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161.
Xenotransplantation, or the use of animal cells, tissues and organs for humans, has been promoted as an important solution
to the worldwide shortage of organs. While scientific studies continue to be done to address problems of rejection and the
possibility of animal-to-human virus transfer, socio-ethical and legal questions have also been raised around informed consent,
life-long monitoring, animal welfare and animal rights, and appropriate regulatory practices. Many calls have also been made
to consult publics before policy decisions are made. This paper describes the Canadian public consultation process on xenotransplantation
carried out by the Canadian Public Health Association in an arm’s length process from Health Canada, the ministry overseeing
government health policy and regulation. Focusing on six citizen fora conducted around the country patterned after the citizen
jury deliberative approach, the paper describes the citizen panelists’ recommendations to hold off on proceeding with clinical
trials and the rationales behind this recommendation. The consultation process is discussed in the context of constructive
technology assessment, a framework which argues for broader input into earlier stages of technology innovation, particularly
at the technology design stage.
This study was supported by a grant to the first author from the Social Sciences and Humanities Research Council in Canada. 相似文献
162.
163.
An adult California sea lion (Zalophus californianus) with extensive experience in performing discrimination learning tasks was tested to evaluate her long-term memory for two
previously learned concepts. An associative concept, that of equivalence classification, was retested after a retention interval
of approximately 1 year. The sea lion had originally shown emergent equivalence classification with nonsimilarity-based classes
of stimuli in a simple discrimination repeated-reversal procedure as well as in a matching-to-sample procedure. The 1-year
memory test revealed no decrement in classification performance in either procedure. A relational concept, that of generalized
identity matching, was retested after approximately 10 years. The sea lion had originally received trial-and-error exemplar
training with identity matching-to-sample problems prior to transferring the concept to novel stimulus configurations. In
the 10-year memory test, the sea lion immediately and reliably applied the previously established identity concept to familiar
and novel sets of matching problems. These are the first reports of long-term conceptual memory in a nonprimate species. The
experimental findings are consistent with a variety of observations of sea lions in natural settings, which indicate that
natal sites, feeding areas, and individuals may be remembered over long periods of time. Electronic Supplementary Material is available if you access this article at http://dx.doi.org/10.1007/s10071-002-0153-8. On that page (frame on the left side),
a link takes you directly to the supplementary material.
Electronic Publication 相似文献
164.
Nieuwenhuis S Ridderinkhof KR Talsma D Coles MG Holroyd CB Kok A van der Molen MW 《Cognitive, affective & behavioral neuroscience》2002,2(1):19-36
When participants commit errors or receive feedback signaling that they have made an error, a negative brain potential is elicited. According to Holroyd and Coles’s (in press) neurocomputational model of error processing, this error-related negativity (ERN) is elicited when the brain first detects that the consequences of an action are worse than expected. To study age-related changes in error processing, we obtained performance and ERN measures of younger and high-functioning older adults. Experiment 1 demonstrated reduced ERN amplitudes in older adults in the context of otherwise intact brain potentials. This result could not be attributed to uncertainty about the required response in older adults. Experiment 2 revealed impaired performance and reduced response- and feedback-related ERNs of older adults in a probabilistic learning task. These age changes could be simulated by manipulation of a single parameter of the neurocomputational model, this manipulation corresponding to weakened phasic activity of the mesencephalic dopamine system. 相似文献
165.
Manbir?SodhiEmail author Bryan?Reimer Ignacio?Llamazares 《Behavior research methods》2002,34(4):529-538
With the increasing use of in-vehicle devices in cars, an understanding of the safety implications of secondary tasks has become crucial. It is now possible to study the effects of many in-vehicle devices and tasks on driving by using head-mounted eye-tracking devices (HEDs) to collect eye positions and pupil diameters, which have been considered indicators of attentional focus. The collection of eye-position and pupil-diameter data of automobile drivers under on-road conditions and while completing various secondary tasks is described in this paper. Drivers were asked to drive on a preselected two-lane road for a total distance of 22 miles while gaze data were recorded using a HED. Longer off-road fixation durations were observed in radio-tuning and rearview mirror checking tasks, but not in the odometer checking task. In addition, the standard deviations of fixation displacements during a cognitive task involving the computation of a date for a meeting were shorter than those observed during normal driving. 相似文献
166.
Laura?Barca Cristina?BuraniEmail author Lisa?S.?Arduino 《Behavior research methods》2002,34(3):424-434
The present study describes normative measures for 626 Italian simple nouns. The database (LEXVAR. XLS) is freely available for down-loading on the Web site http://wwwistc.ip.rm.cnr.it/material/ database/. For each of the 626 nouns, values for the following variables are reported: age of acquisition, familiarity, imageability, concreteness, adult written frequency, child written frequency, adult spoken frequency, number of orthographic neighbors, mean bigram frequency, length in syllables, and length in letters. A classification of lexical stress and of the type of word-initial phoneme is also provided. The intercorrelations among the variables, a factor analysis, and the effects of variables and of the extracted factors on word naming are reported. Naming latencies were affected primarily by a factor including word length and neighborhood size and by a word frequency factor. Neither a semantic factor including imageability, concreteness, and age of acquisition nor a factor defined by mean bigram frequency had significant effects on pronunciation times. These results hold for a language with shallow orthography, like Italian, for which lexical nonsemantic properties have been shown to affect reading aloud. These norms are useful in a variety of research areas involving the manipulation and control of stimulus attributes. 相似文献
167.
Shepherd I. Franz was an important figure in psychology of the last century, and historians of psychology have given recognition
to much of his work. However, his experimental work with animals and his pioneer investigations in experimental and clinical
neuropsychology have been largely ignored. This article reviews his conceptual, assessment, and treatment contributions, including
(1) his pioneering work on the use of learned behavior as a baseline for the study of cerebral ablations, (2) his interest
in brain plasticity, (3) his development of comprehensive psychological assessment methods, and (4) his work on the rehabilitation
of neurological patients with techniques derived from his animal experiments. His work predated much of what is now part of
the conceptual substance of the experimental and clinical neurosciences. 相似文献
168.
The frequency of theta activity may be important for hippocampal function. Anxiolytic drugs reduce theta frequency and have behavioral effects that are similar to those of hippocampal lesions. The effect of the anxiolytic benzodiazepine chlordiazepoxide (CDP) on theta frequency is partially mediated by the medial supramammillary nucleus (mSuM), part of an ascending theta-activating system. Rats were trained on the hippocampal-sensitive fixed-interval 60-sec schedule (FI60). CDP (5 mg/kg i.p.) released responding suppressed by nonreward, seen as increased leverpressing, and reduced theta frequency concurrently. Microinfusion of CDP (20 μg in 0.5 μl saline) into mSuM had as large effects on both frequency and behavior. Other nuclei mediate the benzodiazepine reduction of theta frequency in the open field and the water maze. But the mSuM appears to be the major, if not sole, nucleus controlling theta frequency and, so, hippocampal-mediated behavioral inhibition in the FI60 lever task. 相似文献
169.
170.
Kevin?D.?BeckEmail author Francis?X.?Brennan Richard?J.?Servatius 《Integrative psychological & behavioral science》2002,37(2):128-139
In this study we assessed habituation and sensitization of the acoustic startle response (ASR) to discern whether intense,
inescapable stress affects nonassociative learning differently in male and female rats. Rats were inescapably stressed 2 hours
per day over 3 consecutive days. ASR magnitudes were measured at several times post-stress (1, 4, 8, and 15 days after cessation).
Females generally showed greater ASR magnitudes (compared to males), but both sexes exhibited short and long-term habituation
across the testing days. ASR magnitudes were only affected by stress in male subjects. The effect in males was an increase
in short-term sensitization of the ASR on post-stress day-4. The results suggest that stressed males and females react differently
to ASR testing, in that stress males appear to develop an exaggerated ASR response over repeated test sessions due to short-term
sensitization. The source of the short-term sensitization is discussed with regards to possible stress-induced enhanced contextual
learning during ASR testing on post-stress day-1. 相似文献