Timing of Conditioned Responses Utilizing Electrical Stimulation in the Region of the Interpositus Nucleus as a CS

A large body of evidence indicates that the cerebellum is essential for the acquisition, retention, and expression of the standard delay conditioned eyeblink response and that the basic memory trace appears to be established in the anterior interpositus nucleus (IP). Adaptive timing of the conditioned response (CR) is a prominent feature of classical conditioning-the CR peaks at the time of onset of the unconditioned stimulus (US) over a wide range of CS-US interstimulus intervals (ISI). A key issue is whether this timing is established by the cerebellar circuitry or prior to the cerebellum. In this study timing of conditioned eyeblink responses established via electrical stimulation of the interpositus nucleus as a conditioned stimulus (CS) was analyzed prior to and following modification of the CS-US interval in well-trained rabbits. Consistent with previous results, learning under these conditions is very rapid and robust. The CR peak eyeblink latencies are initially timed to the US onset and adjust accordingly to lengthening or shortening of the CS-US interval, just as with peripheral CSs. The acquisition of conditioned eyeblink responses by direct electrical stimulation of the IP as a CS thus retains temporal flexibility following shifts in the CS-US delay, as found in standard classical eyeblink conditioning procedures.     

Verb deficits in Alzheimer's disease and agrammatism: implications for lexical organization

This study examined the nature of verb deficits in 14 individuals with probable Alzheimer's Disease (PrAD) and nine with agrammatic aphasia. Production was tested, controlling both semantic and syntactic features of verbs, using noun and verb naming, sentence completion, and narrative tasks. Noun and verb comprehension and a grammaticality judgment task also were administered. Results showed that while both PrAD and agrammatic subjects showed impaired verb naming, the syntactic features of verbs (i.e., argument structure) influenced agrammatic, but not Alzheimer's disease patients' verb production ability. That is, agrammatic patients showed progressively greater difficulty with verbs associated with more arguments, as has been shown in previous studies (e.g., Kim & Thompson, 2000; Thompson, 2003; Thompson, Lange, Schneider, & Shapiro, 1997), and suggest a syntactic basis for verb production deficits in agrammatism. Conversely, the semantic complexity of verbs affected PrAD, but not agrammatic, patients' performance, suggesting "bottom-up" breakdown in their verb lexicon, paralleling that of nouns, resulting from the degradation or loss of semantic features of verbs.     

CBT intensity and outcome for panic disorder in a primary care setting

A hybrid efficacy-effectiveness design in which participants (n = 91/93) were retained in the study regardless of whether or not they received treatment enabled evaluation of CBT intensity in relation to panic disorder in the primary care setting. CBT intensity was operationalized as number of cognitive-behavioral therapy sessions, number of follow-up booster phone calls, and secondarily, as number of cognitive behavioral coping and exposure strategies. Baseline psychosocial and demographic predictors of CBT intensity were analyzed first. Severity of anxiety sensitivity predicted number of cognitive behavioral sessions, but no baseline variables predicted number of follow-up booster phone calls or number of coping and exposure strategies. Multivariate logistic and linear regressions were used to evaluate the degree to which treatment intensity predicted 3-month and 12-month outcomes (anxiety sensitivity, phobic avoidance, depressive symptoms, disability, and medical and mental health functioning) after controlling for potential confounding baseline variables. Number of cognitive behavioral therapy sessions predicted lower anxiety sensitivity at 3 and 12 months, and number of follow-up booster phone calls predicted lower anxiety sensitivity, less phobic avoidance, and less depression at 12 months. These findings indicate that "dose" of psychotherapy was an important predictor of outcome. The significance of follow-up booster phone contact is discussed as an index of continued self-management of panic and anxiety following acute treatment.     

Autonomy and Nondefensiveness

Three experimental studies tested whether a priming procedure intended to activate an autonomy orientation would lead to nondefensiveness and enhanced performance, whether activated control orientation would lead to higher defense and impaired performance, and whether activated impersonal orientation would lead to the greatest defense and worst performance. Study 1 showed that autonomy-primed participants report lower desire for escape compared to control-primed, and that impersonally-primed showed most desire to escape. In Study 2, autonomy-primed participants showed the least self-serving bias, control-primed were in the middle, and impersonally-primed participants showed the most. In Study 3, rowers autonomy-primed showed the least self-handicapping and best performance, control-primed showed moderate levels, and impersonally-primed showed the most self-handicapping and worst performance. Results are discussed in terms of motivation orientation, defensiveness, and performance.

A sufficient condition for conditional expectation to be monotonically related to distribution parameters

In this paper we give a sufficient condition for conditional expectation to be a monotonic function of a parameter of the joint probability distribution. A second sufficient condition is given for the case where varying the parameter of the joint distribution leaves the shape of that distribution unchanged. Finally, an application of the condition is illustrated on the counter models for choice reaction time of LaBerge (1962) and Nickerson (1969).     

Sex-role identity and male and female homosexuality

The incidences of sex-role outcome within homosexual and heterosexual male and female young adult samples were compared using a fourfold typology (both masculine and feminine, masculine, feminine, neither masculine nor feminine). Sex-role identity disparities between the female groups were more clear-cut; the most striking difference was the high incidence of masculinity (60%) within the homosexual female group. No significant differences for males were found, although a trend was noted toward higher incidence of femininity and lower incidence of masculinity in homosexuals. The second purpose of the study was to search for possible developmental antecedents to heterosexual deficit in unselected college samples. The same key pattern of psychometric indices was identified for males and females. Low heterosexuality and the closest approximation to the modal sex-role identity among homosexuals of their sex were found in females primarily identified with masculine fathers and low in role consistency and in males primarily identified with feminine mothers and low in role consistency.     

Depth of processing: When the principle of congruity fails

Two factors, level of processing (Craik & Lockhart, 1972) and congruity (Schulman, 1974), known to have large effects on the recall of experimenter-provided responses to questions, were examined in a series of five incidental learning experiments using subject-generated responses. The data show that manipulation of level of processing has the same effect on recall of subjectgenerated responses as it does on experimenter-provided responses. However, the effect of congruity is reversed for subject-generated responses. The data suggest that the difficulty of generating unrelated responses (“incongruous“ items) may account, at least in part, for the failure of the “principle of congruity“ with subject-generated responses.