Religiosity and treatment response to antidepressant medication: a prospective multi-site clinical trial

The present study examined the relationship between religiosity/spirituality and treatment response to antidepressant medication (citalopram). One-hundred and forty-eight Caucasian and African-American adults with uncomplicated major depression were treated with citalopram (20–60?mg/day) over an eight-week period in a prospective multi-site clinical trial. Treatment response was assessed weekly with the Hamilton Rating Scale for Depression. Religiosity (i.e., religious behaviours) and spirituality (i.e., spiritual well-being) were assessed at week 3. No significant associations between spirituality and treatment response were found; however, there was a strong curvilinear relationship between religiosity and treatment response. Compared to lower or higher levels of religiosity, a moderate level of religiosity was significantly associated with a higher likelihood of remission and greater reduction in severity of depression. This association was independent of social support, ethnicity, gender, education, and baseline depression severity. A moderate amount of religiosity appears to be independently associated with an enhanced treatment response to citalopram.     

Why a Big Mac Is a Good Mac: Associations between Affect and Size

Evaluation is a core topic of interest in both social psychology and linguistic theory, but there are relatively few social-cognitive studies examining the “online” consequences of affective metaphor. The experiments presented here sought to investigate such online consequences in relation to an understudied class of metaphors linking evaluation to size (i.e., “bigger is better”). Consistent with such metaphors, we found that positive (vs. negative) words were evaluated more quickly (Experiment 1) and accurately (Experiment 2) when presented in a larger (vs. smaller) font size. Parallel and opposite effects were found for negative words. A third experiment demonstrated that words presented in a larger font size were evaluated more favorably, thus extending size effects to evaluative judgments. Together, the studies converge on the importance of size metaphors for understanding evaluation from a social-cognitive perspective.     

When do children overestimate their knowledge of unfamiliar targets?

We report four investigations in which 5 to 7 year olds judged whether or not they knew familiar- and unfamiliar-named targets. Under some conditions judgments were made in relation to performance on a relevant task, e.g., children judged whether they knew the picture they had picked from a set was the target. Under other conditions, children judged their state of knowledge not in relation to performance, e.g., they answered "Do you know who (target) is?" Under both types of condition, children nearly always made correct "know" judgments when targets were familiar. Correct "don't know" judgments about unfamiliar targets were relatively common when judgments were not made in relation to performance on a task (average scores 80-90% correct), but were less frequent when knowledge was judged in relation to performance on a task (average scores 40-70% correct). Knowledge judged in relation to performance was overestimated even when children did not choose the picture they thought might be the target before making their judgment, when the pictures were face-down, and when children predicted performance on a task not yet present. It seems that although children can make relatively accurate judgments of their own knowledge states, they tend to overestimate their competence when assessing their knowledge in relation to performance on a task. We discuss why this might be.     

Sex differences in the effects of gonadectomy on amphetamine-induced rotational behavior in rats

The effects of gonadectomy on amphetamine-induced rotational behavior were studied in male and female rats. Different systemic doses were used to produce equivalent brain concentrations of the drug in each group, thereby controlling for sex differences in the metabolism of amphetamine. Ovariectomy of female rats significantly attenuated amphetamine-induced rotation, whereas castration of males was without effect. The results support the idea that in females, the endogenous gonadal hormones facilitate functional activity in the mesostriatal dopamine system.     

Book reviews

The Popularization of Medicine 1650–1850 Roy Porter (ed.), 1992 London, Routledge pp. x + 296, £50 (hardback) ISBN 0415 07217 4

Quantum Mechanics: An Empiricist View Bas Van Fraassen, 1991 Clarendon Press, Oxford pp. 558, £17.50 (paperback), ISBN 019 8239807     

We Believe in Being Honest: Examining Subcultural Differences in the Acceptability of Deception1

Perceptions of lie acceptability vary as a function of the motivation for the lie, the relationship between deceiver and deceived, and the perceiver's cultural background. The current study examines the relation between one cultural background—that is, the Church of Jesus Christ of Latter‐Day Saints (LDS)—and perceptions of lie acceptability, and whether this varies as a function of lie and rater characteristics. Participants rated lie acceptability in 12 scenarios varying lie motivation and lie recipient. Overall, the LDS group rated lies as less acceptable than did the non‐LDS group, and lie acceptability varied according to lie motivation and lie recipient. Participant age was negatively correlated with lie acceptability. Implications of the findings and directions for future research are discussed.     

Executive functions in children with Autism Spectrum Disorders

Executive dysfunction is a characteristic impairment of individuals with Autism Spectrum Disorders (ASD). However whether such deficits are related to autism per se, or to associated intellectual disability is unclear. This paper examines executive functions in a group of children with ASD (N = 54, all IQ?70) in relation to a typically developing control group individually matched on the basis of age, gender, IQ and vocabulary. Significant impairments in the inhibition of prepotent responses (Stroop, Junior Hayling Test) and planning (Tower of London) were reported for children with ASD, with preserved performance for mental flexibility (Wisconsin Card Sorting Task) and generativity (Verbal Fluency). Atypical age-related patterns of performance were reported on tasks tapping response inhibition and self-monitoring for children with ASD compared to controls. The disparity between these and previous research findings are discussed. A multidimensional notion of executive functions is proposed, with difficulties in planning, the inhibition of prepotent responses and self-monitoring reflecting characteristic features of ASD that are independent of IQ and verbal ability, and relatively stable across the childhood years.     

Accumulated reinforcers increase academic responding and suppress problem behavior for students with Attention‐Deficit Hyperactivity Disorder

We compared rates of academic responses and problem behavior during mathematics with distributed and accumulated reinforcer arrangements for 3 students with Attention‐Deficit Hyperactivity Disorder who engaged in chronic, severe problem behavior. All 3 students engaged in more academic responding and less problem behavior when reinforcers accumulated throughout the session, relative to conditions in which reinforcers were distributed throughout the session or withheld completely. We then conducted concurrent‐chain analyses to evaluate student preference for the reinforcer arrangements. Two students preferred distributed reinforcers, even though this arrangement continued to produce problem behavior. One student preferred accumulated reinforcers. Our data replicate previous findings regarding the efficacy of accumulated‐reinforcer arrangements, but suggest that students do not always prefer the most efficacious reinforcer arrangement.