving are discussed. 相似文献
63.
Richard L. Port Heather A. Murphy R. DAniel Miller Kevin S. Seybold 《Current psychology (New Brunswick, N.J.)》1997,15(4):332-339
present research examined the role of hippocampal NMDA-dependent synaptic potentiation on appetitive instrumental conditioning
under a continuous reinforcement schedule. In the first experiment, low (.025 mg.kg) or moderate (.05 mg/kg) dosages of the
NMDA receptor antagonist, MK801, failed to increase the number of training days required to reach acquisition criterion; number
of training days required to reach criterion for extinction were also unaffected. In the second experiment, a higher dosage
(.10 mg/kg) of MK801 or induction of long-term potentiation failed to alter the number of responses occurring during acquisition.
These data suggest that hippocampal synaptic potentiation does not play a prominent role in instrumental learning with simple
contingency conditions. It is suggested that hippocampal LTP reflects a perceptual process that contributes differentially
to spatial cognition, classical and instrumental conditioning. 相似文献
64.
Richard L. Port Heather A. Murphy R. DAniel Miller Kevin S. Seybold 《Current Psychology》1997,15(4):332-339
present research examined the role of hippocampal NMDA-dependent synaptic potentiation on appetitive instrumental conditioning
under a continuous reinforcement schedule. In the first experiment, low (.025 mg.kg) or moderate (.05 mg/kg) dosages of the
NMDA receptor antagonist, MK801, failed to increase the number of training days required to reach acquisition criterion; number
of training days required to reach criterion for extinction were also unaffected. In the second experiment, a higher dosage
(.10 mg/kg) of MK801 or induction of long-term potentiation failed to alter the number of responses occurring during acquisition.
These data suggest that hippocampal synaptic potentiation does not play a prominent role in instrumental learning with simple
contingency conditions. It is suggested that hippocampal LTP reflects a perceptual process that contributes differentially
to spatial cognition, classical and instrumental conditioning. 相似文献
65.
Abstract— Becoming a proficient symbol user is a universal developmental last in the first years of life, but delecting and mentally representing symbolic relations can be quite challenging for young children To test the extent to which symbolic reasoning per se is problematic, we compared the performance of 2-year-olds in symbolic and nonsymbolic versions of a search task. The children had to use their knowledge of the location of a toy hidden in a room to draw an inference about where to find a miniature toy in a scale model of the room (and vice versa) Children in the nonsymbolic condition believed a shrinking machine had caused the room to become the model They were much more successful than children in the symbolic condition, for whom the model served as a symbol of the room The symbol understanding and use. 相似文献
66.
Eamonn Ferguson Tom Cox William Farnsworth Kirstin Irving Michael Leiter 《Journal of applied social psychology》1994,24(10):926-940
Final-year nursing students (N= 96) described their anxieties about biohazards, not only in relation to the occupational context of a hospital ward, but also in relation to their general life context. These contexts were reported to vary in the extent to which they permitted control over exposure to the two particular biohazards chosen for study: human immunodeficiency virus (HIV) and hepatitis B virus (HBV). The data showed that nurses' anxiety about contracting HIV infection varied significantly across the two contexts, while anxiety about contracting HBV infection did not. In the general life context, anxiety about HIV was greater than anxiety about HBV for all subjects. This difference was significantly greater for those with incorrect knowledge about objective HIV seroconversion rates than for those with correct knowledge. 相似文献
67.
Rowland S. Miller 《Journal of personality》1995,63(2):315-339
In this study, the correlates of embarrassability, or chronic susceptibility to embarrassment, were examined. Competing theoretical models suggest either that embarrassable people should be especially concerned about others' evaluations of them or that they should lack social skills. Further, shyness and embarrassment are typically considered to be closely related states. To test these propositions, 310 participants provided extensive self-reports of social skill, fear of negative evaluation, self-esteem, self-consciousness, and negative affectivity. Regression and factor analyses indicated that, compared to those of low embarrassability, highly embarrassable people are particularly concerned with the normative appropriateness of behavior and are more motivated to avoid rejection from others. In contrast, shyness was best predicted by low social self-confidence and low social skill. The data best support a social-evaluation model of embarrassment and argue that embarrassability is linked to the appropriateness of social behavior, and shyness to its effectiveness. 相似文献
68.
Todd Q. Miller C. David Jenkins George A. Kaplan Jukka T. Salonen 《Journal of applied social psychology》1995,25(13):1142-1168
Few studies have examined the correlational and structural relationships between measures of hostility that may predict coronary heart disease. Using data from a population-based study (N= 2,682), we examined the factor structure among the five subscales from Siegel's (1986) Multi-dimensional Anger Inventory, the three subscales from Spielberger et al.'s (1985) anger expression scales, a Cook-Medley (Cook & Madley, 1954) hostility subscale that measures cynicism, and items measuring hostility from four scales that assess Type A behavior. Eight separate factors were identified: hostile anger expression, perceived control over the expression of one's anger, frequency of anger, ease of anger provocation, brooding, hostile outlook, cynicism, and sullenness. These results suggest that the structure of hostility measures is more complex than previous factor analyses have suggested. Our findings point to the dangers in assuming that a factor structure can be generalized beyond the data on which it is based to provide theoretical statements about psychological structure. The new scales appear to be valid because they correlate with demographic variables and indicators of social support in the expected directions. 相似文献
69.
The published literature on the relationship between behavioral intentions and fertility behavior exhibits four major problems: inconsistent and confusing use of theoretical constructs, limited use of different types of intentions, use of nonbehavioral outcomes, and failure to explore adequately the couple aspects of the intentions/behavior relationship. The study reported here addresses these problems by using a theoretical framework that characterizes the psychological/behavioral sequence leading to a planned conception, three different types of fertility intentions, a behavioral outcome variable, and data from 196 married couples with no children and 185 married couples with one child. Data analysis results in a simultaneous equation, constrained regression model which indicates that child-timing intentions are the most important predictors of proceptive behavior over a 3-1/2 year period and that childbearing intentions are next in importance; that behavioral intentions are the final common pathway through which fertility motivations, attitudes, beliefs, and desires affect behavior; that the use of proceptive behavior as an outcome variable improves the explanatory power of our models; and that the interaction of couple intentions do not demonstrate greater husband or wife influence over couple proceptive behavior but do demonstrate that disagreement has a delaying effect on the onset of that behavior. 相似文献
70.
Kevin J. Miller Barbara S. McCrady David B. Abrams Erich W. Labouvie 《Journal of psychopathology and behavioral assessment》1994,16(2):111-120
The present study reports on a clinical instrument designed for assessing self-efficacy in alcoholics. In contrast to studies that construct general measures, it was proposed that taking an individualized approach to assessment might offer an effective methodology. Thirty-four alcoholics in an outpatient, behaviorally oriented treatment program participated as subjects. During therapy, an Individualized Self-Efficacy Survey (ISS) was developed for each subject. The ISS was developed by (a) administering the Drinking Patterns Questionnaire (DPQ) to identify important problem areas (e.g., work, children, marital) and specific drinking antecedents and (b) constructing a 15-item scale using each drinker's most important cues. The utility of having clients choose their own items was supported by finding a significant relationship between problem areas identified as important on the DPQ and the areas reported as surrounding relapse. ISS ratings were reflective of efficacy changes during treatment, while posttreatment ISS scores were predictive of subsequent relapse. Situation-specific prediction of relapse was not found. The advantages of this methodology for clinical use are discussed, while general directions for future research are suggested. 相似文献