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DS Jessop JA Douthwaite GL Conde SL Lightman CM Dayan MS Harbuz 《Stress (Amsterdam, Netherlands)》1997,2(2):133-144
Acute stress stimulates the expression and release of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) from the hypothalamus, and the pro-opiomelanocortin products beta-endorphin and ACTH from the anterior pituitary. These neuropeptides are also expressed in immune tissues, and it has been proposed that they may modulate immune responses to stress through paracrine mechanisms. We subjected rats to restraint stress or central injection of interleukin (IL)-1beta to determine whether these acute stimuli can alter the expression of neuropeptides in the spleen and thymus. Restraint stress significantly increased the contents of all these neuropeptides in thymic, but not splenic, extracts. A single icv injection of IL-1beta increased contents of CRH, AVP, ACTH and beta-endorphin in the spleens of both sham-operated and adrenalectomised (ADX) rats. IL-1beta increased thymic contents of CRH and ACTH in sham-operated rats but these increases were not observed in ADX rats. These results suggest that the effects of IL-1beta on neuropeptide expression in the spleen are independent of glucocorticoids, whereas IL-1beta stimulation of neuropeptide expression in the thymus is dependent on circulating glucocorticoids. There were significant correlations between increases in CRH, ACTH and beta-endorphin in the spleen, and between CRH and ACTH in the thymus, consistent with the suggestion that IL-1beta-induced increases in ACTH and beta-endorphin may be mediated through CRH. These results provide evidence that stressors can directly influence neuropeptide expression in immune tissues. Thus stress may influence immune functions through paracrine mechanisms involving locally synthesised neuropeptides as well as through activation of the hypothalamo-pituitary-adrenal axis. 相似文献
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Paul A. Holmes STD 《Journal of religion and health》1996,35(2):125-140
The treatment of intimacy failure in Roman Catholic priests in an outpatient program designed to treat sexual misconduct is
discussed here. Three case vignettes highlight a particular feature of an intimacy deficit that sets the stage for the priests'
sexual acting out. Intimacy, hypocrisy, and self-deception and the Catholic sacramental world view are discussed to shed light
on the treatment of sexual addiction in the clergy. Tapping into a priest's beliefs regarding the divine power arising from
his own ordination creates a nexus of healing where psychotherapy and spiritual direction join forces to produce a kind of
“sacramental psychology.”
This material was originally offered as part of a Grand Rounds presentation at St. Vincent's Hospital and Medical Center in
New York City. 相似文献
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Betty B. Hoskins Ph.D. Helen Bequaert Holmes Ph.D. 《The Journal of medical humanities》1985,6(1):28-37
Life situations often seem to require dualistic, either or decision making, but this common method does not always clarify moral decisions. To show this, standard arguments on why to choose or not to choose the sex or ones child are presented. Then, our feminist thinking, which regards clusters of values, and which reframes questions rather than choosing between desirable alternatives, suggests another possibility, in a gynandrous world vision. 相似文献
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Mary L. Jasnoski David S. Holmes Sheldon Solomon Chris Aguiar 《Journal of research in personality》1981,15(4):460-466
Subjects in an exercise training condition participated in a 10-week aerobic exercise class, whereas subjects in waiting-list control and independent control conditions did not. The results indicated that subjects in the training condition evidenced reliably greater improvements in physical fitness (aerobic capacity) and reported reliably greater improvements in their abilities and confidence in both the physical area (e.g., ability to run distances) and nonphysical area (e.g., frustration tolerance) than did subjects in the control conditions. On the other hand, improvements in physical fitness were not related to reported improvements in abilities and confidence. These findings are of interest because they indicate that some of the important personal changes that are associated with physical fitness training are not due to changes in fitness, but appear to be due to other factors (e.g., group participation and expectancies). 相似文献
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835 community college students were surveyed to establish the prevalence of head injury or illness. Results are compared to prevalence rates among 4-year college students. 相似文献
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The current paper represents an attempt to clarify the nature of the radical behaviorist’s perspective on human cognition. This attempt will involve an examination of recent behavioral research into the relationship between stimulus equivalence phenomena and symbolic behavior, and language more generally. This form of behavior analysis is offered as an alternative to, but not a replacement for, other methodological and conceptual approaches to psychology.
相似文献19.
The perceptual complexity of lexically ambiguous and unambiguous sentences was compared in three experiments. In Experiment 1, the report of ambiguous words from rapidly presented ambiguous sentences was worse than the report of corresponding unambiguous words from unambiguous sentences. Results of Experiment 2 showed that the effect was not reduced by the presence of prior biasing context within the sentence. Experiment 3 repeated the finding with a sentence meaning classification task. It was concluded that both meanings of a lexically ambiguous sentence must be computed, even when prior context makes one meaning more plausible than the other. 相似文献
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