Rigidity in social and emotional memory in the R6/2 mouse model of Huntington's disease

Four experiments were conducted to examine social and emotional memory in the R6/2 transgenic mouse model of Huntington’s disease. First, R6/2 mice were tested in a social transmission of food preference task where they had to acquire a preference for a flavoured food (acquisition) and subsequently to learn a preference for a different flavour (shifted reinforcement). R6/2 mice performed well in the acquisition trial. However, they were impaired in the shifted reinforcement trial and perseverated on the first preference learned. Second, mice were trained in an inhibitory avoidance paradigm, with either one or two footshocks delivered during the training. WT mice given one footshock showed retention levels lower than those of mice trained with two footshocks. By contrast, there was no difference in retention levels of R6/2 mice given either one or two footshocks. Third, mice were tested in an active avoidance task that paired a mild footshock with a warning light. R6/2 mice had a strong age-dependent deficit in this task. Finally, mice were tested in a conditioned taste aversion task that paired a saccharine solution with a nausea-inducing agent (LiCl). R6/2 mice displayed normal aversion, however this was not extinguished following repeated exposure to saccharine solution alone. Our data show that while R6/2 mice have functional hippocampus-based memory, they have deficits in striatum-based memory skills. Further, social and emotional memories appear to be encoded in a rigid way that is not influenced by subsequent learning or by arousal levels.     

We Value What Values Us: The Appeal of Identity-Affirming Science

Members of the public (Study 1; n =  184) and university students (Study 2; n =  101) evaluated a piece of research and indicated their support for its continuation. The research findings were held constant, but the methods that revealed those findings were attributed to either neuroscience or social science, and the conclusions based on those findings were biased either in favor of men or in favor of women. Study 1 revealed that participants were more positive about research that affirmed their gender identity and that was based on neuroscience rather than social science. Study 2 found this pattern to be apparent in more specialist samples. Indeed, participants with some scientific training were more influenced by research that affirmed the reader's gender identity. Participants with less scientific training, in comparison, were more influenced by the type of science described when making judgments about the value of the research. Contrary to popular claims, this suggests that scientific knowledge alone is no protection against the effects of bias on research evaluation. Implications for the practice and popularization of science are discussed.     

Characterization of aggressive behavior and phenytoin response

Recent work has suggested that the success of pharmacological treatment for chronic aggressive behavior may depend, in part, on the subtype of aggressive behavior displayed (e.g. reactive, impulsive aggression vs. predatory, premeditated aggression). The present study examined the usefulness of characterizing aggressive behavior during a 16‐week double‐blind crossover study of phenytoin (PHT) treatment in 41 aggressive adult males. The Impulsive/Premeditated Aggression Scales (IPAS) were used to characterize aggressive behavior as predominantly impulsive or predominantly premeditated in nature. Analyses indicated that participants who did not respond to PHT treatment endorsed significantly more premeditated characteristics on the IPAS than those who responded to PHT treatment. Non‐responders also exhibited fewer aggressive outbursts during placebo treatment, suggesting a greater level of behavior control. Participants who did not complete the study were younger, endorsed significantly more premeditated aggression characteristics and reported more lifetime antisocial behaviors than those who completed the study. Taken together, these data emphasize several factors that may influence the success of pharmacological treatment in aggressive individuals, namely the importance of characterizing the predominant type of problem aggressive behavior. Aggr. Behav. 00:1–6, 2005. © 2005 Wiley‐Liss, Inc.     

Individual Difference Correlates of the Experience of Sexual Harassment Among Female University Students1

Individuals often report experiences that conform to objective definitions of sexual harassment, but rarely report the subjective perception that they have been sexually harassed. The present research proposed that individual difference factors may mediate this commonly observed discrepancy. It was hypothesized that erotophobia, sexual inexperience, youth, sex role traditionality, repressing defensive style, and need for social approval have a weak inhibitory effect on reports of objectively defined experiences of sexual harassment, but a strong inhibitory effect on subjective perceptions that one has been sexually harassed. Results showed that individual difference factors including erotophobia, repressing defenses, and need for social approval were associated with fewer reported objective experiences of sexual harassment, while the base rate of subjective perception that one had been sexually harassed was very low, and this subjective perception was generally unassociated with individual difference factors. Discussion focuses on individual difference characteristics and motivation to ignore or to fail to report objective experiences of sexual harassment, and on suggestions for further research into the very high base rate of objectively defined experiences of sexual harassment and the very low base rate of perceived sexual harassment.     

HYPERCOMPARATIVES

In natural language we rarely use relation-words with more than three argument places. This paper studies one systematic device, rooted in natural language, by which relations of greater adicity can be expressed. It is based on a higher-order relation between 1-place, 2-place, and 4-place relations (and so on) of which the relation between the positive and comparative degrees of a predicate is a special case. Two formal languages are presented in this connection, one of which represents the language of communication and the other the contextual information against which the first language is interpreted. A semantical theory is described, which treats the two languages in an interdependent way. Logical consequence is non-compact. Connections with issues about vagueness are made.     

The unimportance of explicit spatial information in serial recall of visually presented lists

The superiority of auditory over visual presentation in short-term serial recall may be due to the fact that typically only temporal cues to order have been provided in the two modalities. Auditory information is usually ordered along a temporal continuum, whereas visual information is ordered spatially, as well. It is therefore possible that recall following visual presentation may benefit from spatial cues to order. Subjects were tested for serial recall of letter-sequences presented visually either with or without explicit spatial cues to order. No effect of any kind was found, a result which suggests (a) that spatial information is not utilized when it is redundant with temporal information and (b) that the auditory-visual difference would not be modified by the presence of explicit spatial cues to order.