Empirically defined symptom scales using the DISC 2.3

Empirically defined scales of depressive, attention deficit hyperactivity disorder, oppositional-defiant disorder, and conduct symptoms from the lay-administered National Institute of Mental Health (NIMH) Diagnostic Interview Schedule for Children (DISC), version 2.3, and evidence of their reliability and validity, are presented. The scales were developed using factor analyses of data obtained from an epidemiologic survey of over 1,200 children drawn from four sites across the U.S. and Puerto Rico (the NIMH Methods for the Epidemiology of Child and Adolescent Mental Disorders, or MECA Study). Their psychometric properties were tested in a subsample of children reinterviewed by clinicians. The findings support the use of these continuous measures. The scales are strongly related to the diagnostic categories and show good test-retest reliability. The scales can be used to characterize severity in children with diagnoses and to describe problems and symptoms in children without diagnoses. Because these scales can measure gradations in symptomatology, they may be more useful than categorical measures. Like categorical measures, the scales based on the DISC are greatly influenced by the informant, whether child or parent.This research was supported by grant MH-46732 from the National Institute of Mental Health, Bethesda, Maryland.The MECA Program is an epidemiologic methodology study performed by four independent research teams in collaboration with staff of the Division of Clinical Research, which was reorganized in 1992 with components now in the Division of Epidemiology and Services Research and the Division of Clinical and Treatment Research, of the NIMH, Rockville, Maryland. The NIMH Principal Collaborators are Darrel A. Regier, MD, MPH, Ben Z. Locke, MSPH, Peter S. Jensen, MD, William E. Narrow, MD, MPH, and Donald S. Rae, MA; the NIMH Project Officer was William J. Huber. The Principal Investigators and Coinvestigators from the four sites are as follows: Emory University, Atlanta, Georgia, UO1 MH46725: Mina K. Dulcan, MD, Benjamin B. Lahey, PhD, Donna J. Brogan, PhD, Sherryl Goodman, PhD, and Elaine Flagg, PhD; Research Foundation for Mental Hygiene at New York State Psychiatric Institute (Columbia University), New York, New York, UO1 MH46718: Hector R. Bird, MD, David Shaffer, MD, Myrna Weissman, PhD, Patricia Cohen, PhD, Denise Kandel, PhD, Christina Hoven, PhD, Mark Davies, MPH, Madelyn S. Gould, PhD, and Agnes Whitaker, MD; Yale University, New Haven, Connecticut, UO1MH46717: Mary Schwab-Stone, MD, Philip J. Leaf, PhD, Sarah Horwitz, PhD, and Judith H. Lichtman, MPH; University of Puerto Rico, San Juan, Puerto Rico, UO1 MH46732: Glorisa Canino, PhD, Maritza Rubio-Stipec, MA, Milagros Bravo, PhD, Margarita Alegría, PhD, Julio Ribera, PhD, Sarah Huertas, MD, and Michael Woodbury, MD.The authors gratefully acknowledge Zenaida González and José Martínez who performed the data nalayses, as well as Elizabeth Pastrana, and Felícita Laboy, secretaries, for their valuable contributions to this work.     

Raising the IQ: The Ramey and Haskins study

The Ramey and Haskins intervention experiment succeeded in producing IQ gains at three years of age averaging about one standard deviation in young children who were selected for being at risk for subnormal intellectual development. The study is examined in terms of its consistency with other findings, the heritability of IQ, the g aspect of IQ, the simplex pattern of longitudinal interage mental test score correlations, mother-child IQ correlations, and criteria for establishing educationally and socially significant gains in intelligence defined as g rather than as a score on a particular test. Narrow transfer of training from cognitive intervention techniques to IQ test performance in early childhood, rather than enhancement of the g factor itself, is hypothesized as a cause of the typical fadeout of early IQ gains in later childhood.     

Personality and the topography of the conditioned eyelid response

One-hundred and four women were tested on an eyelid conditioning paradigm in a 2 x 2 x 2 factorial design where two levels of US intensity (1 vs 3 p.s.i.) were balanced against two rest pause interpolations (after 25 and after 50 trials), and the presence or absence of a warning stimulus prior to CS-US presentation. Subjects were later classified as high, low or intermediate extraverts on the basis of a personality questionnaire. A very detailed analysis of conditioned responses was carried out, using both simple and composite measures including work-ratio, utility-ratio, CR frequency, peak latency, peak amplitude, response area and effective response area, degree of avoidance amplitude and latency, etc. Major findings related to similar effects of high intensity US vs low intensity US, and introversion vs extraversion; introverts react as if they were responding to more intense stimuli than extraverts. This finding cuts across other parameter variables, and supports Eysenck's formulation of personality-conditioning relationships in terms of higher cortical arousal in introverts as compared with extraverts.     

The influence of psychoticism and extraversion on classical eyelid conditioning using a paraorbital shock UCS

An experiment is described in which the effects of Psychoticism and Extraversion on classical eyelid conditioning were examined using a balanced design involving two levels of paraorbital shock intensity and two levels of response threshold. Questionnaire measures of Anxiety and Impulsivity were also analysed together with subjective ratings of the UCS. Results were broadly consistent with Eysenck's personality theory in that subjects scoring high on Psychoticism demonstrated lower levels of conditioning.     

Peer support telephone dyads for elderly women: Was this the wrong intervention?

Tested a preventive intervention in which peer telephone dyads were developed for low-income, community-living, elderly women with low perceived social support. After an initial assessment, respondents were randomly assigned to either an assessment-only control or received 10 weeks of friendly staff telephone contact. After a second assessment, participants receiving the staff contact were randomly assigned to continue that contact or were paired in dyads to continue phone contact with one another. Dependent variables were measures of perceived social support, morale, depression, and loneliness. All groups, particularly the staff contact group, showed some improvement in mental health scores over time, but there were no significant differences between intervention groups, or between intervention and assessment-only control groups. The results suggest that participation in the study and in personal assessment interviews at home were probably morale enhancing, and that additional telephone contact did not significantly add to that effect. Evidence also indicates that, in this sample, low perceived family support was significantly related to poor mental health, so it is possible that a program designed to increase friend support may have been the wrong intervention.     

Changes in depressive-symptom experiences among older women.

Changes in depressive-symptom experiences over a 5-year period were investigated in a community sample of 251 women between the ages of 51 and 92 years. Findings from a confirmatory factor analysis of the SCL-90-R Depression and Additional Symptoms scales (Derogatis, 1983) indicate that two phenomenally different syndromes underlie symptom-reporting patterns. A depressive syndrome, more classic in form, shows decreasing levels with increasing age, although a depletion syndrome, marked by feelings of enervation and a loss of interest in things, shows increasing levels with advancing age. The relative independence of the two syndromes, as well as their differing relations to four more delimited forms of distress that were identified in the analyses, have important implications for future research on the age-depression relation.     

Human classical conditioning

Recent reports of failure to obtain blocking in human galvanic skin response (GSR) conditioning, together with our own equivocal results with eyelid conditioning, have motivated us to re-examine the status of the conditioned stimulus (CS) in human conditioning studies. The issues raised by compound stimuli, by contextual cues and occasion setting stimuli, and by cross-modal transfer are considered in the light of data from our laboratories. These data include observations on the interchangeability of stimulus modalities during acquisition, the use of varying information loads embedded in occasion setting displays, the comparison of alternative blocking designs and the analysis of response topography in relation to stimulus variability. They suggested that an adequate account of the CS in human conditioning studies must recognize that it is dynamically processed and reprocessed both during and after acquisition.