Accidental germ-line modifications through somatic cell gene therapies: some ethical considerations

Proposed somatic cell gene-therapies (especially those involving in utero therapies) may involve a small risk of germ-line modifications; this risk has engendered serious concern, and arguments have been made that such therapies ought not be pursued if such risks exists. We argue here that while pursuing deliberate germ-line modifications in humans would be inappropriate given the current state of the art, the risk of accidental germ-line modifications from most currently proposed in utero gene therapy is no different in kind or degree from other risks regularly taken in medical procedures. Given the possible benefits of such therapies, we argue that the risk of accidental germ-line modifications is well worth taking in these cases.     

Assessing the Experience of Autonomy in New Cultures and Contexts

This research demonstrates the usefulness of the technique of Smallest Space Analysis (SSA) in the construction of indices of the experience of autonomy, a central construct in Ryan and Deci’s self-determination theory of motivation and personality (SDT, 2000) and a construct central to recent controversies on socialization in different cultures. We propose that SSA has two advantages in comparison to correlation tables in the assessment of the experience of autonomy. First, it allows easy identification of items that best capture the various motivations along the relative autonomy continuum postulated by SDT. Second, and more important, it can reveal data patterns that might contribute to theoretical refinement that otherwise might remain unnoticed. These advantages were demonstrated in three Israeli samples: two samples of elementary school children (n = 697 and n = 417), and one sample of high school students (n = 317). Discussion considers ways in which SSA can contribute to the development and refinement of measures and theory pertaining to the experience of autonomy in cultures and contexts not examined so far.

Psychopathology in mothers of children with failure to thrive

An association between maternal psychopathology and failure to thrive (FTT) has been reported previously, but no prior investigators have used both operationalized diagnostic criteria for psychopathology and a control group in their studies. Twenty-eight mothers of children with FTT and 22 mothers of normally developing control children were assessed for psychopathology by the Structured Clinical Interview for DSM-III-R–Nonpatient Version (SCID-NP) and the Structured Clinical Interview for DSM-III-R–Personality Disorders (SCID-II). Affective disorders, personality disorders, and the COoccurrence in an indvidual of these two types of disorders were found at higher rates in mothers of children with FTT compared to controls. These results clarify prior reports of an association between failure to thrive and maternal psychopathology and may have implications for treatment approaches to FTT.     

A PSYCHOBIOLOGICAL REVIEW OF DEPRESSION DURING PREGNANCY

This paper argues that depression may be viewed as one of several normal affective developments of pregnancy rooted in some of the physiological events of gestation and that identification of depression during pregnancy may be difficult (but nonetheless important) because the symptoms of pregnancy and depression are confounded. Studies are reviewed that suggest variations in the incidence and course of depression during pregnancy, some biological bases for such depression when it occurs, some systems through which it might operate, and the possible need for biological and psychological interventions.     

Habitual starvation and provocative behaviors: Two potential routes to extreme suicidal behavior in anorexia nervosa

Anorexia nervosa (AN) is perhaps the most lethal mental disorder, in part due to starvation-related health problems, but especially because of high suicide rates. One potential reason for high suicide rates in AN may be that those affected face pain and provocation on many fronts, which may in turn reduce their fear of pain and thereby increase risk for death by suicide. The purpose of the following studies was to explore whether repetitive exposure to painful and destructive behaviors such as vomiting, laxative use, and non-suicidal self-injury (NSSI) was a mechanism that linked AN-binge-purging (ANBP) subtype, as opposed to AN-restricting subtype (ANR), to extreme suicidal behavior. Study 1 utilized a sample of 787 individuals diagnosed with one or the other subtype of AN, and structural equation modeling results supported provocative behaviors as a mechanism linking ANBP to suicidal behavior. A second, unexpected mechanism emerged linking ANR to suicidal behavior via restricting. Study 2, which used a sample of 249 AN patients, replicated these findings, including the second mechanism linking ANR to suicide attempts. Two potential routes to suicidal behavior in AN appear to have been identified: one route through repetitive experience with provocative behaviors for ANBP, and a second for exposure to pain through the starvation of restricting in ANR.     

Individuation and Attachment in Israel and Thailand: Secular Versus Religious Jews and Buddhists

Two of the most important constructs in social, developmental, and clinical psychology are attachment and individuation. This study examined the impact of degree and type of religion on them by comparing the results of religious-national type (Israeli Jewish vs. Thai Buddhist) and degree of religiosity (religious vs. secular) on four subscales of the Individuation-Attachment Questionnaire: Need for Individuation, Fear of Individuation, Need for Attachment, and Fear of Attachment. Four groups of participants were compared: 61 religious Israeli Jews, 71 secular Israeli Jews, 17 religious Thai Buddhists, and 20 secular Thai Buddhists. Significant differences were found on all subscales, with religious Thai Buddhists lowest on all four of them. The secular Thais were highest in Fear of Individuation and Attachment and Need for Individuation. The religious Israeli Jews were highest in Need for Attachment. Because these concepts are sometimes difficult to distinguish, correlations were calculated to determine whether and which concepts were confabulated by each group, shedding further light on their views of interpersonal distance. These results were analyzed through examination of the differing worldviews and observances of Judaism and Buddhism with regard to individuation and attachment. Striking differences were found in the comparative narratives, leading to differential schemata for individuation and attachment, for both religious and secular subsamples within each religious-national community. These religious-national milieus were found to influence attitudes and behaviors toward one's ideal concept of interpersonal distance, specifically with regard to the constructs of individuation and attachment. Attachment is highly valued in Judaism, whereas detached compassion is the goal of Buddhistic teaching.