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11.
Hippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts 总被引:8,自引:1,他引:7 下载免费PDF全文
Mumby DG Gaskin S Glenn MJ Schramek TE Lehmann H 《Learning & memory (Cold Spring Harbor, N.Y.)》2002,9(2):49-57
Rats have a natural tendency to spend more time exploring novel objects than familiar objects, and this preference can be used as an index of object recognition. Rats also show an exploratory preference for objects in locations where they have not previously encountered objects (an index of place memory) and for familiar objects in contexts different from those in which the objects were originally encountered (an index of context memory). In this experiment, rats with cytotoxic lesions of the hippocampal formation were tested on all three versions of the novelty-preference paradigm, with a 5-min retention interval between the familiarization and test phases. Rats with sham lesions displayed a novelty preference on all three trial types, whereas the rats with hippocampal lesions displayed a novelty preference on Object trials but did not discriminate between the objects on Place trials or Context trials. The findings indicate that hippocampal damage impairs memory for contextual or spatial aspects of an experience, whereas memory for objects that were part of the same experience are left relatively intact. 相似文献
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Orientational manoeuvres in the dark: dissociating allocentric and egocentric influences on spatial memory 总被引:2,自引:0,他引:2
Subjects in a darkroom saw an array of five phosphorescent objects on a circular table and, after a short delay, indicated which object had been moved. During the delay the subject, the table or a phosphorescent landmark external to the array was moved (a rotation about the centre of the table) either alone or together. The subject then had to indicate which one of the five objects had been moved. A fully factorial design was used to detect the use of three types of representations of object location: (i) visual snapshots; (ii) egocentric representations updated by self-motion; and (iii) representations relative to the external cue. Improved performance was seen whenever the test array was oriented consistently with any of these stored representations. The influence of representations (i) and (ii) replicates previous work. The influence of representation (iii) is a novel finding which implies that allocentric representations play a role in spatial memory, even over short distances and times. The effect of the external cue was greater when initially experienced as stable. Females out-performed males except when the array was consistent with self-motion but not visual snapshots. These results enable a simple egocentric model of spatial memory to be extended to address large-scale navigation, including the effects of allocentric knowledge, landmark stability and gender. 相似文献
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Hugo?WesterlundEmail author Anna?Bergstr?m T?res?Theorell 《Integrative psychological & behavioral science》2004,39(1):3-15
Thirty-two female participants in a mobilising labour market programme offering temporary, alternative employment in Sweden
were followed longitudinally for one year, including a six month post participation follow-up period. It can be hypothesised
that an important aspect of the physiological effects of unemployment is a change in the balance between anabolic and catabolic
activities in the body and that re-employment should lead to a shift towards anabolism. An earlier study of a smaller subset
of the data, however, including both men and women, showed increased prolactin and decreased dehydroepiadrosterone sulphate
(DHEA-s) levels, contrary to the initial hypothesis. In the present analysis, intended to elucidate these results, psychophysiological
data were summarised in two indices, one connected with anabolism (made up of testosterone and DHEA-s) and one with catabolism
(prolactin, γ-glutamyl transferase, aspartate amino transferase, α levuline amino transferase, and body mass index). In addition,
self-rated anxiety, depression, hopelessness and personal control were analysed. The results indicate that the effect of ‘better’
activities within the programme was a temporary increase in anabolism, possibly indicating lower stress levels, and the effect
of ‘worse’ activities, on the one hand, a temporary decrease in the catabolic index, probably reflecting repressed alcohol
consumption, and, on the other hand, impaired anabolism. There was also a general but transient decrease in depressiveness
measured by the Hospital Anxiety and Depression Scale. The results seem to imply that it is difficult to achieve lasting effects
through a relatively short participation in a mobilising programme. 相似文献
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Group discussion significantly improves performance on intellective problems. However, most experiments have been conducted in Western cultures. Cross‐cultural psychology suggests that members of Eastern cultures might be less likely to benefit from group discussion. One experiment in Japan suggested that this was not the case, but this experiment suffered from some limitations. To address these limitations, Japanese participants were asked to solve an intellective task four times: individually (pre‐test), in small discussion groups (test), individually again (transfer task, post‐test), and individually after a delay (delayed post‐test). The results revealed a robust improvement during group discussion. Groups in which at least one member had found the correct answer individually agreed on it during the discussion. Moreover, and in contrast with results obtained in Western cultures, most groups with no such member also found the correct answer. The gains obtained during discussion were maintained in the transfer tasks. This result provides further evidence that the improvement of reasoning performance in group discussion is a universal phenomenon, and provides support for the practice of collaborative learning in Japan. 相似文献
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Familial processes are gaining an increased amount of attention in cognitive behavioural therapy. Their role in initiating, maintaining, and exacerbating distress in children and adolescents has clear clinical implications. Therefore, including parents in their children’s therapy sessions as coaches, collaborators, and co-patients is becoming commonplace in CBT approaches to internalizing disorders such as anxiety. This article describes a case of a 13?year old female who presented with features of Generalized Anxiety Disorder and Separation Anxiety whose course of treatment involved her mother as a coach, collaborator and co-patient. A case formulation is offered and the specific examples of CBT practices used in each session are detailed. Ways of evaluating treatment outcome are also discussed. 相似文献