Molecular and behavioral changes associated with adult hippocampus-specific SynGAP1 knockout

The synaptic Ras/Rap-GTPase-activating protein (SynGAP1) plays a unique role in regulating specific downstream intracellular events in response to N-methyl-D-aspartate receptor (NMDAR) activation. Constitutive heterozygous loss of SynGAP1 disrupts NMDAR-mediated physiological and behavioral processes, but the disruptions might be of developmental origin. Therefore, the precise role of SynGAP1 in the adult brain, including its relative functional significance within specific brain regions, remains unexplored. The present study constitutes the first attempt in achieving adult hippocampal-specific SynGAP1 knockout using the Cre/loxP approach. Here, we report that this manipulation led to a significant numerical increase in both small and large GluA1 and NR1 immunoreactive clusters, many of which were non-opposed to presynaptic terminals. In parallel, the observed marked decline in the amplitude of spontaneous excitatory currents (sEPSCs) and inter-event intervals supported the impression that SynGAP1 loss might facilitate the accumulation of extrasynaptic glutamatergic receptors. In addition, SynGAP1-mediated signaling appears to be critical for the proper integration and survival of newborn neurons. The manipulation impaired reversal learning in the probe test of the water maze and induced a delay-dependent impairment in spatial recognition memory. It did not significantly affect anxiety or reference memory acquisition but induced a substantial elevation in spontaneous locomotor activity in the open field test. Thus, the present study demonstrates the functional significance of SynGAP1 signaling in the adult brain by capturing several changes that are dependent on NMDAR and hippocampal integrity.     

Analysing user's reactions in advice-giving dialogues with a socially intelligent ECA

In this paper, we investigate the user's reactions to received suggestion by an Embodied Conversational Agent playing the role of artificial therapist in the healthy eating domain. Specifically, we analyse the behaviour of people who voluntarily requested to receive information from the agent, and we compare it with the results of a previous evaluation experiment in which subjects were not properly motivated to interact with the agent because they were selected for evaluating the system. This study is part of an ongoing research aimed at developing an intelligent virtual agent that applies natural argumentation techniques to persuade the users to improve their eating habits.     

Successes and failures in producing attentional object-based cueing effects

Over 30?years of research using Posner's spatial cueing paradigm has shown that selective attention operates on representations of spatial locations, leading to space-based theories of attention. Manipulations of stimuli and methods have shown this paradigm to be sensitive to several types of object-based representations-providing evidence for theories incorporating object-based attentional selection. This paper critically evaluates the evidence demanding object-based explanations that go beyond positing spatial representations alone, with an emphasis on identifying and interpreting successes and failures in obtaining object-based cueing effects. This overview of current evidence is used to generate hypotheses regarding critical factors in the emergence and influence of object representations-their generation, strength, and maintenance-in the modulation of object-based facilitatory and inhibitory cueing effects.     

The activation of alternative response candidates: When do doubts kick in?

In the current study, we investigated at which moment during visual object categorization alternative interpretations are most strongly activated. According to an early activation account, we are uncertain about how to interpret the visual information early in the categorization process. This uncertainty will vanish over time and therefore, the number of possible response candidates decreases over time. According to a late activation account, the visual information is categorized quickly, but after extensive viewing alternative interpretations become more strongly activated. Therefore, the number of possible response candidates increases over time. To increase perceptual uncertainty we used morphed figures composed of a dominant and nondominant object. The similarity rating between morphed figures and their nondominant object was taken as indicator for the activation of the nondominant response candidate: high similarity indicates that the nondominant object is relatively strongly activated as an alternative response candidate. Presentation times were varied in order to distinguish between the early and late activation account. Using a Bayesian model selection approach, we found support for the late activation account, but not for the early activation account. It thus seems that in a late stage of the categorization process the influence of the nondominant response candidate is strongest.     

Mutual touch during mother–infant face-to-face still-face interactions: Influences of interaction period and infant birth status

Contact behaviours such as touch, have been shown to be influential channels of nonverbal communication between mothers and infants. While existing research has examined the communicative roles of maternal or infant touch in isolation, mutual touch, whereby touching behaviours occur simultaneously between mothers and their infants, has yet to be examined. The present study was designed to investigate mutual touch during face-to-face interactions between mothers and their 5½-month-old fullterm (n = 40), very low birth weight/preterm (VLBW/preterm; n = 40) infants, and infants at psychosocial risk (n = 41). Objectives were to examine: (1) how the quantitative and qualitative aspects of touch employed by mothers and their infants varied across the normal periods of the still-face (SF) procedure, and (2) how these were associated with risk status. Mutual touch was systematically coded using the mother–infant touch scale. Interactions were found to largely consist of mutual touch and one-sided touch plus movement, highlighting that active touching is pervasive during mother–infant interactions. Consistent with the literature, while the SF period did not negatively affect the amount of mutual touch engaged in for mothers and their fullterm infants and mothers and their infants at psychosocial risk, it did for mothers and their VLBW/preterm infants. Together, results illuminate how both mothers and infants participate in shaping and co-regulating their interactions through the use of touch and underscore the contribution of examining the influence of birth status on mutual touch.     

Teaching Ethical Decision Making: Helping Students Reconcile Personal and Professional Values

Because conflicts between personal and professional values can interfere with ethical decision making, a goal of counselor education must be helping students reconcile such conflicts. This article describes one counselor educator's experience teaching ethical decision making and the effects on student learning. Growth was observed in increased tolerance for ambiguity, awareness of how values influenced decision making, use of multiple factors in decision making, and emphasis on the welfare of clients. Implications for teaching and future research directions are discussed.     

Human–Grey parrot (Psittacus erithacus) reciprocity: a follow-up study

In a previous study (Péron et al. in Anim Cogn, doi:10.1007/s10071-012.05640, 2012), Grey parrots, working in dyads, took turns choosing one of four differently coloured cups with differing outcomes: empty (null, non-rewarding), selfish (keeping reward for oneself), share (sharing a divisible reward), or giving (donating reward to other). When the dyads involved three humans with different specific intentions (selfish, giving, or copying the bird’s behaviour), birds’ responses only tended towards consistency with human behaviour. Our dominant bird was willing to share a reward with a human who was willing to give up her reward, was selfish with the selfish human, and tended towards sharing with the copycat human; our subordinate bird tended slightly towards increased sharing with the generous human and selfishness with the selfish human, but did not clearly mirror the behaviour of the copycat. We theorized that the birds’ inability to understand the copycat condition fully—that they could potentially maximize reward by choosing to share—was a consequence of their viewing the copycat’s behaviour as erratic compared with the consistently selfish or giving humans and thus not realizing that they were indeed being mirrored. We suggested that copycat trials subsequently be performed as a separate experiment, without being contrasted with trials in which humans acted consistently, in order to determine if results might have differed. We have now performed that experiment, and shown that at least one Grey parrot—our dominant—responded in a manner suggesting that he deduced the appropriate contingencies.     

Challenging tasks: The role of employees' and supervisors' goal orientations

Research shows that challenging jobs stimulate employee learning and retention. Nevertheless, empirical knowledge on what influences the amount of challenging tasks employees perform in their job is lacking. In this study, we examined the extent to which the performance of challenging tasks is related to employees' and supervisors' goal orientations. We found a positive relationship between employees' mastery-approach orientation and the performance of challenging tasks. Furthermore, if supervisors had authority over the tasks of their employees, supervisors' goal orientations were related to employees' task challenge. Performing challenging tasks was negatively related to supervisors' performance-approach orientation and positively related to supervisors' performance-avoidance orientation.