FDA儿童药物临床试验规范化对我国的启示

对美国食品药品监督管理局（Food and Drug Administration,FDA）儿童药物临床试验的规范化进行界定,发现我国面临儿童用药方面存在安全隐患、儿童药物临床试验存在需求缺口、儿童药物临床试验审查不够规范等现实困境,引发规范儿童药物临床试验的关键性思考。借鉴FDA对儿童药物临床试验的规范化实践,总结FDA儿童药物临床试验相关法案、临床试验指南文件以及对伦理审查委员会的监管措施,得出完善儿童药物临床试验专门法规和指南、加强相关伦理委员会监管和指导、规范儿童药物临床试验伦理审查、加大儿童受试者保护力度等对我国的启示。

     

Selfish power and unselfish status in Chinese work situations

The present research explored the selfishness of power and status as well as the mechanism in Chinese work situations. By using experimental and survey methods, two studies were designed to investigate the relationships among power, status, and self‐interested behaviour (SIB) as well as the mediating effect of perspective‐taking (PT). Results of the two studies consistently indicated that power increases whereas status reduces SIB. These opposing behavioural effects are partially attributed to the fact that power reduces whereas status increases PT. In addition, our results showed an interaction between power and status on SIB in Study 1 (interaction as a mental function), and a positive correlation between perceived power and status in Study 2 (correlation as a mental perception). Through the discussion from the perspective of the self/other‐orientation trait, as well as the stable effects of power and status on SIB in the two studies, we conclude that power is selfish and status is unselfish in Chinese work situations.     

Belief in Hell and Parenting Priorities Concerning Child Independence and Obedience: Does Economic Context Matter?

This study examines the ways that belief in hell is associated with parental goals concerning child independence and obedience. Further, it assesses how this association is contingent upon economic circumstances of a nation, reflected by a country's Gross Domestic Product (GDP) per capita. Multilevel analyses with data from the sixth wave of the World Values Survey (2010-2014) show that belief in hell is associated with a greater likelihood of opposing independence and endorsing obedience. Yet, these observed associations differ across national economic context. Specifically, the negative association between belief in hell and parental endorsement of independence is greater in countries that are more economically developed. Similarly, the positive association between belief in hell and parental endorsement of obedience is greater in countries that are more economically developed. The theoretical implications of these findings are discussed regarding the interplay of religion, parental values about child socialization, and social context.     

Bilateral Transcranial Direct Stimulation Over the Primary Motor Cortex Alters Motor Modularity of Multiple Muscles

Abstract

Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) has been demonstrated to modulate the motor performance of both healthy individuals and patients with neuromuscular disorders. However, the effect of tDCS on motor control of multiple muscles, which is a prerequisite to change in motor performance, is currently unknown. Using dimensionality reduction analysis, we investigated whether bilateral tDCS over M1 modulates the coordinated activity of 12 muscles. Fifteen healthy men participated in this randomized, double-blind crossover study. Each participant received a 20-min sham and 2-mA stimulation bilaterally over M1 (anode on the right M1 and cathode on the left M1), with a minimum washout period of 4?days. Muscle activation and end-point kinematics were evaluated during a task where participants reached out to a marked target with non-dominant hand as fast as possible, before and immediately after tDCS application. We found decreased similarity in motor modularity and significant changes in muscle activation in a specific motor module, particularly when reaching out to a target placed within arm’s length and improved smoothness index of movement only following 2-mA stimulation. These findings indicate that clinicians and researchers need to consider the simultaneous effect of bilateral tDCS over M1 on multiple muscles when they establish tDCS protocol to change in motor performance of patients with neuromuscular deficits.     

句子加工的脑成像研究

近年来句子加工的脑成像研究大量涌现,并集中于揭示句子语义与语法加工的神经机制以及之间的联系。文章首先对这些研究所采用的范式加以分析与比较,从而将句子加工脑成像研究的研究思路与常用范式进行了归纳与总结。其次,讨论了语义加工与语法加工的神经机制,并根据现有的研究结果,对句子语义与语法两个成分在认知加工与神经机制上的共性与特性做出推论。最后,从语言的多样性以及影响句子加工的因素两个角度,对以后的句子加工脑成像研究做了展望。     

论网络文化条件下大学生道德人格的培育

网络技术的普及和运用对大学生道德人格的培育产生了深远的影响.大学生道德人格培育的关键是培育大学生的网络道德人格.通过把握虚拟性与真实性、多元性与普适性、共性与个性的统一,认清网络道德人格的实质.大学生网络道德人格的外部型塑不仅需要大学生在自我塑造上积极地正身、修己、明志,同时需要作为外因的高校道德教育树立大德育观念,提高教育者自身的素质,注重网络文化环境建设,以此调动学生自我探求、自我创造、自我约束、自我修养的积极意识.     

气质和儿童同伴交往类型关系的研究

该文采用问卷法和社会测量法相结合的方法,以班级为单位对484名3~9岁儿童的气质和同伴关系类型的关系进行研究。结果表明:3~9岁儿童同伴关系类型已形成分化,其中被忽视儿童和被拒绝儿童所占总体样本的比例分别为16.9%和9.6%,比例较高值得重视。儿童气质对同伴交往类型的形成影响很大,四种同伴关系交往类型在气质各维度上方差检验都达到了差异显著,有着明显不同的气质特点。     

Sense of Divine Involvement and Sense of Meaning in Life: Religious Tradition as a Contingency

This study examines the association between sense of divine involvement and sense of meaning in life. Then it proceeds to assess how this association varies by religious tradition. Using a random and national sample from the 2007 Baylor Religion Survey, this study finds that sense of divine involvement is associated with greater odds of having a sense of meaning in life. In addition, religious affiliation modifies this association. Specifically, the positive association between sense of divine involvement and the odds of having a sense of meaning in life is observed only among evangelical Protestants, mainline Protestants, and Catholics, but not among other religionists and religious nones. I discuss how the results make contributions to knowledge about the link between religious beliefs, religious tradition, and mental health.     

ŚŪNYATĀ AND KOKORO: SCIENCE–RELIGION DIALOGUE IN THE JAPANESE CONTEXT

When we read books or essays about the dialogue between “religion and science,” or when we attend conferences on the theme of “religion and science,” we cannot avoid the impression that they actually are dealing, almost without exception, not with a dialogue between “religion and science,” but with a dialogue between “Christianity and science.” This could easily be affirmed by looking at the major publications in this field. But how can the science–religion dialogue take place in a world where conventional Christian concepts of God, religion, and science are foreign and unfamiliar? Is the critique that the scientist plays God still valid when there is no “God” at all? This article tries to answer the questions mentioned above, and seeks to sketch out some aspects of the science–religion dialogue in Japan which I believe could contribute a new paradigm for understanding and describing ultimate reality.     

罗夏综合系统的元分析*

为考察罗夏墨迹测验Exner综合系统常模的客观性和准确性,运用元分析的方法,将来自16个国家的18篇罗夏综合系统正常成人的研究结果,与Exner新版常模进行比较。结果显示,在综合系统的全部113个变量中,有23个变量在联合样本与Exner常模间存在显著差异,包括被试的资源、能力、认知水平和人际关系等方面,且均为Exner常模样本结果更加优秀。结论:新版罗夏综合系统常模具有一定的偏差,存在偏好倾向,使用时应注意避免对被试的低估甚至做出假阳性的诊断。