Effective brain connectivity in children with reading difficulties during phonological processing

Using Dynamic Causal Modeling (DCM) and functional magnetic resonance imaging (fMRI), we examined effective connectivity between three left hemisphere brain regions (inferior frontal gyrus, inferior parietal lobule, fusiform gyrus) and bilateral medial frontal gyrus in 12 children with reading difficulties (M age=12.4, range: 8.11-14.10) and 12 control children (M age=12.3, range: 8.9-14.11) during rhyming judgments to visually presented words. More difficult conflicting trials either had similar orthography but different phonology (e.g. pint-mint) or similar phonology but different orthography (e.g. jazz-has). Easier non-conflicting trials had similar orthography and phonology (e.g. dime-lime) or different orthography and phonology (e.g. staff-gain). The modulatory effect from left fusiform gyrus to left inferior parietal lobule was stronger in controls than in children with reading difficulties only for conflicting trials. Modulatory effects from left fusiform gyrus and left inferior parietal lobule to left inferior frontal gyrus were stronger for conflicting trials than for non-conflicting trials only in control children but not in children with reading difficulties. Modulatory effects from left inferior frontal gyrus to inferior parietal lobule, from medial frontal gyrus to left inferior parietal lobule, and from left inferior parietal lobule to medial frontal gyrus were positively correlated with reading skill only in control children. These findings suggest that children with reading difficulties have deficits in integrating orthography and phonology utilizing left inferior parietal lobule, and in engaging phonological rehearsal/segmentation utilizing left inferior frontal gyrus possibly through the indirect pathway connecting posterior to anterior language processing regions, especially when the orthographic and phonological information is conflicting.     

不同符号形式数字的数量表征

针对以往对不同符号形式数字数量表征的ERP研究只应用以反应为原点分段平均分析方法,以及忽略对后期符号效应观察,从而造成对数量表征的考察不完善的状况,本研究利用ERP技术,结合借助潜伏期平移思想的以刺激为原点的分段平均方法,对阿拉伯与汉字小写的两位数数字的数量大小比较任务进行考察.结果表明阿拉伯数字与汉字数字在编码表征阶段存在差异,ERP结果中符号效应与距离效应无交互作用,但是在距离效应出现的同时仍然存在符号效应,说明不同符号形式数字的数量表征并非完全相同.     

视觉归纳概括的加工机制与策略

给22名被试呈现若干组在外形与纹路上变化的电池图片,要求指出何种类型的电池有电.结果发现,被试会快速觉察电池的共享特征并概括出一般性的结论.如若电池间无共享特征,被试则需较长时间才给出"无法概括"的反应.共享纹路时,被试在"共享-无干扰"条件下的反应明显快于 "共享- 有干扰"条件下的反应,体现出假设形成与验证的过程.共享特征为外形的反应时短于共享特征为纹路的反应时 ,这说明被试在任务中采用的是整体优先的加工策略.     

同步内隐／外显序列学习：事件相关的fMRI的初步研究

本文利用事件相关fMRI研究探讨对于内隐和外显学习在脑区激活上的差异.实验采用同步内隐/外显学习序列,以有色的形状作为刺激材料.要求被试对于刺激的颜色做选择反应,并在颜色消失后找出形状的内在规则.颜色和图形序列分别采用两个独立的马尔可夫链,即下一个图形的颜色或者形状有70%的可能服从序列规则.行为数据显示被试习得了外显和内隐的规则,fMRI成像主要比较内隐和外显学习在学习过程和知识运用上脑区激活的差异.结果发现,与内隐学习柑比,外显学习在额叶的激活更为显著.而且,内隐学习和外显学习在视觉皮层的激活出现分离,内隐学习中枕叶的激活减弱,而外显学习中枕叶的激活增加.     

简单结构刺激非规则特征突显条件下的样例效应

用变化了的Allen和Brooks的实验范式,采用2(学习轮次:5轮、10轮)×2(项目类型:旧项目、新项目)×2(项目匹配性质:正向匹配、反向匹配)混合实验设计,研究对4个特征刺激分类时非规则特征突显条件下的样例效应。结果发现,无论是错误率还是反应时都取得了明显的样例效应,但是学习时间的影响不明显。     

Affective and cognitive meta-bases of attitudes: Unique effects on information interest and persuasion

The authors investigated the predictive utility of people's subjective assessments of whether their evaluations are affect- or cognition driven (i.e., meta-cognitive bases) as separate from whether people's attitudes are actually affect- or cognition based (i.e., structural bases). Study 1 demonstrated that meta-bases uniquely predict interest in affective versus cognitive information above and beyond structural bases and other related variables (i.e., need for cognition and need for affect). In Study 2, meta-bases were shown to account for unique variance in attitude change as a function of appeal type. Finally, Study 3 showed that as people became more deliberative in their judgments, meta-bases increased in predictive utility, and structural bases decreased in predictive utility. These findings support the existence of meta-bases of attitudes and demonstrate that meta-bases are distinguishable from structural bases in their predictive utility.     

从李丽云事件看生命健康权、患者自主权和医生干涉权

当患方行使自主权所做的决定危及自身生命健康权时,能否赋予医生干涉权以实现生命高于一切的理念？阐明了生命健康权、患者自主权和医生干涉权的关系．并从我国实际出发,论述不能通过赋予医生干涉权来避免类似李丽云悲剧的发生,建议立法完善对民事行为能力的规定,建立司法机关或其他第三方机构提前快速审查机制来解决自主权与生命权的冲突。     

患者隐私杈的法学思考

结合法学理论、医疗实践和目前患者隐私权的法律保护现状,就侵权行为、民事责任的认定以及隐私权的限制等问题予以理论阐释,并提出了切实可行的保护措施,如建立健全相关法律法规、医务人员要增强法律保护意识等,以期为患者隐私权的保护提供有益的参考。     

先进文化的大众化和社会动员--兼论中国先进文化的前进历程

中国社会的现代化有自身的先进文化启动与文化自觉,新中国实现过文化的大众化动员,改革开放后商品经济的大发展和市场体系的逐步建立,促进了社会生活模式和精神文化的巨大变迁,然而文化变革与政治、经济领域的发展并不完全同步。先进文化和新道德、新风尚的全面形成往往需要一个过程,这个过程的长短既取决于新的先进的领航文化的自觉程度,又取决于新文化对整个社会的动员能力。新旧文化之间激烈的碰撞和冲突,必然需要相应的社会宏观调控,制定出有效的文化规范。     

从"历史先天"来看福柯的知识考古学

该文试图考察福柯的自律的话语理论并反思考古学的症结。文章从“历史先天”这一关键词出发,阐述福柯的知识考古学如何将对话语的实证描述和探索话语构成的先天规则结合起来,从而保证其在对话语的形式分析的同时,超越传统哲学深陷其中的三对矛盾：“经验-先验”、“我思-未思”、“本源的隐退-回归”。围绕着“陈述”的三个特性,我们可以看到福柯为此所做的努力,即打通共时与历时之隔,经验与先验之分,实现结构主义和实证主义的联姻。文章最后指出这种自律的话语理论的症结所在,认为福柯并没有如愿以偿地跳出“有限性解析”的窠臼。