Does performance on the standard antisaccade task meet the co-familiality criterion for an endophenotype?

The “co-familiality” criterion for an endophenotype has two requirements: (1) clinically unaffected relatives as a group should show both a shift in mean performance and an increase in variance compared with controls; (2) performance scores should be heritable. Performance on the antisaccade task is one of several candidate endophenotypes for schizophrenia. In this paper we examine whether the various measures of performance on the standard version of the antisaccade task meet the co-familiality criterion for an endophenotype. The three measures of performance—reflexive saccade errors, latency of correct antisaccades, and gain—show a wide range of effect sizes and variance ratios as well as evidence of significant or near significant heterogeneity. The estimated mean effect sizes [Cohen’s d: error rate: 0.34 (SD: 0.29); latency: 0.33 (SD: 0.30); gain: 0.54 (SD: 0.38)] are significantly greater than 0, but the magnitude of the departures from 0 is relatively small, corresponding to modest effect sizes. The width of the 95% confidence intervals for the estimated effect sizes (error rate: 0.2–0.49; latency: 0.17–0.50; gain: 0.23–0.85) and the coefficients of variation in effect sizes (error rate: 85.3%; latency: 90.9%; gain: 68.4%) reflect heterogeneity in effect sizes. The effect sizes for error rate showed statistically significant heterogeneity and those for latency (P = .07) and gain (P = .09) showed a trend toward heterogeneity. These results indicate that the effect sizes are not consistent with a single mean and that the average effect size may be a biased estimate of the magnitude of differences in performance between relatives of schizophrenics and controls. Relatives of schizophrenics show a small but significant increase in variance in error rate, but the confidence interval is broad, perhaps reflecting the heterogeneity in effect size. The variance ratios for latency and gain did not differ in relatives of schizophrenics and controls. Performance, as measured by error rate, is moderately heritable. The data do not provide compelling support for a consistent shift in mean or variance in relatives of schizophrenia patients compared with nonpsychiatric controls, both of which are required for a major gene involved in co-familial transmission. This set of findings suggests that although intra-familial resemblance in antisaccade performance is due in part to genetic factors, it may not be related to a schizophrenia genotype. Based on the current literature, it would be premature to conclude that any of the measures of antisaccade performance unambiguously meets the co-familiality criterion for an endophenotype.     

Forgotten but not gone: context effects on recognition do not require explicit memory for context

Context effects on recognition memory provide an important indirect assay of associative learning and source memory. Neuropsychological studies have indicated that such context effects may obtain even if the contexts themselves are not remembered--for example, in individuals impaired on direct tests of memory for contextual information. In contrast, a recent study indicated that the effects of temporal context reinstatement on visual recognition obtain only when the contextual information itself was explicitly recollected. Here we report that the effects of reinstatement of spatial-simultaneous context on visual object recognition memory obtain irrespective of whether those context stimuli are explicitly recognized. We suggest that spatial-simultaneous context effects might be based on ensemble unitization of target and context stimuli at encoding, whereas temporal context effects may require recollective processes.     

Expectation-based syntactic comprehension

This paper investigates the role of resource allocation as a source of processing difficulty in human sentence comprehension. The paper proposes a simple information-theoretic characterization of processing difficulty as the work incurred by resource reallocation during parallel, incremental, probabilistic disambiguation in sentence comprehension, and demonstrates its equivalence to the theory of Hale [Hale, J. (2001). A probabilistic Earley parser as a psycholinguistic model. In Proceedings of NAACL (Vol. 2, pp. 159-166)], in which the difficulty of a word is proportional to its surprisal (its negative log-probability) in the context within which it appears. This proposal subsumes and clarifies findings that high-constraint contexts can facilitate lexical processing, and connects these findings to well-known models of parallel constraint-based comprehension. In addition, the theory leads to a number of specific predictions about the role of expectation in syntactic comprehension, including the reversal of locality-based difficulty patterns in syntactically constrained contexts, and conditions under which increased ambiguity facilitates processing. The paper examines a range of established results bearing on these predictions, and shows that they are largely consistent with the surprisal theory.     

Are members of low status groups perceived as bad, or badly off? Egalitarian negative associations and automatic prejudice

Three studies explored the hypothesis that implicit measures of prejudice can tap negative, yet egalitarian associations. In Study 1, automatically associating African Americans with oppression predicted greater automatic prejudice. In Studies 2 and 3, classically conditioning associations between the novel group Noffians and words like oppressed, maltreated, and victimized led to greater automatic prejudice against Noffians. Results suggest that White Americans’ negative automatic associations with African Americans may partly result from associating members of low status groups with unfair circumstances. Because automatic associations predict prejudiced behaviors, the burden of proof is on those wishing to argue that egalitarian negative associations complicate the assessment of automatic attitudes rather than contribute to prejudiced responses. Discussion focuses on the implications of egalitarian negative associations for the theory and measurement of automatic prejudice.     

Can CBT Be Effective for Aboriginal Australians? Perspectives of Aboriginal Practitioners Trained in CBT

The objective of the study was to investigate whether high and low intensity versions of cognitive behaviour therapy (CBT) might be an effective therapeutic approach for enhancing the mental health of Aboriginal Australians. Five university‐educated Aboriginal counsellors received in‐depth training in CBT. Over the following year, they used CBT strategies with their clients, and met 10 times as a participatory action research group. The group addressed three key questions: (a) Does CBT appear to be useful for Aboriginal Australians? (b) If so, what elements of CBT are perceived to be effective? (c) What adaptations might be made to CBT to enhance its effectiveness with Aboriginal Australians? The resulting qualitative data were transcribed and analysed. Counsellors perceived CBT to be very useful for their Aboriginal clients and for themselves. They reported that it enhanced their clients' well‐being, their own clinical skills, and their own well‐being, and it reduced burnout. The qualities of CBT that were perceived to be effective were its adaptability, pragmatic here‐and‐now approach, capacity for low‐intensity interventions, safe containing structure, promotion of self‐agency, and valuable techniques. It was suggested that the prime requirement for adaptations to CBT were that they would need to fit different social and cultural contexts.     

Why do people with an anxiety disorder utilize more nonmental health care than those without?

OBJECTIVE: It is unclear why nonmental healthcare utilization is greater among those with psychological problems. The authors examined healthcare utilization in HMO patients to determine whether greater utilization in anxiety disorder (AD) patients was explained by anxiety symptoms (increasing sensitivity to physical symptoms) or comorbid illness (causing greater need for services). DESIGN: Patients were randomly selected from the database of a multi-specialty practice and 1,041 completed a survey assessing psychological symptoms, health behaviors, and demographics. Anxiety symptoms were assessed by questionnaire and the presence of an AD was determined from the medical chart. Healthcare encounters and medication use were abstracted from medical charts and HMO claims data. MAIN OUTCOME MEASURES: Healthcare utilization. RESULTS: Both AD and anxiety symptoms predicted utilization, but symptoms were not associated with utilization in a model that also included AD. Comorbid illness was significantly associated with utilization independent of AD and somewhat reduced the strength of the AD-utilization association. The results were replicated in comparison of those with any psychiatric disorder to those without. CONCLUSION: Among those with AD, greater utilization is not explained by anxiety symptoms but is partly explained by greater comorbid illness. Further study is needed to understand excess healthcare utilization among AD patients.     

All the Lonely People...Where Do They All Belong?

The author uses humor and fosters empathy in order to establish a fragile group cohesion for five isolated patients at a group analytic training institute. Self-psychological concepts, in particular the alter ego or twinship transference, help explain the profound and painful yearnings of these unlikely group members, whose great need for relatedness was generally trumped by the terror of it. The group's poignant wish for affiliation (somewhat paralleled in the therapist's joining a training program) was similarly impeded by a fear of an aversive affiliation, a fear which for these group members remained understandably powerful after a lifetime of false and failed affiliative starts. The author concludes that it is these lonely people who should be (and can be) served by analytic group work.     

The Main Problem with USC Libertarianism

Libertarians like Robert Kane believe that indeterminism is necessaryfor free will. They think this in part because they hold both (1) thatmy being the ultimate cause of at least part of myself is necessary forfree will and (2) that indeterminism is necessary for this ``ultimateself-causation'. But seductive and intuitive as this ``USCLibertarianism' may sound, it is untenable. In the end, nometaphysically coherent (not to mention empirically valid) conception ofultimate self-causation is available. So the basic intuition motivatingthe USC Libertarian is ultimately impossible to fulfill.     

Hemispheric asymmetries for global and local visual perception: effects of stimulus and task factors.

Although neurotogical and physiological studies indicate a right hemisphere superiority in global processing and a left hemisphere superiority in local processing of Navon-type hierarchical letters (D. Navon, 1977), most investigations of lateralized perception in healthy participants report neither asymmetry. In 6 experiments the authors examined the influence of attentional demands, stimulus properties, and mode of response on perceptual asymmetries for global and local perception. Consistent with their theoretical predictions, asymmetries were more robust on divided- than focused-attention tasks and in response to stimuli in which local and global levels were equally salient compared with those with greater global than local saliency. Contrary to their prediction, perceptual asymmetries were not influenced by the complexity of the motor response.