Localized disruption of Narp in medial prefrontal cortex blocks reinforcer devaluation performance

Neuronal activity regulated pentraxin (Narp) is a secreted protein that regulates α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors (AMPAR) aggregation and synaptogenesis. Mapping of Narp-positive neurons in brain has revealed it is prominently expressed in several limbic system projection pathways. Consistent with this localization pattern, Narp knockout mice show deficits in using the current value of a reinforcer to guide behavior, a critical function of the limbic system. To help assess whether this behavioral deficit is due to impairment of synaptogenesis during development or in modulating synaptic signaling in the mature brain, we have used a dominant negative Narp viral construct which blocks trafficking of endogenous Narp to axons. Focal injection of this viral construct into the medial prefrontal cortex (mPFC) of adult mice, a region containing Narp-positive projection neurons, blocked reinforcer devaluation. Thus, these results indicate that Narp released from mPFC neurons plays a key role in mediating synaptic changes underlying instrumental reinforcer devaluation.     

一个参与者眼中的行为遗传学史上的里程碑

行为遗传学的历史,从横切面看,就好似一个由心理学、遗传学、生物学、进化论、人类学、人口学、生物统计、社会学以及法哲学等学科组合成的万花筒。任何一对学科的演进都呈正相关。虽然任何一对学科都不至于相互否定,但是,他们各自独特的历史和人物,又使得每一对学科并不完全相似     

Comparison of Media-Literacy Programs to Strengthen College Women's Resistance to Media Images

This study examined whether, in comparison to no-intervention and video-only intervention control conditions, two distinct media literacy interventions could promote media skepticism and reduce negative body image in a sample of college women ( N = 110). It was expected that an externally oriented ( i.e., feminist sociocultural) media literacy intervention would have its greatest impact on measures related to media skepticism, while an internally oriented ( i.e., cognitive) intervention would have its greatest impact on measures related to negative body image. Contrary to expectations, in comparison to the no-intervention condition, both media literacy interventions were similar in effectiveness to a video-only ("Slim Hopes," Kilbourne, 1995) condition in increasing participants' skepticism about the realism, similarity, and desirability of media that depict a thin ideal of beauty. There were no between-group differences on negative body image at posttest, suggesting that negative attitudes about one's body may require more extensive, longer-term interventions.     

Theory in counselling: Using content knowledge

An underlying theoretical principle of person‐centred counselling is that this approach has no requirements for a content knowledge base in terms of client groups and client issues. This is also the position implicit in UK professional accreditation criteria. Yet counsellors do acquire and do use content knowledge in addition to knowledge of process. Thus professional ethos and professional practice are, it is suggested, at variance.     

Isaiah Shembe, Zulu Religious Leader

Do you want to understand yourself?Look how others behave;Do you want to understand others?Look in your own heart.Willst du dich selber erkennen,so sieh, wie die andern es treiben;Willst du die andern verstehn,blick in dein eigenes Herz.(Schiller)¹This paper deals with some problems encountered by scholars who attempt to study Primal Religions.²It focuses on an examination of the major scholarly literature and some traditions surrounding perceptions of the Zulu religious leader Isaiah Shembe.³It has nine sections: The Problem of Prejudice, Isaiah Shembe: Zulu Prophet or Black Christ?, The Judgement of Shembe's Successors, Literary Norms and Living Traditions, Studying Living Religions, The Role of Primal Experiences, The Importance of Mythology, Getting One's Hands Dirty, and Who was Isaiah Shembe?     

A modification of kendall's tau for measuring association in contingency tables

A coefficient of association is described for a contingency table containing data classified into two sets of ordered categories. Within each of the two sets the number of categories or the number of cases in each category need not be the same.=+1 for perfect positive association and has an expectation of 0 for chance association. In many cases also has –1 as a lower limit. The limitations of Kendall's _a and _b and Stuart's _c are discussed, as is the identity of these coefficients to' under certain conditions. Computational procedure for is given.     

The effects of instructional set on physiological response to stressful imagery

Centrally mediated or cognitive variables have received considerable attention in clinical research. With the establishment of the effectiveness of such specific treatment techniques as systematic desensitization (Paul. 1969a. 1969b). a question arises as to the influence of cognitions on process and outcome variables in such learning based treatments (Lang. 1971). Research investigating the influence of demand characteristics and subject expectancies has demonstrated such centrally mediated variables can significantly influence overt, behavioral and self-report measures of fear, stress, or anxiety (cf. Borkovec. 1972: Marcia. Rubin and Efran. 1969; McGlynn. Maelia and Nawas. 1969: McGlynn. Reynolds and Linder. 1971: Oliveau. Agras. Leitenberg and Wright. 1969; Rappaport. 1972: Rosen. 1974).However. Borkovec (1972) and Rappaport (1972) failed to obtain expectancy effects on physiological measures of anxiety. Neither investigation provided for an independent assessment of subjects' actual expectancies, or belief in the instructions, as recommended by Davison and Wilson (1973). Borkovec administered clinical procedures over four sessions and varied the information communicated about the ‘purpose’ of the treatments (physiological versus therapeutic instructions). Differential rationales for differential expectancies of physiological reactivity were not provided. After each session, subjects reviewed the same false physiological records depicting reductions in fear responses. Although these changes were explained either physiologically or therapeutically. the fact that such reductions were emphasized should have attenuated differences between groups. Rappaport (1972) exposed subjects to a fearful stimulus and varied the suggestion and rationale for the pseudotreatment: no expectancy (stress research): therapeutic expectancy (fear reduction); and negative expectancy (fear increase). The lack of an independent assessment of the expectancy manipulation, as well as the exclusion of a specific therapeutic procedure, make it impossible to interpret the results in relation to expectancy effects on physiological fear responses during the administration of therapeutic procedures. There is other evidence, however, that suggestion and instructional set can significantly influence somatic and autonomic response systems (Barber. 1961. 1965; Sternbach. 1964. 1965).The primary purpose of this study was to evaluate the effects of instructional set on physiological responses to stressful imagery. This was an early step in a research program investigating the effects of instructional and informational variables on physiological responses of clinical interest. One half of the subjects received abbreviated live relaxation training (R) as described m a manual by Bernstein and Borkovec (1972) and based upon the original work of Jacobson (1938). The other half received an inert placebo pill and undertook a target detection task (P). The latter procedure was similar to that used by Paul (1966). Although both procedures had previously been shown to have relaxing effects, the P task was included as an additional control for any potential effects specific to the tension-release procedure of R. In order to evaluate the effects of instructional set, one half of each of the above two groups received instructions designed to lead to an expectancy of response inhibition to stressful imagery by the respective procedure (Decrease Stress Response. DSR). while the other half received instructions designed to lead to an expectancy of an increased response to stressful imagery by the respective procedure (Increase Stress Response. ISR). Each subject visualized three individually specified items that were the most frightening scenes imaginable prior to training and four times after training visualized the scene producing the largest response. Considerable effort was devoted to eliciting from each subject the most frightening items possible for her. and it was clear from subject comments that the items did elicit negative emotional responses.Since previous research (Barber. 1961. 1965; Sternbach. 1964. 1965) indicated that instructional set can influence physiological reactivity, it was hypothesized the DSR) subjects should exhibit a greater reduction in emotional response from pre- to posttraining than ISR subjects.     

Semantic memory verification of binary statements by children at three academic levels

Ninety-six binary statements were administered to 120 children randomly selected from three academic levels. The children were to respond TRUE or FALSE to each statement. Error count and latency for correct responses were used as measures of performance. The Constituent Comparison Model (Carpenter, P., & Just, M. A., Psychological Review, 1975, 82, 45–73), which postulates that verification latency will increase linearly with a linear increase in the number of hypothesized constituent comparisons, accounts quite well for the results obtained in this study. Furthermore, the results suggest an increasing efficiency in semantic memory verification across the three academic levels as reflected by a decrease in variability of performance, a decrease in the time required to read and encode sentences, and a decrease in the time required per constituent comparison.