The Three Rs of Animal Research: What they Mean for the Institutional Animal Care and Use Committee and Why

The Institutional Animal Care and Use Committee (IACUC) is entrusted with assessing the ethics of proposed projects prior to approval of animal research. The role of the IACUC is detailed in legislation and binding rules, which are in turn inspired by the Three Rs: the principles of Replacement, Reduction, and Refinement. However, these principles are poorly defined. Although this provides the IACUC leeway in assessing a proposed project, it also affords little guidance. Our goal is to provide procedural and philosophical clarity to the IACUC without mandating a particular outcome. To do this, we analyze the underlying logic of the Three Rs and conclude that the Three Rs accord animals moral standing, though not necessarily “rights” in the philosophical sense. We suggest that the Rs are hierarchical, such that Replacement, which can totally eliminate harm, should be considered prior to Reduction, which decreases the number of animals harmed, with Refinement being considered last. We also identify the need for a hitherto implicit fourth R: Reject, which allows the IACUC to refuse permission for a project which does not promise sufficient benefit to offset the pain and distress likely to be caused by the proposed research.     

Cautious Defection: Group Representatives Cooperate and Risk Less than Individuals

Individuals often make decisions that affect groups, yet the propensities of group representatives are not as well understood than those of independent decision makers or deliberating groups. We ask how responsibility for group payoffs—in the absence of group deliberation—affects the choice. The experiment utilizes the Interdependent Security Dilemma paradigm. In its deterministic version, the game is identical to a finitely repeated Prisoner's Dilemma. In the stochastic version, potential losses are larger but uncertain, occurring with a predefined probability when one or both players choose to forgo investment in protection. Participants were assigned to play either as individuals, or as representatives of three‐person groups, with each member's choices equally likely to determine the group's payoffs. In the deterministic condition, individuals were more likely to invest (cooperate) than group representatives (80% vs. 62% of rounds). In the stochastic condition, the pattern was reversed as representatives were slightly, but not significantly, more likely to invest than individuals (46% vs. 40%). The significant interaction effect suggested that group representatives were not only less cooperative but also more risk averse than individuals. A follow‐up study supported this account by showing participants who construed the invest strategy as low‐risk than those who perceived this strategy to be high risk. Overall, group representatives exhibited a tendency to act more competitively and more cautiously than individuals acting alone. Copyright © 2015 John Wiley & Sons, Ltd.     

The Relationship Between Right‐wing Attitudes and Cognitive Style: A Comparison of Self‐report and Behavioural Measures of Rigidity and Intolerance of Ambiguity

Two recent meta‐analytic studies addressing the relationship between cognitive style and right‐wing attitudes yielded some discrepancies. We argue that these discrepancies can be accounted for when one considers the types of cognitive style measures included in those analyses. One of these analyses primarily relied on self‐report measures, whereas the other relied on behavioural measures of cognitive style. Based on a new meta‐analysis of 103 samples (total N = 12 714) focussing on behavioural and self‐report measures of rigidity and intolerance of ambiguity, we confirmed the hypothesis that self‐report scales yield stronger relationships with right‐wing attitudes than behavioural measures. We point out potential conceptual and validity issues with both types of cognitive style measures and call for cautiousness when interpreting the magnitude of their relationships with ideology. Copyright © 2016 European Association of Personality Psychology     

Task-related functional connectivity of the caudate mediates the association between trait mindfulness and implicit learning in older adults

Accumulating evidence shows a positive relationship between mindfulness and explicit cognitive functioning, i.e., that which occurs with conscious intent and awareness. However, recent evidence suggests that there may be a negative relationship between mindfulness and implicit types of learning, or those that occur without conscious awareness or intent. Here we examined the neural mechanisms underlying the recently reported negative relationship between dispositional mindfulness and implicit probabilistic sequence learning in both younger and older adults. We tested the hypothesis that the relationship is mediated by communication, or functional connectivity, of brain regions once traditionally considered to be central to dissociable learning systems: the caudate, medial temporal lobe (MTL), and prefrontal cortex (PFC). We first replicated the negative relationship between mindfulness and implicit learning in a sample of healthy older adults (60–90 years old) who completed three event-related runs of an implicit sequence learning task. Then, using a seed-based connectivity approach, we identified task-related connectivity associated with individual differences in both learning and mindfulness. The main finding was that caudate-MTL connectivity (bilaterally) was positively correlated with learning and negatively correlated with mindfulness. Further, the strength of task-related connectivity between these regions mediated the negative relationship between mindfulness and learning. This pattern of results was limited to the older adults. Thus, at least in healthy older adults, the functional communication between two interactive learning-relevant systems can account for the relationship between mindfulness and implicit probabilistic sequence learning.     

Suggested behavioral interventions in the classroom to assist students prenatally exposed to drugs

The population of children exposed prenatally to alcohol, cocaine, methamphetamine, and other legal or illegal substances has been rapidly growing in America. The known characteristics of this group include deficits in rule-governed behavior, impulsivity, attention to task, language, sleep attachment, learning, social competence, coordination, hypersensitivity to environmental stimuli, and conduct problems. The purpose of this paper was to describe the characteristics of this population and match known, empirically demonstrated, data-based strategies, such as teacher attention and praise, token reinforcement programs, daily report cards, contingency contracting, self-instructional training, self-management, peer tutoring, Direct Instruction, and combining behavior therapy with stimulant medication therapy, to specific academic and social deficits in children with parental histories of substance abuse. © 1998 John Wiley & Sons, Ltd.     

Explaining Math: Gesturing Lightens the Load

Why is it that people cannot keep their hands still when they talk? One reason may be that gesturing actually lightens cognitive load while a person is thinking of what to say. We asked adults and children to remember a list of letters or words while explaining how they solved a math problem. Both groups remembered significantly more items when they gestured during their math explanations than when they did not gesture. Gesturing appeared to save the speakers' cognitive resources on the explanation task, permitting the speakers to allocate more resources to the memory task. It is widely accepted that gesturing reflects a speaker's cognitive state, but our observations suggest that, by reducing cognitive load, gesturing may also play a role in shaping that state.     

Age of acquisition and imageability ratings for a large set of words, including verbs and function words

Age of acquisition and imageability ratings were collected for 2,645 words, including 892 verbs and 213 function words. Words that were ambiguous as to grammatical category were disambiguated: Verbs were shown in their infinitival form, and nouns (where appropriate) were preceded by the indefinite article (such asto crack anda crack). Subjects were speakers of British English selected from a wide age range, so that differences in the responses across age groups could be compared. Within the subset of early acquired noun/verb homonyms, the verb forms were rated as later acquired than the nouns, and the verb homonyms of high-image ability nouns were rated as significantly less imageable than their noun counterparts. A small number of words received significantly earlier or later age of acquisition ratings when the 20–40 years and 50–80 years age groups were compared. These tend to comprise words that have come to be used more frequently in recent years (either through technological advances or social change), or those that have fallen out of common usage. Regression analyses showed that although word length, familiarity, and concreteness make independent contributions to the age of acquisition measure, frequency and imageability are the most important predictors of rated age of acquisition.     

A proposed adaptation of DC: 0‐3R for primary care,developmental research,and prevention of mental disorders

The development of the Diagnostic Classification of Mental Health and Developmental Disorders of Infancy and Early Childhood (DC: 0‐3; Zero to Three: National Center for Clinical Infant Programs, 1994) has been an important step in the field of infant mental health. In this paper, we propose some additions to the existing classification system. These additions include the development of criteria for infant, toddler, and family strengths, and the development of criteria for symptomatology that represents risk for disorder, but not fully manifest disorder. These additions will give DC: 0‐3R greater potential for use in the primary health care of children, thereby increasing the system's utility in diagnosing and preventing infant mental health problems.     

A theory of the visual system biology underlying development of spatial frequency lateralization

The spatial frequency hypothesis contends that performance differences between the hemispheres on various visuospatial tasks are attributable to lateralized processing of the spatial frequency content of visual stimuli. Hellige has proposed that such lateralization could arise during infant development from the earlier maturation of the right hemisphere combined with the increasing sensitivity of the visual system to high spatial frequencies. This proposal is intuitively appealing but lacks an explicit theory with respect to the underlying visual system biology. In this paper, we develop such a theory based on knowledge of visual system processing and development. We then translate our theory into a computational model that serves as the basis for a series of development simulations. We find that the simulations produce spatial frequency lateralization effects consistent with those observed empirically. We relate the nature of the neural asymmetry implied by our theory to empirical findings on visual pathway bias and the relative spatial frequency lateralization effect.