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241.
Kuo YM Liang KC Chen HH Cherng CG Lee HT Lin Y Huang AM Liao RM Yu L 《Neurobiology of learning and memory》2007,87(1):93-100
Context-induced drug craving and continuous drug use manifest the critical roles of specific memory episodes associated with the drug use experiences. Drug-induced conditioned place preference (CPP) in C57BL/6J mouse model, in this regard, is an appropriate behavioral paradigm to study such drug use-associated memories. Requirement of protein synthesis in various forms of long-term memory formation and storage has been phylogenetically demonstrated. This study was undertaken to study the requirement of protein synthesis in the learning and memory aspect of the conditioned place preference induced by cocaine and methamphetamine, two abused drugs of choice in local area. Since pCREB has been documented as a candidate substrate for mediating the drug-induced neuroadaptation, the pCREB level in hippocampus, nucleus accumbens, and prefrontal cortex was examined for its potential participation in the formation of CPP caused by these psychostimulants. We found that cocaine (2.5 and 5.0 mg/kg/dose)-induced CPP was abolished by the pretreatment of anisomycin (50 mg/kg/dose), a protein synthesis inhibitor, whereas methamphetamine (0.5 or 1.0 mg/kg/dose)-induced CPP was not affected by the anisomycin pretreatment. Likewise, cocaine-induced CPP was mitigated by another protein synthesis inhibitor, cycloheximide (15 mg/kg/injection) pretreatment, whereas methamphetamine-induced CPP remained intact by such pretreatment. Moreover, anisomycin treatment 2h after each drug-place pairing disrupted the cocaine-induced CPP, whereas the same treatment did not affect methamphetamine-induced CPP. An increase of accumbal pCREB level was found to associate with the learning phase of cocaine, but not with the learning phase of methamphetamine. We further found that intraaccumbal CREB antisense oligodeoxynucleotide infusion diminished cocaine-induced CPP, whereas did not affect the methamphetamine-induced CPP. Taken together, these data suggest that protein synthesis and accumbal CREB phosphorylation are essential for the learning and consolidation of the cocaine-induced CPP, whereas methamphetamine-induced CPP may be unrelated to the synthesis of new proteins. 相似文献
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Insight into neuromuscular control of movement is gained through an understanding of the mechanical causes of movement. Data on new walkers' net joint moments is scarce, however, although those moments can be considered the direct cause of movement. The authors' goal in this research project was to characterize net joint moments in toddlers (N = 10) during the first 5 months of independent walking and to discuss their role in mechanical control of walking. The authors modeled leg segments as oscillating pendulums fixed at the proximal joint and investigated the relationship between force and movement. Their investigation revealed that at the onset of independent gait, walking was primarily hip driven. Furthermore, the toddlers seemed to experience problems in uncoupling active and passive control around the joints. Changes in mechanical control of walking were observed after 3 to 4 months of independent walking. The changes were more obvious at the hip and the knee joint than at the ankle. 相似文献
243.
Hui-Jen Yang Yun-Long Lay Wen-Yu Tsao Yi-Chin Liou Cheng-Kun Lin 《Cyberpsychology & behavior》2007,10(2):226-233
Language interface plays a critical role as the foundation of communication. Possessing greater fluency in the host language can lead to increased opportunities for interaction with host members. This research is to examine the impact of language and Internet usage anxiety and self-efficacy on the intended uses of Internet sites, respectively. By the same token, whether Internet/language self-efficacy would mediate the effects of Internet/language anxiety on the intention of the Internet site use is also examined. A valid sample of 368 undergraduates was tested in this study. The path analysis results mostly supported the model tested. The results display that the anxiety of language and Internet use have significantly influenced self-efficacy of Internet use and language, respectively. Anxiety about language and Internet use have also significantly influenced the intention to use Internet sites individually. Furthermore, language self-efficacy has significantly influenced the intention to use Internet sites, but Internet self-efficacy has not. The implications are discussed at the end of the paper. 相似文献
244.
Chien-Huang Lin Pei-Hsun Wu Shih-Chieh Chuang Danny T. Kao 《Asian Journal of Social Psychology》2007,10(3):179-187
Prior research seems to have neglected the factors that influence consumers to use price information as an indicator of quality or sacrifice. Based on the concept of 'goal looms larger', Study 1 in the present research demonstrated that the extent to which consumers use price information as an indicator of quality or sacrifice is a function of consumer goal (promotion focus vs prevention focus). Study 2 demonstrated that extremeness aversion is a function of consumer goal. The extent of extremeness aversion is significantly greater for prevention-focused consumers than for promotion-focused consumers. 相似文献
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任务切换是执行控制的一种重要功能。切换代价是量化执行控制持续时间的指标。并广泛应用于各个研究领域。但是切换代价在多大程度上体现了执行控制的作用,仍然还存在争论.当前主要存在任务设置重构、任务设置惯性和联结竞争三种理论。本文首先介绍了三种理论的基本观点和实验证据,以及对任务切换加工机制的分析;其次阐明了对三种理论进行整合的相关研究;最后分析了进一步研究的方向。 相似文献
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类别不确定下的特征推理是基于类别还是基于特征联结 总被引:1,自引:0,他引:1
共有3个实验探讨归类不确定情况下的特征推理是基于类别进行还是基于特征联结进行。实验1在中文条件下重复了Verde等人2005的实验,得出了与之相符的结果,这个结果用基于类别的理性模型的设想或者是用基于特征联结的设想都可以解释。实验2考察被试在靶类别的类别特征频次并且特征结合出现频次高低不同的条件下特征推理的情况,实验2的结果表明,高集中与低集中两种条件下特征推理没有显著差异,不符合特征推理是基于类别进行的设想,而与特征推理是基于特征联结进行的设想吻合。实验3进一步考察被试在特征结合出现的总频次并且靶类别中特征结合出现的总频次高低不同的条件下特征推理的情况,结果表明,在高结合条件下进行特征推理要优于在低结合条件,支持了在归类不确定情况下的特征推理是基于特征联结进行的设想。据此可以认为,人们的特征推理是基于特征之间联结的频次进行,而不是基于类别进行 相似文献