Increasing ethnic minority participation in substance abuse clinical trials: lessons learned in the National Institute on Drug Abuse's Clinical Trials Network

Underrepresentation in clinical trials limits the extent to which ethnic minorities benefit from advances in substance abuse treatment. The objective of this article is to share the knowledge gained within the Clinical Trials Network (CTN) of the National Institute on Drug Abuse and other research on recruiting and retaining ethnic minorities into substance abuse clinical trials. The article includes a discussion of two broad areas for improving inclusion-community involvement and cultural adaptation. CTN case studies are included to illustrate three promising strategies for improving ethnic minority inclusion: respondent-driven sampling, community-based participatory research, and the cultural adaptation of the recruitment and retention procedures. The article concludes with two sections describing a number of methodological concerns in the current research base and our proposed research agenda for improving ethnic minority inclusion that builds on the CTN experience.     

Acquisition of decision making criteria: reward rate ultimately beats accuracy

Speed-accuracy trade-offs strongly influence the rate of reward that can be earned in many decision-making tasks. Previous reports suggest that human participants often adopt suboptimal speed-accuracy trade-offs in single session, two-alternative forced-choice tasks. We investigated whether humans acquired optimal speed-accuracy trade-offs when extensively trained with multiple signal qualities. When performance was characterized in terms of decision time and accuracy, our participants eventually performed nearly optimally in the case of higher signal qualities. Rather than adopting decision criteria that were individually optimal for each signal quality, participants adopted a single threshold that was nearly optimal for most signal qualities. However, setting a single threshold for different coherence conditions resulted in only negligible decrements in the maximum possible reward rate. Finally, we tested two hypotheses regarding the possible sources of suboptimal performance: (1) favoring accuracy over reward rate and (2) misestimating the reward rate due to timing uncertainty. Our findings provide support for both hypotheses, but also for the hypothesis that participants can learn to approach optimality. We find specifically that an accuracy bias dominates early performance, but diminishes greatly with practice. The residual discrepancy between optimal and observed performance can be explained by an adaptive response to uncertainty in time estimation.     

Superego: an attachment perspective

With the help of attachment theory and research, the paper attempts to broaden and build on classical and current views on the superego. Attachment theory's epigenetic approach and the concept of the subliminal superego are described. The superego, it is argued, is as much concerned with safety as sex. The superego is 'heir', not just to the Oedipus complex or Klein's pre-oedipal constellation, but also to the attachment relationship. Under favourable developmental conditions a 'mature superego' emerges, facilitating, in the presence of an internal secure base, maturational boundary crossings towards adult sexuality. In the light of the above, the paper reviews Lear's updating of Strachey's model of psychic change and explores the concept of transgression in relation to the 'professional superego', its development and maturation. Theoretical arguments are illustrated with clinical examples.     

Managing motivational conflict: How self-esteem and executive resources influence self-regulatory responses to risk

This article explores how self-esteem and executive resources interact to determine responses to motivational conflict. One correlational and 3 experimental studies investigated the hypothesis that high and low self-esteem people undertake different self-regulatory strategies in "risky" situations that afford opportunity to pursue competing goals and that carrying out these strategies requires executive resources. When such resources are available, high self-esteem people respond to risk by prioritizing and pursuing approach goals, whereas low self-esteem people prioritize avoidance goals. However, self-esteem does not influence responses to risk when executive resources are impaired. In these studies, risk was operationalized by exposing participants to a relationship threat (Studies 1 and 2), by using participants' self-reported marital conflict (Study 3), and by threatening academic competence (Study 4). Executive resources were operationalized as cognitive load (Studies 1 and 2), working memory capacity (Study 3), and resource depletion (Study 4). When executive resources were ample, high self-esteem people responded to interpersonal risk by making more positive relationship evaluations (Studies 1, 2, and 3) and making more risky social comparisons following a personal failure (Study 4) than did low self-esteem people. Self-esteem did not predict participants' responses when executive resources were impaired or when risk was absent. The regulatory function of self-esteem may be more resource-dependent than has been previously theorized. (PsycINFO Database Record (c) 2012 APA, all rights reserved).     

Eye gaze metrics reflect a shared motor representation for action observation and movement imagery

Action observation (AO) and movement imagery (MI) have been reported to share similar neural networks. This study investigated the congruency between AO and MI using the eye gaze metrics, dwell time and fixation number. A simple reach-grasp-place arm movement was observed and, in a second condition, imagined where the movement was presented from the first person perspective (1PP) and the third person perspective (3PP). Dwell time and number of fixations were calculated for whole scene and regions of interest (ROIs). For whole scene, no significant differences were found in the number of fixations for condition (AO, MI) or perspective. Dwell time, however, was significantly longer in AO than MI. For ROIs, the number of fixations was significantly greater in 1PP than 3PP. The data provide support for congruence between motor simulation states but also indicate some functional differences.     

The Role of Beliefs in Mother-Adolescent Conflict: An Application of the Theory of Planned Behavior

This mixed method study applies components of the theory of planned behavior (Ajzen and Fishbein 1980) to mother-adolescent conflict. We examine if three kinds of beliefs—behavioral, control, and normative—predict patterns of family conflict. Forty mother-adolescent dyads completed an open-ended interview, self-report measures of conflict, and an observational measure of family interaction. Hierarchical multiple regressions revealed that mothers’ and adolescents’ beliefs about the costs and benefits of conflict significantly predicted how they interacted and perceived conflict within dyads. Sex differences and differences between mothers and adolescents were identified. This work contributes to our understanding of the role of both general and specific beliefs in family conflict.