论个体差异与诊疗决策

诊疗决策最优化的过程,本质上是针对特定的患者,制定最适合其个体差异的决策过程.对个体差异认知方式,经验医学基于对个体的不完全归纳,循证医学基于对群体随机、双盲、对照、大样本,人类基因组学基于对人类基因的差异表达、单核苷酸多态和复制变异的研究.最优化的治疗方案应体现关注患者心理、社会差异、关注生命质量、远离趋利性等人文特征;体现针对个体病患生物学特性差异、个体病程病期和个体最佳疗效差异等科学特征.     

Propofol induction reduces the capacity for neural information integration: Implications for the mechanism of consciousness and general anesthesia

The cognitive unbinding paradigm suggests that the synthesis of neural information is attenuated by general anesthesia. Here, we analyzed the functional organization of brain activities in the conscious and anesthetized states, based on functional segregation and integration. Electroencephalography (EEG) recordings were obtained from 14 subjects undergoing induction of general anesthesia with propofol. We quantified changes in mean information integration capacity in each band of the EEG. After induction with propofol, mean information integration capacity was reduced most prominently in the γ band of the EEG (p = .0001). Furthermore, we demonstrate that loss of consciousness is reflected by the breakdown of the spatiotemporal organization of γ waves. We conclude that induction of general anesthesia with propofol reduces the capacity for information integration in the brain. These data directly support the information integration theory of consciousness and the cognitive unbinding paradigm of general anesthesia.     

Anticipating intentional actions: The effect of eye gaze direction on the judgment of head rotation

Using a representational momentum paradigm, this study investigated the hypothesis that judgments of how far another agent’s head has rotated are influenced by the perceived gaze direction of the head. Participants observed a video-clip of a face rotating 60° towards them starting from the left or right profile view. The gaze direction of the face was either congruent with, ahead of, or lagging behind the angle of rotation. Following this, two static faces, at varying angles of rotation with respect to the end-point angle of the face in the video-clip, were presented simultaneously. The task of the participants was to decide which of the two heads was at an angle best resembling the angle of the end-point of the moving face. The critical test condition consisted of one test face oriented at 10° before, and the other at 10° after the end-point. The ‘lagging behind’ gaze condition elicited a significant underestimation of the rotation compared to the ‘congruent’ and ‘ahead’ gaze conditions. Participants did not exhibit similar biases when judging the rotation of several non-face control stimuli with visual features that mimicked different aspects of gaze direction. The findings suggest that when the gaze direction of a perceived agent is incongruent with the direction of the agent’s head motion observers automatically utilise this discrepancy to adjust their inferences about the agent’s intended heading direction.     

探讨人乳头瘤病毒L1蛋白功能及其临床意义

高危型别人乳头瘤病毒（HPV）感染在宫颈癌发生发展中具有重要作用。由于HPV L1蛋白结构特征及其精确的抗原特性,在粘附宿主细胞、识别病毒受体、协助病毒DNA的入胞转运中均发挥重要作用。检测患者宫颈损伤组织中L1蛋白的表达将有助于对患者是否具有传染性进行评估。本文将深刻思考HPV L1功能及其在感染机体并引发癌变的机制,以期更好的解读宫颈癌发病原理并最终应用于,强床治疗。     

大学生专业匹配性与学业成绩相关研究

采用自编大学生专业匹配性问卷对五个专业552名大学生进行调查,结果表明:(1)各个专业需要各自不同的学习方式.进入大学之后的学习都带有很强的专业性,因而各个专业都需要与专业特点相一致的独特的学习方式.(2)大学生的专业匹配性与学业成绩呈显著的正相关.本研究给高中生填报高考志愿提供了较为准确的心理学依据,能够促进在校大学生的学习,并为高校教学和管理提供可资借鉴的措施.     

我国高校对心理咨询与治疗人才的培养现状调查

本研究旨在调查我国高校对心理咨询与治疗人才的培养现状并分析其中存在的问题与需求.在我国华东、华西、华南、华北、华中地区选取22所不同类型,具有临床心理、咨询心理或应用心理学专业的本科、研究生培养计划的高等院校,搜集其课程设置、实践训练方面的资料,分析调查结果并与发达国家进行比较.结果发现存在一些问题,与发达国家相比尚存在着较大的差距.其中本科生的课程设置主要存在少数学校专业必修课和专业选修课的关系处理不合理、部分学校对心理咨询和治疗课程的培训不足,绝大多数学校无伦理课程培训等问题.研究生的课程体系较不完善,尤需加强对科学和道德伦理,行为的生物基础、行为的认知-情感基础、心理师的个人与专业发展、心理评估和诊断,心理咨询与治疗流派等领域的课程培训.本科生和研究生的实习训练方面,均存在实习内容不全面、实习时问短等问题.此外,本科人才的培养模式问题也值得深入研究探讨.     

Children's ascriptions of property rights with changes of ownership

Ownership is not a “natural” property of objects, but is determined by human intentions. Facts about who owns what may be altered by appropriate decisions. However, young children often deny the efficacy of transfer decisions, asserting that original owners retain rights to their property. In Experiment 1, 4–5-year-old and 7–8-year-old children and adults were asked to resolve disputes between initial owners and various types of receivers (finders, borrowers, buyers). Experiment 2 involved disputes both before and after transfers of ownership. At all ages participants privileged owners over non-owners and accepted the effectiveness of property transfers. Overall, children's intuitions about property rights were similar to those of adults. Observed differences may reflect older participants’ willingness to segregate property rights from other considerations in assessing the acceptability of actions.     

Chicks Injected with Antisera to either S-100α or S-100β Protein Develop Amnesia for a Passive Avoidance Task

The cellular expression of S-100β protein is upregulated in Alzheimer's disease and in Down's syndrome, and this protein has been implicated in memory-related processes in laboratory animals. However, the possibility that the α subunit of S-100 is also involved in memory has not yet been examined. In the present study, day-old black Australorp white Leghorn cockerel chicks (Gallus domesticus) received injections of monoclonal antisera to S-100α (1:50) or S-100β (1:500) into each hemisphere immediately after training on a one-trial passive avoidance task. The chicks displayed significantly lower retention levels than control birds that had been injected with antisera to carbonic anhydrase, or with saline (p< .01). S-100α antisera had an amnestic effect when injected between 0 and 20 min after training, with memory deficits occurring from 30 min postlearning, at the point of transition between the A and the B phases of the Gibbs-Ng intermediate memory stage. By contrast, the S-100β antisera needed to be injected either 5 min before or immediately after training and produced amnesia 10 min earlier, at the start of the A phase of the intermediate memory stage. We conclude that the two subunits of the S-100 protein are required at different points in the sequence of events leading to the consolidation of passive avoidance memory.     

Couple Psychoeducation for New Parents: Observed and Potential Effects on Parenting

The transition to parenthood is a substantial challenge for many couples, and the extent to which the partners can support each other and their relationship is strongly related to the sensitivity and responsiveness of their parenting of their infant. This paper critically analyses the links between the couple relationship and parenting of infants and reviews the research evaluating couple psychoeducation (CP) to assist couples’ parenting of their infant. It is concluded that CP has considerable potential to enhance couples’ adaptation to parenthood and enhance the sensitivity and responsiveness of parenting of new infants.