增殖和凋亡的单独与联合检测对垂体瘤侵袭性诊断的价值

垂体瘤是颅内常见的良性肿瘸,但却存在着较高的复发率。Jefferson于1940年提出侵袭性垂体腺瘸的概念,认为这部分垂体腺瘤的生物学行为介于良性垂体瘤和垂体癌之间。随后人们从分子生物学、病理学等多个角度对侵袭性腺瘸的发病机制进行了探讨,以期寻找到特异性的侵袭性指标。众所周知,细胞增殖能力的增强和凋亡的抑制是导致肿瘤恶性生物学行为的重要机制。但对垂体瘤的研究却发现有为数不少的侵袭性垂体腺瘸并不呈现高细胞增殖状态。而凋亡的研究则更是出现了不同甚至相反的结果,那到底是什么原因导致了侵袭性的形成呢？本文从细胞增殖和凋亡各自的临床意义以及其联合检测的角度探讨侵袭性的确切机制。     

高等医学院校综合性通识课程内容的构建

21世纪是通识教育与专业教育逐步走向综合的世纪,而综合性通识课程内容的构建则是通识课程改革的关键.为了有助于我国医学院校构建综合性通识课程,通过对不同国家和地区综合性通识课程内容的组织、设计和实施的分析,探讨了高等医学院校综合性通识课程内容的构建.     

系统生物学——中西医结合的平台

通过比较系统生物学与中医理论在整体观、系统观、预测性和预防性医疗以及个体化治疗等方面的相似之处,并分析中医和西医各自的优点和不足,提出中医和现代医学在系统生物学的基础上进行整合的必然性和可能性,系统生物学是中西医结合的平台.     

团队异质性研究回顾与展望

从团队异质性的分类与测量、异质性的结果变量、异质性研究中的调节变量等方面阐述了团队异质性研究的成果和进展,并在此基础上讨论了未来研究的趋势和发展方向。未来的团队异质性研究需要对不同维度的异质性的交互作用进行分析;其次,异质性研究不仅要关注易观察特质的异质性,同时也需关注深层特质的异质性;最后,需要综合组织的背景,在更大的范围内研究异质性的影响     

Career-specific parental behaviors,career exploration and career adaptability: A three-wave investigation among Chinese undergraduates

The current research examined the effects of career-specific parental behaviors (reported by parents at time 1) on Chinese university students' career exploration (reported by students at time 2) and career adaptability (reported by students at time 3). A survey study was conducted among Chinese university graduates (N = 244) and their parents (N = 244). The results supported a mediation model such that a high level of parental support and a low level of parental interference had beneficial effects on Chinese undergraduates' career exploration, which in turn positively predicted their career adaptability. Lack of parental career engagement had a direct negative effect on career adaptability. Significant interaction effects were also found among these three types of parental behaviors such that at a lower level of lack of parental career engagement, the positive effects of parental support, as well as the negative effects of interference on career exploration were stronger. The corresponding moderated mediation models were also supported. These findings carry implications for research on career construction theory and career counseling practices.     

Does Socioeconomic Status Matter for Chinese Immigrants’ Academic Socialization? Family Environment,Parental Engagement,and Preschoolers’ Outcomes

Families’ academic socialization mediates how socioeconomic status (SES) affects children’s achievement. However, little is known about whether cultural values and family cohesion could buffer negative effects of low SES. We examined parental academic socialization and children’s achievement in 220 low- and middle-SES Chinese immigrant families with four-year-olds. Low-SES parents showed less stressful family environments and stronger beliefs about parental responsibility for education. However, middle-SES parents provided more reading engagement and enrichment activities. Reading engagement and SES were significantly associated with children’s academic performance. These findings demonstrate low-SES families’ strengths but suggest the need to provide more support for such families.