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301.
Yoshimoto S Cerjak D Babygirija R Bulbul M Ludwig K Takahashi T 《Stress (Amsterdam, Netherlands)》2012,15(2):227-236
Although acute stress accelerates colonic transit, the effect of chronic stress on colonic transit remains unclear. In this study, rats received repeated restraint stress (chronic homotypic stress) or various types of stress (chronic heterotypic stress) for 5 and 7 days, respectively. Vehicle saline, oxytocin (OXT), OXT receptor antagonist or corticotropin-releasing factor (CRF) receptor antagonists were administered by intracerebroventricular (ICV) injection prior to restraint stress for 90 min. Immediately after the stress exposure, the entire colon was removed and the geometric center (GC) of Na51CrO4 (a nonabsorbable radioactive marker; 0.5 μCi) distribution was calculated to measure the transit. Gene expression of OXT and CRF in the paraventricular nucleus (PVN) was evaluated by in situ hybridization. Accelerated colonic transit with the acute stressor was no longer observed following chronic homotypic stress. This restored colonic transit was reversed by ICV injection of an OXT antagonist. In contrast, chronic heterotypic stress significantly accelerated colonic transit, which was attenuated by ICV injection of OXT and by a CRF receptor 1 antagonist. OXT mRNA expression in the PVN was significantly increased following chronic homotypic stress, but not chronic heterotypic stress. However, CRF mRNA expression in the PVN was significantly increased following acute and chronic heterotypic stress, but not chronic homotypic stress. These results indicate that central OXT and CRF play a pivotal role in mediating the colonic dysmotility following chronic stress in rats. 相似文献
302.
Domestic dogs (Canis familiaris) have been shown to actively initiate triadic communicative interactions by looking at a human partner or by alternating
their gaze between the human and an object when being faced with an out-of-reach reward or an unsolvable problem. It has hardly
been investigated, however, whether dogs flexibly adjust their human-directed behavior to the actions of their partners, which
indicate their willingness and abilities to help them when they are faced with a problem. Here, in two experiments, we confronted
dogs—after initially allowing them to learn how to manipulate an apparatus—with two problem situations: with an empty apparatus
and a blocked apparatus. In Experiment 1, we showed that dogs looked back at their owners more when the owners had previously
encouraged them, independently from the problem they faced. In Experiment 2, we provided dogs with two experimenters and allowed
them to learn through an initial phase that each of the experimenters could solve one of the two problems: the Filler re-baited
the empty apparatus and the Helper unblocked the blocked apparatus. We found that dogs could learn to recognize the ability
of the Filler and spent time close to her when the apparatus was empty. Independently from the problem, however, they always
approached the Helper first. The results of the present study indicate that dogs may have a limited understanding of physical
problems and how they can be solved by a human partner. Nevertheless, dogs are able to adjust their behavior to situation-specific
characteristics of their human partner’s behavior. 相似文献
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304.
Stephanie Merritt Kelli Huber Timothy Bartkoski 《The journal of positive psychology》2019,14(1):113-124
ABSTRACTEach individual possesses character strengths, the most significant of which are classified as signature strengths. With a sample of 164 individuals who were employed at least part-time in a variety of industries, we examined application of signature strengths and well-being both between-persons (global) and within-persons (daily). Global application of signature strengths was associated with global job satisfaction and strain; however, no significant mediation effects on intent to turnover were found. We also found that daily variations in application of signature strengths were related to daily job satisfaction and strain. Common method bias associated with trait positive and negative affect differed by level of analysis: At the between-person (global) level, trait affect produced substantial inflation of estimates, but at the within-person (daily) level, inflation was negligible. The results suggest the importance of daily opportunities to apply signature strengths and of accounting for variance attributable to trait affect in between-person analyses. 相似文献
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