Views of Genetics Health Professionals on the Return of Genomic Results

As exome and whole genome sequencing become clinically available, the potential to receive a large number of clinically relevant but incidental results is a significant challenge in the provision of genomic counseling. We conducted three focus groups of a total of 35 individuals who were members of ASHG and/or NSGC, assessing views towards the return of genomic results. Participants stressed that patient autonomy was primary. There was consensus that a mechanism to return results to the healthcare provider, rather than patient, and to streamline integration into the electronic health record would ensure these results had the maximal impact on patient management. All three focus groups agreed that pharmacogenomic results were reasonable to return and that they were not felt to be stigmatizing. With regard to the return of medically relevant results, there was much debate. Participants had difficulty in consistently assigning specific diseases to ‘bins’ that were considered obligatory versus optional for disclosure. Consensus was reached regarding the importance of informed consent and pretest counseling visits to clarify what the return of results process would entail. Evidence based professional guidelines should continue to be developed and regularly revised to assist in consistently and appropriately providing genomic results to patients.     

Commission errors but not critical lures decrease when you have to pay a price for them

Using the Deese-Roediger-McDermott paradigm, we explored the effect of monetary penalty on false memories. Participants were presented 6 15-word lists of semantic associates that all converged on a nonpresented critical lure. Next, half of the participants received a monetary reward (0.10 Euro; about $0.10) for each correctly recalled word, whereas they lost money (0.20 Euro; about $0.20) for each incorrect response. Compared with control participants who received a fixed financial compensation, participants in the experimental group reported fewer commissions (i.e., incorrect responses other than the critical lure). Number of hits and critical lures did not differ between the groups.     

Saving Bulgaria's Jews: an analysis of social identity and the mobilisation of social solidarity

This paper investigates the arguments used in public documents to mobilise Bulgarians against the deportation of Jews in World War II. We focus on the key documents relating to the first wave of mobilisation in 1940–1941 as provided by Todorov in The Fragility of Goodness ( 2001 ). We demonstrate that these documents are based on three types of argument. The first, category inclusion, treats the Jews as part of a common ingroup rather than as constituting a separate outgroup. The second, category norms, proposes that help for those under attack is a core aspect of ingroup identity. The third, category interest, suggests that the ingroup will be harmed if Jews are persecuted. In each case, the predominant category on which arguments are based is national identity (i.e. ‘we Bulgarians …’). This analysis is used to validate and extend a social identity of model of helping. The theoretical and practical implications of such an approach are considered in the discussion. Copyright © 2006 John Wiley & Sons, Ltd.     

Naturalistic Decision-Making Task Processes in Multiprofessional Assessment of Disability

Evaluation of preschool children with complex disabilities is regarded as a group decision-making process. This process was studied in two tertiary-level multiprofessional groups in London, UK: one based in a neurodisability center and one organized by a school psychological service. The assessment discussions about two preschool children at each site were audio recorded. Each assessment was carried out over half a day by all the professionals simultaneously with the family. Postassessment interviews were held with each professional and family. Verbal protocol analysis captured the structure of each assessment through six TASK decision-making processes applied at three levels of reasoning and decision making. Sequential application of processes was found to be influenced by the occurrence of a series of three cycles of decision making within each assessment and the decomposition of the assessment task into distinct subproblems.     

Measuring and modeling salience with the theory of visual attention

For almost three decades, the theory of visual attention (TVA) has been successful in mathematically describing and explaining a wide variety of phenomena in visual selection and recognition with high quantitative precision. Interestingly, the influence of feature contrast on attention has been included in TVA only recently, although it has been extensively studied outside the TVA framework. The present approach further develops this extension of TVA’s scope by measuring and modeling salience. An empirical measure of salience is achieved by linking different (orientation and luminance) contrasts to a TVA parameter. In the modeling part, the function relating feature contrasts to salience is described mathematically and tested against alternatives by Bayesian model comparison. This model comparison reveals that the power function is an appropriate model of salience growth in the dimensions of orientation and luminance contrast. Furthermore, if contrasts from the two dimensions are combined, salience adds up additively.     

Index to Volume 28

Other Index

Index to Volume 28