Modeling possible effects of atypical cerebellar processing on eyeblink conditioning in autism

Autism is unique among other disorders in that acquisition of conditioned eyeblink responses is enhanced in children, occurring in a fraction of the trials required for control participants. The timing of learned responses is, however, atypical. Two animal models of autism display a similar phenotype. Researchers have hypothesized that these differences in conditioning reflect cerebellar abnormalities. The present study used computer simulations of the cerebellar cortex, including inhibition by the molecular layer interneurons, to more closely examine whether atypical cerebellar processing can account for faster conditioning in individuals with autism. In particular, the effects of inhibitory levels on delay eyeblink conditioning were simulated, as were the effects of learning-related synaptic changes at either parallel fibers or ascending branch synapses from granule cells to Purkinje cells. Results from these simulations predict that whether molecular layer inhibition results in an enhancement or an impairment of acquisition, or changes in timing, may depend on (1) the sources of inhibition, (2) the levels of inhibition, and (3) the locations of learning-related changes (parallel vs. ascending branch synapses). Overall, the simulations predict that a disruption in the balance or an overall increase of inhibition within the cerebellar cortex may contribute to atypical eyeblink conditioning in children with autism and in animal models of autism.     

Thomas Aquinas Holds Fast: Objections to Aquinas within Today's Debate on Divine Action

Various authors within the contemporary debate on divine action in nature and contemporary science argue both for and against a Thomistic account of divine action through the notions of primary and secondary causes. In this paper I argue that those who support a Thomistic account of divine action often fail to explain Aquinas' doctrine in full, while those who argue against it base their objections on an incomplete knowledge of this doctrine, or identify it with Austin Farrer's doctrine of double agency – again failing to do Aquinas justice. I analyse these objections, indicating how they do not address Aquinas' doctrine by offering a brief but full account of the latter.     

Marcos de referencia en el estudio de los mapas cognitivos de ambientes urbanos

Resumen

El presente artículo ofrece una revisión de los estudios realizados en las dos últimas décadas sobre mapas cognitivos aplicados al mundo urbano a partir de las investigaciones llevadas a cabo por los autores de primera línea en el tema. El conjunto de tales trabajos hace patente la falta de articulación en que se encuentra el constructo «mapa cognitivo». Sin embargo, ofrecen unas orientaciones a tener en cuenta necesariamente en cualquier futura investigación.     

Die Atomistik bei Ludwig Boltzmann. Zur wissenschaftlichen und philosophischen Bedeutung einer kontroversen Position am Ende des 19. Jahrhunderts

The atomic hypothesis according to Ludwig Boltzmann. The scientific and philosophical importance of a controversial position at the close of the 19th century. This paper examines Boltzmann’s standpoint in the controversy over the existence of atoms between himself on the one hand and Mach, Ostwald, Helm and to some extent Duhem on the other hand. The latter wanted to develop a physics only constructed with perceptible phenomena. Because of the lack of empirical evidence of the atoms at that time they did not accept them for the construction of physics. In contrast, Boltzmann found the acceptance of atoms to be a fruitful assumption, since for him the construction of physics required going beyond perceptible phenomena. Two different conceptions of nature and of the ways to know nature clashed in this disagreement between Boltzmann and his opponents. Op-posing one-sided positions, Boltzmann supported the hypothetical character of science, in which more than one basic hypothesis can be advanced: he was open to the possibility of fundamental revolutions in science.

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Die Atomistik bei Ludwig Boltzmann. Zur wissenschaftlichen und philosophischen Bedeutung einer kontroversen Position am Ende des 19. Jahrhunderts

     

Auditory categorization of complex sounds by rats (Rattus norvegicus)

Little research has explored the auditory categorization abilities of mammals. To better understand these processes, the authors tested the abilities of rats (Rattus norvegicus) to categorize multidimensional acoustic stimuli by using a classic category-learning task developed by R. N. Shepard, C. I. Hovland, and H. M. Jenkins (1961). Rats proved to be able to categorize 8 complex sounds on the basis of either the direction or rate of frequency modulation but not on the basis of the range of frequency modulation. Rats' categorization abilities were limited but improved slowly and incrementally, suggesting that learning was not facilitated by selective attention to acoustic dimensions.     

Personality,amphetamine and intracranial self-stimulation in rats

The relationship between open-field ambulation and intracranial self-stimulation (ICSS) at the lateral hypothalamic area was studied in rats. A treatment with i.p. saline of d-amphetamine was also applied to the animals prior to ICSS tests. High-ambulatory rats (comparable to human extraverts) showed an equally higher susceptibility to ICSS reward than low-ambulatory rats (comparable to human introverts) with both saline and amphetamine. These findings were interpreted comsidering the ICSS as a strong stimulation which would tend to produce ‘unconditioned inhibition’ much earlier in low-ambulatory rats than high-ambulatory rats thus leading to a better conditioning among the high-ambulatory Ss.     

Memory for stereotype-related material–a replication study with real-life social groups

This paper reports a study comparing the memorability of information that either confirmed, disconfirmed, or was irrelevant to, particular real-life social group stereotypes. Memory for both stereotype-confirming and stereotype-disconfirming material was enhanced relative to that for material which was stereotype-irrelevant. Further, there were no differences between the memory for stereotype-confirming and -disconfirming information. Implications for stereotype stability and change are noted.     

CEREBRAL ASYMMETRY AND COGNITIVE DEVELOPMENT IN CHILDREN:

Abstract— Phonemic awareness, the ability to abstract and manipulate auditory symbols, is a distinguishing human characteristic Neurobiological specializations in the left hemisphere and cultural exposure to language interact to shape development of this ability Modern imaging techniques now permit investigation of the interaction of these forces In this initial cross-sectional study, we found evidence for a shift from neurobiological to cultural regulation In young children, aged5 to 9, anatomical asymmetry of the auditory association cortex predicted phonemic awareness In older children, the relationship disappeared, as all children became skilled readers The findings suggest that children with different patterns of cognitive strengths and weaknesses may have different spatiotemporal patterns of cortical development.     

The Self in Movement: Being Identified and Identifying Oneself in the Process of Migration and Asylum Seeking

How migration influences the processes of identity development has been under longstanding scrutiny in the social sciences. Usually, stage models have been suggested, and different strategies for acculturation (e.g., integration, assimilation, separation, and marginalization) have been considered as ways to make sense of the psychological transformations of migrants as a group. On an individual level, however, identity development is a more complex endeavor: Identity does not just develop by itself, but is constructed as an ongoing process. To capture these processes, we will look at different aspects of migration and asylum seeking; for example, the cultural-specific values and expectations of the hosting (European) countries (e.g., as identifier), but also of the arriving individuals/groups (e.g., identified as refugees). Since the two may contradict each other, negotiations between identities claims and identity assignments become necessary. Ways to solve these contradictions are discussed, with a special focus on the experienced (and often missing) agency in different settings upon arrival in a new country. In addition, it will be shown how sudden events (e.g., 9/11, the Charlie Hebdo attack) may challenge identity processes in different ways.