The adrenergic receptor α-2A gene (ADRA2A) and neuropsychological executive functions as putative endophenotypes for childhood ADHD

There is resurgent interest in the psychiatric literature in endophenotypes, variables thought to more strongly reflect the effects of candidate genes than do manifest disorders. In a sample of 176 children with attention deficit hyperactivity disorder (ADHD) and 52 of their siblings, we examined the validity of several putative endophenotypes for ADHD that represent commonly used clinical measures of multiple cognitive/neuropsychological domains of executive functions (EFs). We review their distributional normality, their relations to ADHD symptoms in probands and unaffected siblings relative to nonADHD controls, and their correlation in siblings. We also tested the EF measures’ associations with the ADRA2A gene and whether they mediated or moderated the associations between ADHD and ADRA2A. Several EF measures showed association with ADRA2A, as well as moderation, but not mediation, of its association with ADHD. Implications of the results for evaluating the validity and utility of putative endophenotype measures and for finding candidate gene effects on ADHD are discussed.     

The role of optimism in social network development, coping, and psychological adjustment during a life transition.

The authors investigated the extent to which social support and coping account for the association between greater optimism and better adjustment to stressful life events. College students of both genders completed measures of perceived stress, depression, friendship network size, and perceived social support at the beginning and end of their 1st semester of college. Coping was assessed at the end of the 1st semester. Greater optimism, assessed at the beginning of the 1st semester of college, was prospectively associated with smaller increases in stress and depression and greater increases in perceived social support (but not in friendship network size) over the course of the 1st semester of college. Mediational analyses were consistent with a model in which increases in social support and greater use of positive reinterpretation and growth contributed to the superior adjustment that optimists experienced.     

Crying threshold and intensity in major depressive disorder

Clinical lore suggests that depression is associated with frequent and intense crying. To test these postulations empirically, a standardized cry-evoking stimulus was presented to depressed and nondepressed participants, and their likelihood of crying and the magnitude of crying-related changes in their emotion experience, behavior, and autonomic physiology were compared. Unexpectedly, crying was no more likely in depressed than in nondepressed participants. Within the nondepressed group, participants who cried exhibited increases in the report and display of sadness and had greater cardiac and electrodermal activation than did participants who did not cry. There was less evidence of this crying-related emotional activation within the depressed group. The lack of emotional activation among clinically depressed participants who cried provides a tantalizing clue concerning how emotions are dysregulated in this disorder.     

It is written all over your face: Socially rejected people display microexpressions that are detectable after training in the Micro Expression Training Tool (METT)

Social rejection is a powerful negative emotional experience, yet rejected people often appear stoic and unmoved. That is, their macroexpressions of emotion are not accurate reflections of their emotional states. Yet, there is reason to believe that rejected people exhibit involuntary microexpressions of negative emotion. We contrasted people's macroexpressions of emotion with their microexpressions subsequent to an acceptance or rejection experience. Observers coded microexpressions after being trained with the Micro Expression Training Tool. Rejected participants expressed more sad and angry microexpressions than did accepted participants. This research demonstrates that socially rejected people display negative microexpressions that are detectable by observers trained in the Micro Expression Training Tool.     

Short‐term and working memory: Past,progress, and prospects

Abstract

The role of current personal experience in understanding of word meaning was investigated in a patient, WM, who suffers from semantic dementia. The study was prompted by the observation that WM, despite being severely impaired on formal tests of word comprehension and naming, retained a range of vocabulary pertaining to her daily life. If autobiographical experience has a general facilitatory effect, then this should affect which concepts are retained and which lost, but not influence the quality of that conceptual knowledge. Conversely, if personal autobiography has a direct role in investing concepts with meaning, then WM's understanding of nominal terms that she uses spontaneously in conversation ought not to be normal, but should be constrained by the autobiographical context in which she uses those terms. WM could define nouns and noun phrases drawn from her conversational vocabulary, but her definitions had a markedly autobiographical quality. Moreover, WM was extremely impaired in her ability to define new noun phrases, constructed by combining words from her conversational vocabulary (e.g. “dog licence”, constructed from “driving licence” and “dog” “oil field” constructed from “oil” and “field”). It was concluded that WM does not have normal conceptual understanding of nouns and noun phrases that she uses appropriately in conversation. Her understanding is narrow and autobiographically constrained. The findings, which suggest an interactive relationship between autobiographical and semantic memory, have implications for understanding of the progressive breakdown of semantic knowledge.     

Social status,cognitive ability,and educational attainment as predictors of liberal social attitudes and political trust

We examined the prospective associations between family socio-economic background, childhood intelligence (g) at age 11, educational and occupational attainment, and social attitudes at age 33 in a large (N = 8804), representative sample of the British population born in 1958. Structural equation Modeling identified a latent trait of ‘liberal social attitudes’ underlying attitude factors that are antiracist, socially liberal, and in support of gender equality. Another attitude factor—‘political trust’—was relatively independent from the latent attitude trait and has somewhat different pathways in relation to the other variables included in the analysis. There was a direct association between higher g at age 11 and more liberal social attitudes and political trust at age 33. For both men and women the association between g and liberal social attitudes was partly mediated via educational qualifications, and to a much lesser extent via adult occupational attainment. For women the association between g and political trust was partly mediated through both educational qualification and occupational attainment, and for men it was mediated mainly via occupational attainment. Men and women who had higher educational qualifications and higher occupational status tend to be more socially liberal and more trusting of the democratic political system. In terms of socio-economic background, people from less privileged families showed less political trust, but did not differ much in liberal social attitudes from those born into relatively more privileged circumstances. This study shows that social background, cognitive ability, education, and own social status influence perceptions of society.     

Recognition and recall of invisible objects

Three experiments examined recognition and recall of items that people imagined as being invisible. When one item hid another, the hidden item suffered in recognition, but so did the one that remained visible; the demand to imagine items invisibly made both items less recognizable than in control conditions. Cued recall did not depend on whether the visible item or the invisible item was the cue, but it did depend on whether the initial task required relational processing of the items. When both items were invisible in a dark imaginary scene, there was a general loss in all measures of memory, including memory for the scene. None of the results requires recourse to the “out of sight, out of mind” principle that memory depends on the visual characteristics of images. The results attest, instead, to the importance of the informational characteristics of memorial records.     

Neuroscience, Artificial Intelligence, and Human Nature: Theological and Philosophical Reflections

I develop a multilevel, holistic view of persons, emphasizing embodiment, emotions, consciousness, and the social self. In successive sections I draw from six sources: 1. Theology . The biblical understanding of the unitary, embodied, social self gave way in classical Christianity to a body-soul dualism, but it has been recovered by many recent theologians. 2. Neuroscience . Research has shown the localization of mental functions in regions of the brain, the interaction of cognition and emotion, and the importance of social interaction in evolutionary history and child development. 3. Artificial intelligence . Some forms of robotics use embodied systems that learn by interacting with their environment, but the possibilities for emotion, socialization, and consciousness in robots remain problematic. 4. Relations between levels . Concepts that can help us relate studies of neurons and persons include the hierarchy of levels, the communication of information, thebehavior of dynamic systems, and epistemological and ontological emergence. 5. Philosophy of mind . Two-aspect theories of the mind-brain relation offer an alternative between the extremes of eliminative materialism and the thesis that consciousness is irreducible. 6. Process philosophy . I suggest that process thought provides a coherent philosophical framework in which these themes can be brought together. It combines dipolar monism with organizational pluralism, and it emphasizes embodiment, emotions, a hierarchy oflevels, and the social character of selfhood.