The effects of binge MDMA on acquisition and reversal learning in a radial-arm maze task

The current study used the partially-baited radial-arm maze paradigm to study the effects of a single-treatment high-dose exposure ('binge') to MDMA (± 3,4-methylenedioxymethaphemtamine or 'Ecstasy') on memory task acquisition. Sprague-Dawley rats were administered a binge dose (4 × 10 mg/kg) of MDMA and their ability to subsequently acquire the radial-arm maze task was compared against saline controls. The MDMA-treated rats were significantly slower to learn the task and made more reference memory errors than the controls. Working memory function was found to be relatively unimpaired. Following a reversal of task rules the MDMA-treated rats were again significantly slower to acquire the appropriate rule despite having eventually achieved a similar level of overall performance as control rats. However evidence of drug tolerance was found when all rats were challenged with an acute low dose of MDMA (1 × 4.0 mg/kg) because the binge MDMA rats were relatively less impaired. Therefore, although binge treated MDMA rats were able to achieve very accurate performance equivalent to the controls they took significantly longer to do this and were less able to adapt their behavior to a change in task rules. In addition the binge treated MDMA rats displayed tolerance to acute MDMA exposure. These findings are consistent with the possibility that human Ecstasy users may show deficits in acquiring information and may experience deficits in cognitive flexibility as well as developing tolerance to the drug with repeated exposure.     

The empirical case for role-governed categories

Most theories of categorization posit feature-based representations. Markman and Stilwell (2001) argued that many natural categories name roles in relational systems and therefore they are role-governed categories. There is little extant empirical evidence to support the existence of role-governed categories. Three experiments examine predictions for ways that role-governed categories should differ from feature-based categories. Experiment 1 shows that our knowledge of role-governed categories, in contrast to feature-based categories, is largely about properties extrinsic to category members. Experiment 2 shows that role-governed categories have more prominent ideals than feature-based categories. Experiment 3 demonstrates that novel role-governed categories are licensed by the instantiation of novel relational structures. We then discuss broader implications for the study of categories and concepts.     

CHANCE AND NECESSITY IN ARTHUR PEACOCKE'S SCIENTIFIC WORK

Arthur Peacocke was one of the most important scholars to contribute to the modern dialogue on science and religion, and for this he is remembered in the science‐religion community. Many people, however, are unaware of his exceptional career as a biochemist prior to his decision to pursue a life working as a clergyman in the Church of England. His contributions to studies of deoxyribonucleic acid (DNA) structure, effects of radiation damage on DNA, and on the interactions of DNA and proteins are among the most important in the field at the time and have had a lasting scientific impact that is still felt today. Peacocke's arguments with Jacques Monod over stochastic (chance) and deterministic (necessity) processes driving evolution became important independently for both the science and the religion communities and appear to have contributed significantly to his decision to become involved in science‐religion dialogue rather than continuing his work exclusively in the field of science. Nevertheless, although Peacocke took on an active church life and ceased his experimental work, he never left science but continued to read the scientific literature and published a scientific review on different approaches in defining DNA structure as recently as 2005.     

Correlates of changes in voluntary physical activity associated with the Youth Fit For Life intervention during after-school care

Overweight in youth is increasing and physical inactivity has been implicated as a causal factor. An after-school care intervention, Youth Fit For Life, has been associated with significant improvements in physiological factors and frequency of moderate-to-vigorous physical activity voluntarily completed outside of structured settings. Correlates of the observed changes in physical activity amounts were, however, unknown. A multiple regression equation with simultaneous entry of sex, age, race, initial Body Mass Index, and initial frequency of voluntary physical activity as predictor variables for changes in physical activity was calculated on Euro-American and African-American participants ages 8 to 12 years (N=217). A statistically significant 16% of the variance in changes in frequency of voluntary physical activity over 12 wk. was accounted for, with only voluntary physical activity at baseline and age making significant, unique contributions. For participants either overweight or at risk for overweight (n=72), the changes in physical activity significantly correlated with changes in Body Mass Index. Implications of findings to maximize treatment effects on voluntary physical activity were suggested.     

Do wild New Caledonian crows (<Emphasis Type="Italic">Corvus moneduloides</Emphasis>) attend to the functional properties of their tools?

New Caledonian crows are the most proficient non-hominin tool manufacturers but the cognition behind their remarkable skills remains largely unknown. Here we investigate if they attend to the functional properties of the tools that they routinely use in the wild. Pandanus tools have natural barbs along one edge that enable them to function as hooking implements when the barbs face backwards from the working tip. In experiment 1 we presented eight crows with either a non-functional (‘upside-down’) or a functional pandanus tool in a baited hole. Four of the crows never flipped the tools. The behaviour of the four flipping birds suggested that they had a strategy of flipping a tool when it was not working. Observations of two of the eight crows picking up pandanus tools at feeding tables in the wild supported the lack of attention to barb direction. In experiment 2 we gave six of the eight crows a choice of either a barbed or a barbless pandanus tool. Five of the crows chose tools at random, which further supported the findings in experiment 1 that the crows paid little or no attention to the barbs. In contrast, a third experiment found that seven out of eight crows flipped non-functional stick tools significantly more than functional ones. Our findings indicate that the crows do not consistently attend to the presence or orientation of barbs on pandanus tools. Successful pandanus tool use in the wild seems to rely on behavioural strategies formed through associative learning, including procedural knowledge about the sequence of operations required to make a successful pandanus tool. Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users.     

Learning from experience: Examining the impact of client work upon two trainee therapists

This qualitative research study, focusing on the learning and change of two trainee therapists over a nine‐month period, was conducted by the trainees themselves. In collecting and analysing their data, the researchers made use of the heuristic methodology, to which some of the principles of the co‐operative inquiry methodology were added. The findings shed light on some of the ways in which trainee counsellors and psychotherapists might learn through their work with clients, the forms and contexts in which this learning may arise, and how the learning might affect the trainees. The findings additionally highlight some of the possible benefits of engaging in research for trainee counsellors and psychotherapists, in terms of their roles as practitioners. These include positive changes in the ways in which they work with clients, and changes in the ways they think about their practice.     

From Sole Learning to Soul Learning

Abstract. Is it effective or even possible to teach an introductory course in religious studies that not only provides first‐year university students with the fundamental vocabulary, concepts, and critical tools of religious inquiry but also invites and stimulates the transformation of the religious imagination? In what kind of teaching and learning method could the process of personal transformation occur and how might one assess it? These are the questions that led to an experiment in teaching religion the objective of which was to prepare beginning students for the academic approach to religion and, at the same time, transmit the experience of learning as an embodied process that engages personal narrative within a community context. This essay is based on a three‐year project that has made considerable progress in meeting these goals and answering these questions. (Supplementary materials for this essay are available on the Wabash Center for Teaching and Learning in Theology and Religion web site http://www.wabashcenter.wabash.edu/journal/baldwin.html .)     

Virtual Reality Exposure Therapy for PTSD symptoms after a road accident: an uncontrolled case series

This report examined whether Virtual Reality Exposure Therapy (VRET) could be used in the treatment of posttraumatic stress disorder (PTSD) symptoms in the aftermath of a serious motor vehicle accident. Six individuals reporting either full or severe subsyndromal PTSD completed 10 sessions of VRET, which was conducted using software designed to create real-time driving scenarios. Results indicated significant reductions in posttrauma symptoms involving reexperiencing, avoidance, and emotional numbing, with effect sizes ranging from d=.79 to d=1.49. Indices of clinically significant and reliable change suggested that the magnitude of these changes was meaningful. Additionally, high levels of perceived reality ("presence") within the virtual driving situation were reported, and patients reported satisfaction with treatment. Results are discussed in light of the possibility for VRET to be useful in guiding exposure in the treatment of PTSD following road accidents.