Religiosity and treatment response to antidepressant medication: a prospective multi-site clinical trial

The present study examined the relationship between religiosity/spirituality and treatment response to antidepressant medication (citalopram). One-hundred and forty-eight Caucasian and African-American adults with uncomplicated major depression were treated with citalopram (20–60?mg/day) over an eight-week period in a prospective multi-site clinical trial. Treatment response was assessed weekly with the Hamilton Rating Scale for Depression. Religiosity (i.e., religious behaviours) and spirituality (i.e., spiritual well-being) were assessed at week 3. No significant associations between spirituality and treatment response were found; however, there was a strong curvilinear relationship between religiosity and treatment response. Compared to lower or higher levels of religiosity, a moderate level of religiosity was significantly associated with a higher likelihood of remission and greater reduction in severity of depression. This association was independent of social support, ethnicity, gender, education, and baseline depression severity. A moderate amount of religiosity appears to be independently associated with an enhanced treatment response to citalopram.     

Crying threshold and intensity in major depressive disorder

Clinical lore suggests that depression is associated with frequent and intense crying. To test these postulations empirically, a standardized cry-evoking stimulus was presented to depressed and nondepressed participants, and their likelihood of crying and the magnitude of crying-related changes in their emotion experience, behavior, and autonomic physiology were compared. Unexpectedly, crying was no more likely in depressed than in nondepressed participants. Within the nondepressed group, participants who cried exhibited increases in the report and display of sadness and had greater cardiac and electrodermal activation than did participants who did not cry. There was less evidence of this crying-related emotional activation within the depressed group. The lack of emotional activation among clinically depressed participants who cried provides a tantalizing clue concerning how emotions are dysregulated in this disorder.     

Loving-kindness meditation increases social connectedness

The need for social connection is a fundamental human motive, and it is increasingly clear that feeling socially connected confers mental and physical health benefits. However, in many cultures, societal changes are leading to growing social distrust and alienation. Can feelings of social connection and positivity toward others be increased? Is it possible to self-generate these feelings? In this study, the authors used a brief loving-kindness meditation exercise to examine whether social connection could be created toward strangers in a controlled laboratory context. Compared with a closely matched control task, even just a few minutes of loving-kindness meditation increased feelings of social connection and positivity toward novel individuals on both explicit and implicit levels. These results suggest that this easily implemented technique may help to increase positive social emotions and decrease social isolation.     

An examination of the relation of individual difference variables to loneliness

This study investigated the relation of five individual difference variables (extroversion, depression, self-esteem, neuroticism, and attitude toward others) to loneliness. The relative contributions of two different models that might explain these relations were examined. One model suggests that individual difference variables are related to loneliness through the mediation of social network variables; that is, individual difference variables may reduce people's motivation and/or ability to build and maintain social relationships, which in turn leads to loneliness. The second model, the cognitive bias model, states that both the individual difference variables and loneliness are influenced by the same intrapersonal, cognitive processes. Some people are prone to negative affect and tend to evaluate themselves and their relationships negatively. The relations of self-esteem, neuroticism, and depression to loneliness were hypothesized to reflect the cognitive bias model, while extroversion and attitudes toward others were hypothesized to be related to loneliness through the mediation of social network variables. Eighty-two female and 42 male adults completed measures of loneliness and the five individual difference variables, as well as an instrument assessing their social networks. The results indicated partial support for both models for each of the individual difference variables. Together, the two models did a good job of explaining the correlations of the individual difference variables and loneliness. The implications of these findings, as well as their relation to previous research, are discussed.     

Measuring the stop point of rapid smoking

A method and an apparatus are described for measuring the point at which subjects elect to stop smoking when cigarette smoke is delivered more rapidly than in typical smoking. The device allows either the subject or the experimenter to control the volume of smoke and the interval between puffs. The device delivers reliable quantities of particulate matter from cigarette smoke. Subjects retested a week apart exhibited consistent stopping points.     

Social processing errors among paranoid personalities

The present study tested clinical hypotheses about the social processing attributes of paranoid personalities (PP). Eighteen PPs and 18 normal controls (NC) viewed standardized role plays (Dodge, 1986) in which a provocation occurred but the protagonist's intention varied (i.e., ambiguous, accidental, hostile, or prosocial). Subjects identified the intention behind the action and then chose a response to that action (e.g., ignore what he did). The results indicated that PPs and NCs did not differ on intentioncue detection when the intention was clear, but PPs had a significantly higher rate of misreading ambiguous situations. Furthermore, when intentions were ambiguous, PPs were more likely than NCs to identify them as hostile intentions. Finally, PPs' reactions to the vignettes were different from normal controls' when the perceived intention was either prosocial or accidential. PPs were more likely to respond with anger and less likely to ignore the event, compared to NCs. These data provide initial support for clinical notions about the aberrant social processing of paranoid personalities.