Tryptophan Hydroxylase 1 Variant rs1800532 is Associated with Suicide Attempt in Serbian Psychiatric Patients but does not Moderate the Effect of Recent Stressful Life Events

Tryptophan hydroxylase 1 (TPH1) gene, coding for serotonin synthesizing enzyme, and recent stressful life events (SLEs) have been commonly associated with suicidal behavior. TPH1 has been also hypothesized to be involved in stress–response mechanisms. The aim of this study was to assess TPH1 variant rs1800532 and its possible interaction with recent SLEs as risk factors for suicide attempt (SA) in Serbian psychiatric patients, including 165 suicide attempters and 188 suicide nonattempters. rs1800532 and recent SLEs were independently associated with SA, while rs1800532 did not moderate the effect of recent SLEs on SA vulnerability among Serbian psychiatric patients.     

Social emotions and social cognition in the development of social anxiety disorder

ABSTRACT

Social anxiety disorder (SAD) is one of the most prevalent mental disorders with serious individual impairments and societal costs. Little is known about the mechanisms involved in SAD development. Here, I propose that dysregulated social emotions (social fear and shyness) are crucial for SAD development and that these dysregulated social emotions originate in the disturbances in socio-cognitive abilities. The research from our lab confirmed this. It showed that behavioural and physiological indices of social fear contribute to the development of SAD in toddlerhood and early childhood. Later in childhood, between ages 4.5 and 7.5, we found a new risk factor for SAD―dysregulated shyness. Specifically, we found that negative shy expressions and prolonged physiological blushing (temperature increase) contribute to SAD development. Whereas elevated fear may be rooted in deficits in socio-cognitive skills, dysregulated shyness may be rooted in advanced socio-cognitive abilities. These findings imply that dysregulated social emotions play an important role in SAD and should be explicitly targeted in clinical treatments of SAD.     

On the Nature of Philosophy

This paper claims that what philosophy primarily does is interpret our notions, offer ways of understanding these notions that are not scientific in nature but not contrary to science either. The paper draws a distinction between conceptual analysis, a highly constrained enterprise that is supposed to bring to light what was in the concept all along, and the interpretation of notions, a creative enterprise that offers ways of understanding notions that were not already prefigured by the content of these notions—philosophy consists in the latter, not the former. It explains how these interpretations are justified and what the difference is between better and worse interpretations. The remainder of the paper is organized around three headings: philosophy and science, philosophy and language, and philosophy and progress. It claims that in philosophy there is no real progress, but that philosophy does move forward because the notions at issue are endlessly interpretable.     

It’s not just “us” versus “them”: Moving beyond binary perspectives on intergroup processes

ABSTRACT

The social psychology of intergroup relations has emerged largely from studies of how one group of people (e.g., whites) think and feel about another (e.g., blacks). By reducing the social world to binary categories, this approach has provided an effective and efficient methodological framework. However, it has also obscured important features of social relations in historically divided societies. This paper highlights the importance of investigating intergroup relationships involving more than two groups and of exploring not only their psychological but also their political significance. Exemplifying this argument, we discuss the conditions under which members of disadvantaged groups either dissolve into internecine competition or unite to challenge the status quo, highlighting the role of complex forms of social comparison, identification, contact, and third-party support for collective action. Binary conceptualizations of intergroup relations, we conclude, are the product of specific sociohistorical practices rather than a natural starting point for psychological research.     

Humanism and Theoretical Pluralism

Christian Smith's What Is a Person? calls for a normative turn in sociology—the grounding of sociology in a theory of human nature. While offering a systematic account of a thick view of personhood—what it should look like, how it can be applied, and why it is needed—the book proposes a critical realist personalism as the best metatheoretical direction for sociology. The author of this essay agrees with the main questions and direction of Smith's project. However, by historicizing the origins and sociological implications of personalist moral theory, the author problematizes the personalism that is one of the foundations of Smith's project. She contrasts personalism with humanism, suggesting that the latter might possess both the normative robustness and comparative potential needed for contemporary sociological theory and practice. She ends her response to Smith's book by raising questions about the relationship between critical realist personalism and theoretical pluralism.