What do Patients Prefer: Informed Consent Models for Genetic Carrier Testing

The recent increased number of conditions for which patients can undergo genetic carrier testing raises the question of how best to obtain pre-test informed consent. Clinical approaches vary from a minimalist model to a model where patients are given detailed information about all conditions to be screened for. Few data exist as to patient preferences, or how information impacts decision-making. Eight high-literacy focus groups were conducted to assess the knowledge and preferences of pregnant patients and their male partners. Most groups indicated that some balance between details and brevity was optimal, recognizing that anxiety can occur when patients are provided with too much information and that the wide range of tests offered during pregnancy often led to confusion. Critical areas for the informed consent process included (1) details about the conditions and risk of being a carrier, (2) logistics of testing, (3) next steps if the test is positive, and (4) prognosis, options and resources if the child were to be affected with a disorder. It will be useful to develop model consent programs and prospectively assess their impact on informed consent and patient satisfaction, both when positive and negative results are received.     

What we know about what we have never heard: evidence from perceptual illusions

Are speakers equipped with preferences concerning grammatical structures that are absent in their language? We examine this question by investigating the sensitivity of English speakers to the sonority of onset clusters. Linguistic research suggests that certain onset clusters are universally preferred (e.g., bd>lb). We demonstrate that such preferences modulate the perception of unattested onsets by English speakers: Monosyllabic auditory nonwords with onsets that are universally dispreferred (e.g., lbif) are more likely to be classified as disyllabic and misperceived as identical to their disyllabic counterparts (e.g., lebif) compared to onsets that are relatively preferred across languages (e.g., bdif). Consequently, dispreferred onsets benefit from priming by their epenthetic counterpart (e.g., lebif-lbif) as much as they benefit from identity priming (e.g., lbif-lbif). A similar pattern of misperception (e.g., lbif-->lebif) was observed among speakers of Russian, where clusters of this type occur. But unlike English speakers, Russian speakers perceived these clusters accurately on most trials, suggesting that the perceptual illusions of English speakers are partly due to their linguistic experience, rather than phonetic confusion alone. Further evidence against a purely phonetic explanation for our results is offered by the capacity of English speakers to perceive such onsets accurately under conditions that encourage precise phonetic encoding. The perceptual illusions of English speakers are also irreducible to several statistical properties of the English lexicon. The systematic misperception of universally dispreferred onsets might reflect their ill-formedness in the grammars of all speakers, irrespective of linguistic experience. Such universal grammatical preferences implicate constraints on language learning.     

Automatic emotion regulation during anger provocation

Individuals frequently have to regulate their emotions, especially negative ones, to function successfully. However, deliberate emotion regulation can have significant costs for the individual. Are there less costly ways to achieve emotion regulatory goals? In two studies, we test the hypothesis that more automatic types of emotion regulation might provide the benefits of deliberate emotion regulation without the costs. Study 1 introduces a priming technique that manipulates automatic emotion regulation. Using this priming technique, we show that relative to priming emotion expression, priming emotion control leads to less anger experience in response to a laboratory anger provocation. Study 2 examines the experiential and physiological consequences of automatic emotion regulation. Results suggest that relative to priming emotion expression, priming emotion control reduces negative emotion experience without maladaptive cardiovascular responding. Together, these findings suggest that automatic emotion regulation may provide an effective means of controlling powerful negative emotions.     

Gene–Environment Interaction of the Oxytocin Receptor Gene Polymorphism (rs53576) and Unresolved Attachment Status Predict Depersonalization Symptoms: An Exploratory Study

Depersonalization (DP), or feelings of detachment from one’s self or one’s surroundings (i.e., derealization, DR), is considered a maladaptive stress response, frequently occurring in anxiety disorders, depression or as a primary disorder. However, the pathogenesis of DP/DR symptoms is little understood. The present study aimed to elucidate the influence of unresolved attachment status and the oxytocin receptor gene (OXTR) rs53576 polymorphism on DP/DR symptoms. The study sample consisted of 84 women, including 43 depressed patients and 41 control subjects, aged 19–52. DP/DR symptoms were measured with the Cambridge Depersonalization Scale; unresolved attachment status was assessed with the Adult Attachment Interview. OXTR rs53576 genotypes were obtained from blood samples. We found a highly significant gene–environment interaction: Individuals with unresolved attachment status were significantly more depersonalized when they carried the GG-allele than A-allele carriers than not unresolved subjects. There was no statistically significant main influence of OXTR genotypes or unresolved attachment status on DP/DR symptoms. We suggest that the GG-allele and unresolved attachment status might be considered as risk factors in the etiology of DP/DR symptoms. Replication is needed in larger samples including male subjects.     

Investigating the Links Between Cultural Values and Belief in Conspiracy Theories: The Key Roles of Collectivism and Masculinity

Research suggests that belief in conspiracy theories (CT) stems from basic psychological mechanisms and is linked to other belief systems (e.g., religious beliefs). While previous research has extensively examined individual and contextual variables associated with CT beliefs, it has not yet investigated the role of culture. In the current research, we tested, based on a situated cultural cognition perspective, the extent to which culture predicts CT beliefs. Using Hofstede's model of cultural values, three nation-level analyses of data from 25, 19, and 18 countries using different measures of CT beliefs (Study 1, N = 5323; Study 2a, N = 12,255; Study 2b, N = 30,994) revealed positive associations between masculinity, collectivism, and CT beliefs. A cross-sectional study among U.S. citizens (Study 3, N = 350), using individual-level measures of Hofstede's values, replicated these findings. A meta-analysis of correlations across studies corroborated the presence of positive links between CT beliefs, collectivism, r = .31, 95% CI = [.15; .47], and masculinity, r = .39, 95% CI = [.18; .59]. Our results suggest that in addition to individual differences and contextual variables, cultural factors also play an important role in shaping CT beliefs.     

Disentangling perceptual and response bias in unilateral neglect: a methodological proposal

Bisiach and his colleagues have developed a new version of Milner's "landmark task" for the purpose of separating "perceptual" and "response" biases in neglect patients. Subjects are required to decide which is the longer (or the shorter) of the two portions of a pre-bisected horizontal line. The authors proposed two indices to measure perceptual and response bias respectively. However, these indices are not mathematically independent of one another. Moreover, they do not exploit all of the information available in the data, since they do not consider the effect of the different transection locations across trials. We now propose an alternative means of analyzing data from the revised Landmark task, which generates independent estimates of perceptual and response biases. The method and its theoretical foundation are summarized, and illustrative data obtained from brain damaged patients and control subjects are presented.     

Does grasping in patient D.F. depend on vision?

A recently published study of grasping in patient D.F. challenges the well-known dissociation between vision-for-perception and vision-for-action, suggesting instead that D.F.'s preserved grip scaling depends entirely on haptic feedback. We argue that the results of the study are in fact fully consistent with the perception-action account.     

Gender and Military Contextual Risk Factors for Intimate Partner Aggression

This study explored individual and military risk factors for intimate partner aggression (IPA) perpetration among Navy personnel in their second year of service. We found some evidence that job stress was related to higher perpetration among men. Contrary to expectations, ship duty was related to lower perpetration rates, even though it involves more military operational stress and more frequent deployments than does shore duty. Premilitary alcohol problems were a stronger risk factor for men than for women, whereas premilitary patterns of aggressive behavior were a stronger risk factor for women. Recommendations for future research and public health interventions are discussed.     

Family Environment in Inner-City African-American and Latino Parents/Caregivers: A Comparison of the Reliability of Instruments

Inner-city, African American and Latino youth are at higher risk for the development of obesity and type 2 diabetes. Interventions usually focus on changing physical activity and dietary behaviors, yet family environment has the potential to influence response to these interventions. We aimed to identify instruments that could reliably be used to assess the family environment of children from high-risk populations. Selected indices from four instruments were used; the Family Environment Scale (FES), the Family Adaptability and Cohesion Evaluation Scales IV (FACES IV), the Self-report Family Inventory (SFI), and the Family Assessment Device (FAD). Out of 15 indices evaluated, 9 were reliable in both ethnicities including FES cohesion, conflict and organization, SFI emotional expressiveness, conflict and family health/competence, FACES IV family communication and family satisfaction, and FAD general functioning. Perceived family environment characteristics did not differ significantly for inner-city African American and Hispanic families.