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971.
O'Shea R Murphy AM Treacy E Lynch SA Thirlaway K Lambert D 《Journal of genetic counseling》2011,20(2):192-203
Many children with chronic genetic diseases are followed by specialty clinics that provide genetic information as part of
the care. Health services restrictions in the Republic of Ireland (ROI) can make the wait for an appointment with a genetic
counsellor long. We examined whether genetic information was being adequately understood when presented by medical, but non-genetics
staff to long term patients, using our national metabolic service as an example. The aim was to inform health professionals
about the need or role of a genetic counsellor in a specialist setting. A questionnaire was used to assess knowledge among
parents and patients affected by galactosaemia and Maple Syrup Urine Disease (MSUD). Twenty seven families with galactosemia
and 10 with MSUD were interviewed in clinic. Comparative analysis showed significant differences in knowledge between parents
of children with galactosemia and adult patients (p = 0.001) and between ethnicities (p > 0.05). While parents are well informed, the majority expressed a wish for more information about the condition and its
transmission. Adult patients with galactosemia and parents from certain ethnic backgrounds could especially benefit from genetic
counselling. This study highlights the need for a genetic counsellor in specialist clinics. 相似文献
972.
McCuaig JM Greenwood CM Shuman C Chitayat D Murphy KJ Rosen B Armel SR 《Journal of genetic counseling》2011,20(5):442-449
Five to 10% of all cases of breast and ovarian cancer are attributed to a heritable genetic predisposition. Transmission of
BRCA1 and BRCA2 mutations is equally likely through maternal or paternal lineage; however, fewer referrals to cancer genetics clinics appear
to be made for a paternal, than maternal, family history of breast and/or ovarian cancer. To examine this potential bias,
a retrospective review of 315 patient and family charts was conducted by one familial cancer clinic in Toronto, Canada. Referral
letters, risk estimates, and family histories were analyzed to identify significant differences between patients referred
with maternal and paternal family histories. It was determined that patients are approximately five times more likely to be
referred with a maternal family history of breast and/or ovarian cancer as compared to those with a paternal family history
(p = <.0001). Individuals with a paternal family history were found to have a different, and higher, pattern of risk estimates
(p = .00064). No significant difference was seen between the type of referrals sent by general practitioners, oncologists, and
gynecologists. Recommendations to increase the awareness of paternal family history in assessing cancer risk are provided. 相似文献
973.
Within philosophy there has been little discussion of the risks associated with natural events such as earthquakes. The first
objective of this paper is to demonstrate why such risks should be the subject of more sustained philosophical interest. We
argue that we cannot simply apply to risks associated with natural events those insights and frameworks for moral evaluation
developed in the literature considering ordinary risks, technological risks and the risks posed by anthropogenic climate change.
The second objective of this paper is to identify and develop a framework for the moral evaluation of the source of the risks
associated with natural events, or the actions which sustain and impact such risks. Our discussion concentrates on the ways
the construction and modification of built and natural environments can alter the probability of occurrence of natural events
and the character and magnitude of the impact that such events have. We then argue for the need to develop a standard of reasonable
care for decisions about the built and modified natural environment, which accounts for technical and resource constraints,
as well as the place of natural hazard mitigation in public policy. 相似文献
974.
We examined emotional responding to music after mood induction. On each trial, listeners heard a 30-s music excerpt and rated how much they liked it, whether it sounded happy or sad, and how familiar it was. When the excerpts sounded unambiguously happy or sad (Experiment 1), the typical preference for happy-sounding music was eliminated after inducing a sad mood. When the excerpts sounded ambiguous with respect to happiness and sadness (Experiment 2), listeners perceived more sadness after inducing a sad mood. Sad moods had no influence on familiarity ratings (Experiments 1 and 2). These findings imply that "misery loves company." Listeners in a sad mood fail to show the typical preference for happy-sounding music, and they perceive more sadness in music that is ambiguous with respect to mood. 相似文献
975.
The current study investigated the role of relational challenges as reported by 309 protégés in various stages and types of mentoring relationships. The Mentoring Relationship Challenges Scale (MRCS) was newly constructed using the results of an earlier qualitative study (Ensher & Murphy, 2005). The scale measured three factors of relational challenges which were: Demonstrating Commitment and Resilience, Measuring Up to a Mentor's Standards, and Career Goal and Risk Orientation. The results demonstrated that with respect to mentoring stages, those protégés in the beginning stages of their relationships reported experiencing significantly fewer challenges related to Demonstrating Commitment and Resilience than those in the mature or ending stages of the relationship. Also, it was found that the type of mentoring relationship (traditional, step-ahead, or peer) affected the prevalence of the three types of challenges. Protégés in peer relationships reported significantly fewer of all three types of challenges than those in step-ahead or traditional relationships. However, contrary to predictions, there were no significant differences found between those in informal versus those in formal mentoring relationships. As expected, protégé and mentor gender interacted significantly. Female protégés reported experiencing significantly fewer challenges related to the factor of Measuring Up to a Mentor's Standards, than did male protégés. Also, female protégés reported experiencing a significantly higher degree of relational challenges related to Career Goal and Risk Orientation from their male mentors than from their female mentors. Finally, after controlling for perceptions of career and psychosocial support for protégés in traditional mentoring relationships, two of the three relational challenges factors remained significant and explained a significant amount of variance in overall satisfaction with the mentoring relationship. This suggests that relational challenges, at least for traditional mentoring relationships, serve as an important mechanism to impact overall relationship satisfaction. 相似文献
976.
Richard A. Bernardi Caryn L. Lecca Jennifer C. Murphy Elizabeth M. Sturgis 《Journal of Academic Ethics》2011,9(3):235-256
This study examined whether having attended a public, private or religious affiliated grade and/or high school influenced
a college student’s ethical decision making process. We also examined whether having taken an ethics course in college influences
a student’s ethical decision making process. Our sample included 508 accounting students (237 men and 271 women) from Albania,
Ecuador, Ireland and the United States. Our analyses indicated no differences in ethical decision making that associated with
either grade-or-high-school education. While our data showed no difference in the reported attitudes between students from
Ecuador and the United States after controlling for social desirability response bias, we found significant differences between
the attitudes students from the United States and students from both Albania and Ireland. While gender was also significant
for six of our seven scenarios, social desirability response bias was significant in all of our scenarios. 相似文献
977.
In this study, we examined a source-monitoring phenomenon that arises from reactivated related information from the study
phase. Three experiments showed that source attributions for target events were influenced not only by the target item itself,
but also by studied information about related items. In Experiment 1, source memory for target items that have a high forward association value to a single related study item (e.g., credit) were affected by the source of the associated information (e.g., card), so that memory performance was better when associated items were presented in the same source rather than a different source.
A similar effect occurred with bidirectional associates (Exp. 2), as well as with synonymous pairs of words (Exp. 3). We argue that the source information of the reactivated material can be commingled with information about a candidate during
a source judgment at retrieval and thereby can affect performance. 相似文献
978.
979.
Diane L. Gill Yu-Kai Chang Karen M. Murphy Kathryn M. Speed Cara C. Hammond Enid A. Rodriguez MinJeong Lyu Ya-Ting Shang 《Applied research in quality of life》2011,6(2):181-200
Despite the clear relationship of physical activity and quality of life (QoL), QoL measures are seldom targeted for physical
activity and health promotion. The current research attempted to address that gap by developing a QoL measure based on a conceptual
model that reflects positive health and is relevant for physical activity and health promotion programs. In the project, which
extended over three phases, an initial 70-item QoL survey was administered to university students and community program participants
(total n = 512) along with measures of satisfaction with life and physical activity. Exploratory and confirmatory factor analyses
revealed clear social, emotional, cognitive, physical, spiritual and functional (ADL) QoL factors as well as integrated QoL.
The resulting 32-item QoL Survey fits the conceptual model, demonstrates logical relationships with physical activity and
has sufficient psychometric properties for use in related research and health promotion programs. 相似文献
980.
Merideth Ferguson Dawn Carlson Emily M. Hunter Dwayne Whitten 《Journal of Vocational Behavior》2012,81(2):245-258
Building on the spillover and crossover literatures of work–family conflict and the theoretical framework of Conservation of Resources Theory (Hobfoll, 1989) we examine the effects of conflict on production deviance. Using a two-study constructive replication and extension design, we examine how partner work-to-family conflict contributes to job incumbent family-to-work conflict and subsequent engagement in production deviance. In addition, we examine the moderating role of gender on the incumbent family-to-work conflict to production deviance relationship. Study 1 of 344 job incumbents supported the positive relationship between incumbent family-to-work conflict and deviance. In addition, this was moderated by gender such that men engaged in more deviant behaviors in response to family-to-work conflict. Study 2 consisted of 190 matched job incumbents and their partners. These findings supported the mediation of partner work-to-family conflict to production deviance through incumbent family-to-work conflict. Again gender was supported using moderated mediation analysis such that men engaged in more deviant behaviors in response to family-to-work conflict. Implications for practice and future research are discussed. 相似文献