Is Speech Arrest during Wada Testing a Valid Method for Determining Hemispheric Representation of Language?

Background and objective: The intracarotid amobarbital procedure, or Wada test, is the method of choice to determine hemispheric representation of language, and is routinely used in the presurgical evaluation for intractable epilepsy. Some investigators perform comprehensive language assessments, but others base language lateralization solely on speech arrest. This study sought to determine whether speech arrest alone during Wada testing provides valid data regarding language lateralization. Methods: The subjects (previously reported) were 21 patients evaluated for intractable epilepsy, who underwent language lateralization by Wada testing and functional MRI (FMRI). For each patient, language representation was determined by calculating: (1) a Wada laterality index based exclusively on speech arrest; (2) a Wada laterality index based on comprehensive language assessment; and (3) an FMRI laterality quotient. Correlation coefficients and categorical classifications were analyzed. Results: There was no significant correlation between the Wada laterality quotient derived from duration of speech arrest and either the comprehensive Wada language laterality score (r= .35,p= .12) or FMRI language laterality score (r= .32,p= .16). Categorical classification as left, right or bilateral language also showed marked discordance between speech arrest and the other two methods. Conclusion: Duration of speech arrest during Wada testing is not a valid measure of language dominance.     

语义联系类型和强度对预期推理生成的制约作用

首先采用开放式问卷实验方法,由被试生成日常生活中的事件以及组成这些事件的各种活动和活动的参加者。然后,对这些事件熟悉性、对活动的典型性和可区分性三个维度进行主观评价,形成事件以及每个事件活动序列,并据此编制实验材料。实验主要考察活动的典型性和可区分性对于熟悉性高的事件的预期推理的影响,以及不同工作记忆能力的被试进行事件预期推理时的加工模式。实验结果表明：（１）高工艺记忆能力的被试对事件的预期量小于     

LTP诱导期向维持或转化过程中的突触形态学特征

该研究探讨了视皮层ＬＴＰ由诱导期向维持期转化过程的突触形态学特征。实验选用１８－３０天龄的健康ＳＤ大鼠,分实验组、空白对照组及实验对照组进行电镜观测和图象分析。结果发现,在常规ＬＴＰ实验程序中强直刺激后有ＬＴＰ产生并记录８０分钟的实验组脑片标片,局部有界面曲率大于２的较大Ｕ型突触形成,这种突触多有两个以上活性区。图象分析结果显示,实验组与对照组相比较,突触的界面曲率明显增大（Ｐ〈０．０５）,活性区     

阅读理解中的预期推理

从工作记忆能力的个体差异的角度,探讨阅读描述日常生活事件的段落时预期推理过程的资源分配特点,及其与阅读焦点转移的关系。结果表明,（１）预期推理可以维持较长时间。（２）工作记忆能力强的被试进行预期推理的范围较广;而工作记忆能力较弱的被试推理范围较小。（３）工作记忆能力较弱者对每一个项目的激活量较大。（４）对于非常熟悉的事件,预期推理不受焦点转移的影响。     

韦伯比的拟合公式

本文以神经生理学为基础,结合感官具有调节和比较两功能的实用性,建立起刺激在大脑皮层上引起感知效应Ｅ的数学模型：Ｅ＝Ｂｌｏｇ（１＋ｋＩ）,其中ｋ＝Ｉ￣（－ｂ）／ａ。从此出发,可推出中等以上刺激的差别阈判据：△ＥＭ＝恒量。将此判据推广到弱刺激,即得到差别阈的普适规律：△Ｉ／（Ｉ＋ａＩ￣ｂ）＝Ｎ,亦即韦伯定律的修订公式。从弱到强的广大刺激范围内,它都能与实验数据拟合良好。     

Retest stability of DSM-III-R diagnoses among adolescents using the diagnostic interview schedule for children (DISC-2.1C)

Retest stability of DSM-III-R diagnoses was assessed using the DISC-2.1C with a sample of Anglo, African, and Hispanic American adolescent patients 12 to 17 years of age. Based on the kappa statistic, retest stability was fair for any disorder ( =.50), for any anxiety disorder ( =.44), for any affective disorder ( =.53), for any disruptive behavior disorder ( =.58), and for substance use disorders ( =.46). Although there was a trend for reliability to be somewhat higher for African Americans ( =.58) than for Anglos ( =.42) or Hispanics ( =.49), these differences were not statistically significant. In general, 15- to 17-year-olds had somewhat better reliability ( =.58) than did 12- to 14-year-olds ( =.44). Males had somewhat higher reliability ( =.63) than females ( =.43). These findings are congruent with those reported recently using the DISC-R (Schwab-Stone et al., 1993) and suggest that the DISC appears to be at least as reliable as other available child diagnostic instruments. In view of the fair-to-moderate levels of reliability of these instruments in general, future research should focus on the joint effects of instrument, subject, interviewer, and nomenclature on operating characteristics of diagnostic interview schedules, focusing in particular on factors affecting accurate recall and reporting of symptoms and episodes. This research was supported in part by grants MH44214 and MH44773 from the National Institute of Mental Health, and by the Hogg Foundation for Mental Health. The authors wish to acknowledge the participation and collaboration of A. J. Pumariega, J. W. Swanson, and C. E. Holzer III and staff of the Center for Cross-Cultural Research, directed by F. M. Treviño.     

Compassion: An east‐west comparison

Compassion is an emotion that occupies a central position in Mahāyāna Buddhist philosophy while it is often a neglected subject in contemporary western philosophy. This essay is a comparison between an Eastern view of compassion based upon Mahāyāna Buddhist perspectives and a western view of the same emotion. Certain principles found in Mahāyāna Buddhist philosophy such as the Bodhisattva Ideal, and suffering (dukkha) to name two, are explored for the information they contain about compassion. An essay by Lawrence Blum is taken as representative of a Western view (but not exclusively) and it is analyzed for its shortcomings in light of the Buddhist view. The conclusion briefly describes the value of understanding an eastern view on compassion as a means of filling the void one finds in western medical ethics discourse which focuses so heavily, and redundantly, upon issues such as patient autonomy and paternalism.     

汉语语义记忆提取的初步研究

对汉语语义记忆的提取进行了两个实验。实验1是自由联想实验,从十三个句子中选出二十三个词作为刺激词。结果表明,以两词间所保持的常识关系来定义的语义距离,对预测自由联想的作业是有效的。实验2采用反应时技术,对真假命题判断及信息提取的时间进行了考查。实验结果与A.M.Collins等人的结果一致,说明了存储于网络不同水平上的句子其提取时间不同这一事实。结果还表明,在信息提取阶段上,汉字字形的作用不是一个重要的因素。     

A critical review of theS/L reliability index

The meaning and properties of a commonly used index of reliability, S/L,were examined critically. It was found that the index does not reflect any conventional concept of reliability. When used for an identical behavioral observation session, it is not statistically correlated with other reliability indices. Within an observation session, the standardizing measure of Lis beyond the control of the investigator. Furthermore, the reason for the choice of Las the standard is unclear. The role of chance agreement in S/Lis not known. The exact interpretation of the index depends on which observer reports L.Overall the conceptual and mathematical meaning of S/Lis dubious. It is suggested that the S/Lindex should not be used until its nature is shown to be a measure of reliability. Other approaches such as the intraclass correlations and generalizability coefficients should be used instead.The authors are indebted to Johnny Matson for his critique of an earlier version of this paper.     

Children's responses to stories with male and female characters

The sex of the main character was varied in six children's stories which were then read by fourth, sixth and eighth graders. The children answered four questions about the stories. Both boys and girls responded more positively to the questions “Would you like to be (character's name?)” and “Would you like to do the things (character's name) did?” when the main character was a male. Boys preferred stories about males, and this preference increased with grade level. A preference for stories about females was marginally significant only for the older girls. Theoretical and practical implications are discussed.