Effects of Acute Stress or Centrally Injected Interleukin-1beta on Neuropeptide Expression in the Immune System

Acute stress stimulates the expression and release of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) from the hypothalamus, and the pro-opiomelanocortin products beta-endorphin and ACTH from the anterior pituitary. These neuropeptides are also expressed in immune tissues, and it has been proposed that they may modulate immune responses to stress through paracrine mechanisms. We subjected rats to restraint stress or central injection of interleukin (IL)-1beta to determine whether these acute stimuli can alter the expression of neuropeptides in the spleen and thymus. Restraint stress significantly increased the contents of all these neuropeptides in thymic, but not splenic, extracts. A single icv injection of IL-1beta increased contents of CRH, AVP, ACTH and beta-endorphin in the spleens of both sham-operated and adrenalectomised (ADX) rats. IL-1beta increased thymic contents of CRH and ACTH in sham-operated rats but these increases were not observed in ADX rats. These results suggest that the effects of IL-1beta on neuropeptide expression in the spleen are independent of glucocorticoids, whereas IL-1beta stimulation of neuropeptide expression in the thymus is dependent on circulating glucocorticoids. There were significant correlations between increases in CRH, ACTH and beta-endorphin in the spleen, and between CRH and ACTH in the thymus, consistent with the suggestion that IL-1beta-induced increases in ACTH and beta-endorphin may be mediated through CRH. These results provide evidence that stressors can directly influence neuropeptide expression in immune tissues. Thus stress may influence immune functions through paracrine mechanisms involving locally synthesised neuropeptides as well as through activation of the hypothalamo-pituitary-adrenal axis.     

Remembering plurals: Unit of coding and form of coding during serial recall

Subjects were required to recall lists of six words which had been presented visually in sequence. One or two of the words might be plural nouns. A substantial number of errors occurred in which the plural form became detached from its original root. This is taken as evidence for a morpheme-based code as opposed to a unitary word code. A significantly high proportion of these errors maintained the form of the plural ( /S/, /Z/ or (ЪZ/) which is considered evidence for a primarily phonological coding of the plural morpheme. There is however a suggestion that on some occasions the plural is coded morphemically—i.e., in a way which does not distinguish between the various plural endings.     

Assessing Facets of Mindfulness in the Context of Work: The Mindfulness@Work Scale as a Work-Specific,Multidimensional Measure of Mindfulness

The mindfulness at work literature lacks a multi-faceted measure of mindfulness that is applicable in the work context. Building on predominantly clinically oriented, multi-faceted mindfulness measures, we aimed to develop and validate such a measure and to provide first insights into differential validities of mindfulness subfacets for work outcomes. Data from seven work samples (overall n = 4,977) provided support that (a) a 4-factor structure representing the subfacets of Describing, Nonreactivity, Nonjudging, and Act with Awareness replicates across samples; (b) subfacets and overall scale have good internal consistency and retest reliability; (c) the measure demonstrates convergent and discriminant validity; (d) it demonstrates criterion-related validity for well-being, motivational, and interpersonal work outcomes; (e) the Mindfulness@Work Scale explains variance in outcome variables above a unidimensional measures of mindfulness supporting its incremental validity. Furthermore, relative weights and incremental validity analyses revealed differential validities of subfacets of the Mindfulness@Work Scale in relation to positive psychological states versus psychological distress. Overall, findings suggest that the Mindfulness@Work Scale has good psychometric properties and that a differentiation of subfacets provides novel insights into the role of mindfulness for work outcomes.     

Spirituality in Clinical Practice: The Perspective of Brazilian Medical Students

Journal of Religion and Health - The purpose of this study was to evaluate the beliefs, opinions, and experiences of medical students from a Catholic confessional university concerning spirituality...     

Assessment of Executive Functions after Treatment of Childhood Acute Lymphoid Leukemia: a Systematic Review

Neuropsychology Review - Individuals treated for childhood acute lymphoblastic leukemia (ALL) have a high survival rate. This fact, however, may lead to neurocognitive impairments in survivors, as...     

Hippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts

Rats have a natural tendency to spend more time exploring novel objects than familiar objects, and this preference can be used as an index of object recognition. Rats also show an exploratory preference for objects in locations where they have not previously encountered objects (an index of place memory) and for familiar objects in contexts different from those in which the objects were originally encountered (an index of context memory). In this experiment, rats with cytotoxic lesions of the hippocampal formation were tested on all three versions of the novelty-preference paradigm, with a 5-min retention interval between the familiarization and test phases. Rats with sham lesions displayed a novelty preference on all three trial types, whereas the rats with hippocampal lesions displayed a novelty preference on Object trials but did not discriminate between the objects on Place trials or Context trials. The findings indicate that hippocampal damage impairs memory for contextual or spatial aspects of an experience, whereas memory for objects that were part of the same experience are left relatively intact.     

Orientational manoeuvres in the dark: dissociating allocentric and egocentric influences on spatial memory

Subjects in a darkroom saw an array of five phosphorescent objects on a circular table and, after a short delay, indicated which object had been moved. During the delay the subject, the table or a phosphorescent landmark external to the array was moved (a rotation about the centre of the table) either alone or together. The subject then had to indicate which one of the five objects had been moved. A fully factorial design was used to detect the use of three types of representations of object location: (i) visual snapshots; (ii) egocentric representations updated by self-motion; and (iii) representations relative to the external cue. Improved performance was seen whenever the test array was oriented consistently with any of these stored representations. The influence of representations (i) and (ii) replicates previous work. The influence of representation (iii) is a novel finding which implies that allocentric representations play a role in spatial memory, even over short distances and times. The effect of the external cue was greater when initially experienced as stable. Females out-performed males except when the array was consistent with self-motion but not visual snapshots. These results enable a simple egocentric model of spatial memory to be extended to address large-scale navigation, including the effects of allocentric knowledge, landmark stability and gender.