Proper bootstrapping

According to a much discussed argument, reliabilism is defective for making knowledge too easy to come by. In a recent paper, Weisberg aims to show that this argument relies on a type of reasoning that is rejectable on independent grounds. We argue that the blanket rejection that Weisberg recommends of this type of reasoning is both unwarranted and unwelcome. Drawing on an older discussion in the philosophy of science, we show that placing some relatively modest restrictions on the said type of reasoning suffices to block the anti-reliabilist argument.     

Oxidative stress in university students during examinations

Mental stress in psychiatric disease and in daily life contributes to oxidative stress in the body. In this study we investigated a connection between possible psychological stress caused by university undergraduate examinations and oxidative stress experienced by our test subjects. Some parameters of oxidative stress (single strand breaks of DNA in lymphocytes, sensitivity to lipid oxidation and antioxidant status) were studied in medical students on the day of the examination (stress condition) and compared with the same parameters obtained from the same students during the term between two examination periods (non-stress condition). The results show that in the stress condition oxidative damage to DNA and sensitivity to lipid oxidation were significantly increased (p<0.05) when compared with the same parameters in "non-stress" conditions. A significant decrease in plasma antioxidant activity (p<0.05) in students that were under stress was observed. These results suggest that during university examinations students are under increased oxidative stress.     

Haptics and projection: drawings by Tracy, a blind adult

Outline drawings in a raised form were made by a blind woman, Tracy, who has been blind from very early in life. Highly practiced in drawing, she reports she is largely self-taught. To invoke matters of projection, she was asked to represent an object with faces slanting away from the observer, a fixed array from different vantage points, and sets of objects in depth. In particular, she drew a cube balanced on a vertex, three objects from different vantage points, receding rows of glasses, and a house. Her drawings included features of parallel and polar projection. Her use of these features may reflect an appreciation of direction from a vantage point, which observers deal with via haptics in everyday tasks. Tracy may have advanced drawing-development skills common to the blind and the sighted.     

Neurocognitive Complications of HIV Disease

Neurocognitive complications are the most common sequelae of HIV infection if the full spectrum of HIV disease—from initial seroconversion to death from advanced AIDS—is considered. Though resembling subcortical neurological disorders from a neuropsychological standpoint, the presentation is variable, and almost any pattern can be seen. Although neuropsychological impairment is often subtle, it can affect day-to-day life and is associated with earlier mortality. It is not clear if milder forms of neurocognitive disturbance necessarily presage advanced dementia, and current data suggest a two-factor model: a subacute relapsing-remitting condition that can occur at any stage of HIV disease and a progressive, more fulminant dementia. The pathological substrates of these conditions are not well characterized, although recent data support the notion that synaptodendritic damage underlies the neuropsychological impairment, and may precede the neuronal loss and other pathological features more characteristic of HIV encephalitis. Some reversibility of neurocognitive disturbance has been reported with zidovudine therapy, though the data are not consistent. New regimens involving protease inhibitors need to be evaluated in terms of benefit to the central nervous system because many drugs of this class do not penetrate the blood-brain barrier efficiently. Finally, studies utilizing experimental treatments that may affect the putative mechanisms of neural injury are in progress.     

Lambek Calculus with Conjugates

Studia Logica - We study an expansion of the Distributive Non-associative Lambek Calculus with conjugates of the Lambek product operator and residuals of those conjugates. The resulting logic is...