早期剥夺所致大鼠抑郁样行为与海马BDNF mRNA表达变化

为探讨早期剥夺对大鼠行为与海马脑源性神经营养因子(BDNF)mRNA表达的影响,将新生的SD大鼠随机分为正常对照组与早期剥夺组,早期剥夺组在出生后1～14d每天孤养4h。监测体重,在出生后36?64天进行液体消耗试验,每周一次。12w龄时,进行穿梭箱试验,酶联免疫法检测海马BDNF含量,原位杂交法观察海马BDNF mRNA的表达。早期剥夺组大鼠体重显著低于正常对照组(p0.01),糖水摄入量与糖水偏爱显著低于正常对照组(p0.05或p0.01)。穿梭箱试验中,早期剥夺组大鼠在训练时的穿梭反应次数显著少于正常对照组(p0.05),在测试时,两组大鼠的被动逃避行为、主动逃避行为与逃避错误次数无显著差异。早期剥夺组大鼠海马BDNF含量、CA1区和CA3区BDNF mRNA表达显著低于正常对照组(p=0.05或p0.05)。提示早期剥夺可导致大鼠生长减慢,表现出快感缺失的抑郁样行为,但未诱导成年大鼠表现出明显的习得性无助倾向,早期剥夺能下调成年大鼠海马BDNFmRNA的表达。     

群体水平领域分数及其估计方法

对人才的需求已经引起各国政府和国际组织对教育的高度重视,纷纷在国家和地区层面进行大规模的教育评估。在大尺度教育评估中,如何向政府、管理者和公众报告学生表现是不可避免的重要问题。报告学生表现有多种方式,领域分数作为管理者和公众最容易理解和接受的分数报告工具之一,在近些年受到研究者和实践者的关注,因此也成为了大型教育评价项目的必然选择。文中将介绍群体领域分数的起源和定义,并重点介绍群体领域分数的估计方法和相关研究,最后对未来开展进一步研究进行展望。     

Theological foundations for spiritual care

Five theological tenets are described which may undergird the integration of religious awareness and spiritual care into nursing curricula. The five all emphasize addressing the articulated needs of the patient within the context of the nursing process. These tenets, while Wesleyan in emphasis, suggest ways in which any nurse may engage in the common ministry of all Christians without usurping the role of clergy or chaplains.This article is a revision of a chapter of Dr. Brittain's doctoral dissertation from St. Mary's Seminary and University.     

The unconscious in pastoral psychology: a rabbinic perspective

The present essay reviews the rabbinic theology of person as it has been outlined within the corpus of talmudic and rabbinic literature. Concepts such as libido, id, and superego are located in the rabbinic notions ofyezer harah andyezer tov (evil impulse and good impulse). Sexuality, as a paradigm of the Divine-human encounter, is explored in rabbinic and kabbalistic literature, and a model of transference is analyzed. Furthermore, a comparison is examined between rabbinic exegesis and psychoanalytic interpretation. It is suggested that the pastoral counselor may develop a theologically more authentic orientation to pastoral therapy by reflecting upon its origins in rabbinic thought.     

知识向技能转化的影响因素

将知识向技能的转化过程分为 :陈述性编码阶段、程序性编码阶段 ,并假设存在一些因素影响陈述性编码向程序性编码的转化过程 ,控制好这些关键因素将有利于提高教学质量。为证明此假设 ,设计了四个实验。实验一、二结果表明 ,发现学习和接受学习中原有知识水平、概念地图策略等因素显著影响陈述性编码阶段 ;实验三、四结果表明 ,发现学习和接受学习中变式练习、解题策略指导等因素显著影响程序性编码阶段 ,对以上实验数据的再分析得出这两阶段存在明显的相互制约关系 ,根据以上结论和 E.D.Gagne的信息加工模型 ,构建了一个智慧技能获得的信息加工模型。     

智慧技能的一般教学模型与实验验证

该文给出了智慧技能的一般教学模型 ,将智慧技能的教学分为两个主要阶段 :陈述性编码阶段、程序性编码阶段。为验证此模型在教学实践中的可行性 ,在课堂教学情境中进行了模拟实验。选取同一所学校初二年级的四个班学生共 2 2 2人 ,随机安排四个班分别接受“欧姆定律”四种教案的教学 :发现式新教案、发现式旧教案、接受式新教案、接受式旧教案 ,随后进行迁移能力测验 ,结果表明采用新教案组织教学 ,即按上述模型控制好影响智慧技能的一些关键因素 ,将更利于学生获取智慧技能。     

CT scan and neuropsychological correlates of Alzheimer's disease and Huntington's disease

"Cortical" and "subcortical" dementia syndromes differ in areas of primary neuropathology and clinical characteristics. Conventional CT scan interpretation, visual inspection of pictures, has not been useful in studying dementia. Recent studies of the digitally stored CT attenuation values have found systematic variations with normal aging and aphasia subtypes. In this study of numerical CT scan information in four Alzheimer's Disease and two Huntington's Disease patients, a double dissociation of frontal and temporal lobe density values was found, and a significant correlation was found between left temporal lobe density and verbal ability measures in the Alzheimer's Disease patients.     

Dysfunctional Behavior among Sales Representatives: The Effect of Supervisory Trust,Participation, and Information Controls

This study investigates the efficacy of supervisory trust, participation, and information controls in curbing dysfunctional salesperson behavior so that salesperson actions are in line with organizational goals. Using a sample of 210 salespeople, we develop and test a model incorporating supervisory trust, participation, information controls (output information, activity information, and capability information), and dysfunctional behavior. Output and activity information controls directly affect dysfunctional behavior, whereas capability information controls work positively through trust in the supervisor to reduce dysfunctional behavior. Providing sales representatives with information about their capabilities appears to enhance the supervisor–salesperson trust relationship. Results also indicate that salespeople’s supervisory participation is an effective lever for reducing dysfunctional salesperson behavior through the intervening role of trust in the supervisor.